PDB entry 6uon

View 6uon on RCSB PDB site
Description: molecular basis for tumor infiltrating tcr recognition of hotspot kras-g12d mutation
Deposited on 2019-10-15, released 2020-05-27
The last revision was dated 2020-06-17, with a file datestamp of 2020-06-12.
Experiment type: XRAY
Resolution: 3.5 Å
R-factor: N/A
AEROSPACI score: 0.08 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: HLA class I antigen
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-Cw, HLA-C
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: gly-ala-asp-gly-val-gly-lys-ser-ala-leu
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01111 (0-9)
      • conflict (2)
  • Chain 'D':
    Compound: HLA class I antigen
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-Cw, HLA-C
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: gly-ala-asp-gly-val-gly-lys-ser-ala-leu
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01111 (0-9)
      • conflict (2)
  • Chain 'G':
    Compound: TCR-V-alpha-12-02*01
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6UON
  • Chain 'H':
    Compound: TCR-V-beta-10-2*01
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6UON
  • Chain 'I':
    Compound: TCR-V-alpha-12-02*01
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6UON
  • Chain 'J':
    Compound: TCR-V-beta-10-2*01
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6UON

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6uonA (A:)
cshsmryfytavsrpgrgeprfiavgyvddtqfvqfdsdaasprgeprapwveqegpeyw
dretqkykrqaqtdrvslrnlrgyynqseagshtlqrmygcdlgpdgrllrgynqfaydg
kdyialnedlrswtaadkaaqitqrkweaareaeqrraylegtcvewlrrylengkktlq
raehpkthvthhpvsdheatlrcwalgfypaeitltwqrdgedqtqdtelvetrpagdgt
fqkwaavvvpsgeeqrytchvqheglpepltlrw

    Sequence, based on observed residues (ATOM records):
    >6uonA (A:)
shsmryfytavsrpgrgeprfiavgyvddtqfvqfdsdaasprgeprapwveqegpeywd
retqkykrqaqtdrvslrnlrgyynqseagshtlqrmygcdlgpdgrllrgynqfaydgk
dyialnedlrswtaadkaaqitqrkweaareaeqrraylegtcvewlrrylengkktlqr
aehpkthvthhpvsdheatlrcwalgfypaeitltwqrdgedqtqdtelvetrpagdgtf
qkwaavvvpsgeeqrytchvqheglpepltlrw

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6uonB (B:)
iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

    Sequence, based on observed residues (ATOM records):
    >6uonB (B:)
iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrd

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records:
    >6uonC (C:)
gadgvgksal

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6uonD (D:)
cshsmryfytavsrpgrgeprfiavgyvddtqfvqfdsdaasprgeprapwveqegpeyw
dretqkykrqaqtdrvslrnlrgyynqseagshtlqrmygcdlgpdgrllrgynqfaydg
kdyialnedlrswtaadkaaqitqrkweaareaeqrraylegtcvewlrrylengkktlq
raehpkthvthhpvsdheatlrcwalgfypaeitltwqrdgedqtqdtelvetrpagdgt
fqkwaavvvpsgeeqrytchvqheglpepltlrw

    Sequence, based on observed residues (ATOM records):
    >6uonD (D:)
shsmryfytavsrpgrgeprfiavgyvddtqfvqfdsdaasprgeprapwveqegpeywd
retqkykrqaqtdrvslrnlrgyynqseagshtlqrmygcdlgpdgrllrgynqfaydgk
dyialnedlrswtaadkaaqitqrkweaareaeqrraylegtcvewlrrylengkktlqr
aehpkthvthhpvsdheatlrcwalgfypaeitltwqrdgedqtqdtelvetrpagdgtf
qkwaavvvpsgeeqrytchvqheglpepltlrw

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6uonE (E:)
iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

    Sequence, based on observed residues (ATOM records):
    >6uonE (E:)
qrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdws
fyllyyteftptekdeyacrvnhvtlsqpkivkwdrd

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records:
    >6uonF (F:)
gadgvgksal

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6uonG (G:)
mkeveqnsgplsvpegaiaslnctysdrgsqsffwyrqysgkspelimfiysngdkedgr
ftaqlnkasqyvsllirdsqpsdsatylcaaamdssyklifgsgtrllvrpdiqnpdpav
yqlrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnks
dfacanafnnsiipedtffpsp

    Sequence, based on observed residues (ATOM records):
    >6uonG (G:)
eveqnsgplsvpegaiaslnctysdrgsqsffwyrqysgkspelimfiysngdkedgrft
aqlnkasqyvsllirdsqpsdsatylcaaamdssyklifgsgtrllvrpdiqnpdpavyq
lrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnksdf
acanafnnsiipedtffps

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6uonH (H:)
magitqsprykitetgrqvtlmchqtwshsymfwyrqdlghglrliyysaaaditdkgev
pdgyvvsrsktenfpltlesatrsqtsvyfcassdpgteaffgqgtrltvvedlrnvfpp
evavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeqpal
ndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeawgra
d

    Sequence, based on observed residues (ATOM records):
    >6uonH (H:)
gitqsprykitetgrqvtlmchqtwshsymfwyrqdlghglrliyysaaaditdkgevpd
gyvvsrsktenfpltlesatrsqtsvyfcassdpgteaffgqgtrltvvedlrnvfppev
avfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeqpalnd
sryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeawgra

  • Chain 'I':
    Sequence, based on SEQRES records:
    >6uonI (I:)
mkeveqnsgplsvpegaiaslnctysdrgsqsffwyrqysgkspelimfiysngdkedgr
ftaqlnkasqyvsllirdsqpsdsatylcaaamdssyklifgsgtrllvrpdiqnpdpav
yqlrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnks
dfacanafnnsiipedtffpsp

    Sequence, based on observed residues (ATOM records):
    >6uonI (I:)
veqnsgplsvpegaiaslnctysdrgsqsffwyrqysgkspelimfiysngdkedgrfta
qlnkasqyvsllirdsqpsdsatylcaaamdssyklifgsgtrllvrpdiqnpdpavyql
rdsksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnksdfacana
fnnsiipedtffp

  • Chain 'J':
    Sequence, based on SEQRES records:
    >6uonJ (J:)
magitqsprykitetgrqvtlmchqtwshsymfwyrqdlghglrliyysaaaditdkgev
pdgyvvsrsktenfpltlesatrsqtsvyfcassdpgteaffgqgtrltvvedlrnvfpp
evavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeqpal
ndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeawgra
d

    Sequence, based on observed residues (ATOM records):
    >6uonJ (J:)
gitqsprykitetgrqvtlmchqtwshsymfwyrqdlghglrliyysaaaditdkgevpd
gyvvsrsktenfpltlesatrsqtsvyfcassdpgteaffgqgtrltvvedlrnvfppev
avfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeqpalnd
sryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeawgra