PDB entry 6up9

View 6up9 on RCSB PDB site
Description: crystal structure of t467a variant of cytosolic fumarate hydratase from leishmania major in a complex with malonate
Deposited on 2019-10-16, released 2019-12-04
The last revision was dated 2019-12-18, with a file datestamp of 2019-12-13.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: fumarate hydratase 2
    Species: Leishmania major strain Friedlin [TaxId:347515]
    Gene: FH2, LMJF_29_1960
    Database cross-references and differences (RAF-indexed):
    • Uniprot E9AE57 (Start-603)
      • engineered mutation (502)
  • Chain 'B':
    Compound: fumarate hydratase 2
    Species: Leishmania major strain Friedlin [TaxId:347515]
    Gene: FH2, LMJF_29_1960
    Database cross-references and differences (RAF-indexed):
    • Uniprot E9AE57 (Start-603)
      • engineered mutation (502)
  • Heterogens: MLA, SF4, GOL, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6up9A (A:)
mgsshhhhhhssglvprgshmasmtggqqmgrgsefmslcdqceigcrrvgikdiedasa
vnadfhfsaifqptdphhhqtefakvegsekyveevevfgrqalkvnpealtilahrafs
dvhhffrkdhlegwrraiedpeasdndryvattllknaciaagrvlpscqdtgtaivlgk
rgelcwtggedekylskgiwnayryhnlrysqtaaldmfkecntgdnlpaqldllavpgs
dyeflfiakgggsankaylyqetkallnpkslrafieeklktlgtaacppyhialviggt
saemtmktvklascryydslpttgdkygrafrdpewekivmevaqksgigaqfggkyfah
qarvirlprhgascpvglavscsadrqilahinksgiyieqleqnpaqylpdipevhlst
tsvkvdlkrpidkvrqqlsqypvgtrvmlngtlivardiahakikemmdngeplpeymkt
spiyyagpaktpegyasgsfgpatagrmdsyvdlfqshggsyitlakgnrskqvtdackk
hggfylgsiggpaailakdsikqvtclafpelgmeavwkievedfpafivvddkgndmys
ktla

    Sequence, based on observed residues (ATOM records):
    >6up9A (A:)
dfhfsaifqptdphhhqtefakvegsekyveevevfgrqalkvnpealtilahrafsdvh
hffrkdhlegwrraiedpeasdndryvattllknaciaagrvlpscqdtgtaivlgkrge
lcwtggedekylskgiwnayryhnlrysqtaaldmfkecntgdnlpaqldllavpgsdye
flfiakgggsankaylyqetkallnpkslrafieeklktlgtaacppyhialviggtsae
mtmktvklascryydslpttgdkygrafrdpewekivmevaqksgigaqfggkyfahqar
virlprhgascpvglavscsadrqilahinksgiyieqleqnpaqylptsvkvdlkrpid
kvrqqlsqypvgtrvmlngtlivardiahakikemmdngeplpeymktspiyyagpaktp
egyasgsfgpatagrmdsyvdlfqshggsyitlakgnrskqvtdackkhggfylgsiggp
aailakdsikqvtclafpelgmeavwkievedfpafivvddkgndmysktla

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6up9B (B:)
mgsshhhhhhssglvprgshmasmtggqqmgrgsefmslcdqceigcrrvgikdiedasa
vnadfhfsaifqptdphhhqtefakvegsekyveevevfgrqalkvnpealtilahrafs
dvhhffrkdhlegwrraiedpeasdndryvattllknaciaagrvlpscqdtgtaivlgk
rgelcwtggedekylskgiwnayryhnlrysqtaaldmfkecntgdnlpaqldllavpgs
dyeflfiakgggsankaylyqetkallnpkslrafieeklktlgtaacppyhialviggt
saemtmktvklascryydslpttgdkygrafrdpewekivmevaqksgigaqfggkyfah
qarvirlprhgascpvglavscsadrqilahinksgiyieqleqnpaqylpdipevhlst
tsvkvdlkrpidkvrqqlsqypvgtrvmlngtlivardiahakikemmdngeplpeymkt
spiyyagpaktpegyasgsfgpatagrmdsyvdlfqshggsyitlakgnrskqvtdackk
hggfylgsiggpaailakdsikqvtclafpelgmeavwkievedfpafivvddkgndmys
ktla

    Sequence, based on observed residues (ATOM records):
    >6up9B (B:)
dfhfsaifqptdphhhqtefakvegsekyveevevfgrqalkvnpealtilahrafsdvh
hffrkdhlegwrraiedpeasdndryvattllknaciaagrvlpscqdtgtaivlgkrge
lcwtggedekylskgiwnayryhnlrysqtaaldmfkecntgdnlpaqldllavpgsdye
flfiakgggsankaylyqetkallnpkslrafieeklktlgtaacppyhialviggtsae
mtmktvklascryydslpttgdkygrafrdpewekivmevaqksgigaqfggkyfahqar
virlprhgascpvglavscsadrqilahinksgiyieqleqnpaqylptsvkvdlkrpid
kvrqqlsqypvgtrvmlngtlivardiahakikemmdngeplpeymktspiyyagpaktp
egyasgsfgpatagrmdsyvdlfqshggsyitlakgnrskqvtdackkhggfylgsiggp
aailakdsikqvtclafpelgmeavwkievedfpafivvddkgndmysktla