PDB entry 6uob

View 6uob on RCSB PDB site
Description: Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 1 (CD1) K330L mutant complexed with Resminostat
Class: Hydrolase/Hydrolase Inhibitor
Keywords: Histone Deacetylase, Hydrolase-Hydrolase Inhibitor complex
Deposited on 2019-10-14, released 2019-12-04
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-12-04, with a file datestamp of 2019-11-29.
Experiment type: XRAY
Resolution: 1.58 Å
R-factor: N/A
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histone deacetylase 6
    Species: Danio rerio [TaxId:7955]
    Gene: HDAC6
    Database cross-references and differences (RAF-indexed):
    • Uniprot F8W4B7 (6-End)
      • engineered mutation (276)
    Domains in SCOPe 2.07: d6uoba_
  • Chain 'B':
    Compound: Histone deacetylase 6
    Species: Danio rerio [TaxId:7955]
    Gene: HDAC6
    Database cross-references and differences (RAF-indexed):
    • Uniprot F8W4B7 (6-End)
      • engineered mutation (276)
    Domains in SCOPe 2.07: d6uobb_
  • Heterogens: P7D, PHE, ZN, K, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6uobA (A:)
snaggsatgtglvyvdaftrfhclwdashpecparvstvmemletegllgrcvqvearav
tedelllvhtkeyvelmkstqnmteeelktlaekydsvylhpgffssaclsvgsvlqlvd
kvmtsqlrngfsinrppghhaqadkmngfcmfnnlaiaaryaqkrhrvqrvlivdwdvhh
gqgiqyifeedpsvlyfsvhryedgsfwphlkesdsssvgsgagqgyninlpwnkvgmes
gdyitafqqlllpvayefqpqlvlvaagfdavigdplggmqvspecfsilthmlkgvaqg
rlvlaleggynlqstaegvcasmrsllgdpcphlpssgapcesalksisktisdlypfwk
slqtfe

    Sequence, based on observed residues (ATOM records): (download) 
    >6uobA (A:)
atgtglvyvdaftrfhclwdashpecparvstvmemletegllgrcvqvearavtedell
lvhtkeyvelmkstqnmteeelktlaekydsvylhpgffssaclsvgsvlqlvdkvmtsq
lrngfsinrppghhaqadkmngfcmfnnlaiaaryaqkrhrvqrvlivdwdvhhgqgiqy
ifeedpsvlyfsvhryedgsfwphlkesdsssvgsgagqgyninlpwnkvgmesgdyita
fqqlllpvayefqpqlvlvaagfdavigdplggmqvspecfsilthmlkgvaqgrlvlal
eggynlqstaegvcasmrsllgdpcphlpssgapcesalksisktisdlypfwkslqt

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6uobB (B:)
snaggsatgtglvyvdaftrfhclwdashpecparvstvmemletegllgrcvqvearav
tedelllvhtkeyvelmkstqnmteeelktlaekydsvylhpgffssaclsvgsvlqlvd
kvmtsqlrngfsinrppghhaqadkmngfcmfnnlaiaaryaqkrhrvqrvlivdwdvhh
gqgiqyifeedpsvlyfsvhryedgsfwphlkesdsssvgsgagqgyninlpwnkvgmes
gdyitafqqlllpvayefqpqlvlvaagfdavigdplggmqvspecfsilthmlkgvaqg
rlvlaleggynlqstaegvcasmrsllgdpcphlpssgapcesalksisktisdlypfwk
slqtfe

    Sequence, based on observed residues (ATOM records): (download) 
    >6uobB (B:)
atgtglvyvdaftrfhclwdashpecparvstvmemletegllgrcvqvearavtedell
lvhtkeyvelmkstqnmteeelktlaekydsvylhpgffssaclsvgsvlqlvdkvmtsq
lrngfsinrppghhaqadkmngfcmfnnlaiaaryaqkrhrvqrvlivdwdvhhgqgiqy
ifeedpsvlyfsvhryedgsfwphlkesdsssvgsgagqgyninlpwnkvgmesgdyita
fqqlllpvayefqpqlvlvaagfdavigdplggmqvspecfsilthmlkgvaqgrlvlal
eggynlqstaegvcasmrsllgdpcphlpssgapcesalksisktisdlypfwkslq