PDB entry 6uo6

View 6uo6 on RCSB PDB site
Description: Crystal Structure of the R422Q missense variant of human PGM1
Class: isomerase
Keywords: isomerase, enzyme, missense variant
Deposited on 2019-10-14, released 2020-03-04
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-03-04, with a file datestamp of 2020-02-28.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Phosphoglucomutase-1
    Species: Homo sapiens [TaxId:9606]
    Gene: PGM1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P36871 (23-584)
      • expression tag (21-22)
      • engineered mutation (444)
    Domains in SCOPe 2.07: d6uo6a1, d6uo6a2, d6uo6a3, d6uo6a4, d6uo6a5
  • Chain 'B':
    Compound: Phosphoglucomutase-1
    Species: Homo sapiens [TaxId:9606]
    Gene: PGM1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P36871 (23-584)
      • expression tag (21-22)
      • engineered mutation (444)
    Domains in SCOPe 2.07: d6uo6b1, d6uo6b2, d6uo6b3, d6uo6b4, d6uo6b5
  • Heterogens: MG, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6uo6A (A:)
mhhhhhhssgvdlgtenlyfqsnmvkivtvktqayqdqkpgtsglrkrvkvfqssanyae
nfiqsiistvepaqrqeatlvvggdgrfymkeaiqliariaaangigrlvigqngilstp
avsciirkikaiggiiltashnpggpngdfgikfnisnggpapeaitdkifqisktieey
avcpdlkvdlgvlgkqqfdlenkfkpftveivdsveayatmlrsifdfsalkellsgpnr
lkiridamhgvvgpyvkkilceelgapansavncvpledfgghhpdpnltyaadlvetmk
sgehdfgaafdgdgdrnmilgkhgffvnpsdsvaviaanifsipyfqqtgvrgfarsmpt
sgaldrvasatkialyetptgwkffgnlmdasklslcgeesfgtgsdhirekdglwavla
wlsilatrkqsvedilkdhwqkygqnfftrydyeeveaegankmmkdlealmfdrsfvgk
qfsandkvytvekadnfeysdpvdgsisrnqglrliftdgsrivfrlsgtgsagatirly
idsyekdvakinqdpqvmlaplisialkvsqlqertgrtaptvit

    Sequence, based on observed residues (ATOM records): (download) 
    >6uo6A (A:)
snmvkivtvktqayqdqkpgtsglrkrvkvfqssanyaenfiqsiistvepaqrqeatlv
vggdgrfymkeaiqliariaaangigrlvigqngilstpavsciirkikaiggiiltash
npggpngdfgikfnisnggpapeaitdkifqisktieeyavcpdlkvdlgvlgkqqfdle
nkfkpftveivdsveayatmlrsifdfsalkellsgpnrlkiridamhgvvgpyvkkilc
eelgapansavncvpledfgghhpdpnltyaadlvetmksgehdfgaafdgdgdrnmilg
khgffvnpsdsvaviaanifsipyfqqtgvrgfarsmptsgaldrvasatkialyetptg
wkffgnlmdasklslcgeesfgtgsdhirekdglwavlawlsilatrkqsvedilkdhwq
kygqnfftrydyeeveaegankmmkdlealmfdrsfvgkqfsandkvytvekadnfeysd
pvdgsisrnqglrliftdgsrivfrlsagatirlyidsyekdvakinqdpqvmlaplisi
alkvsqlqertgrtaptvit

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6uo6B (B:)
mhhhhhhssgvdlgtenlyfqsnmvkivtvktqayqdqkpgtsglrkrvkvfqssanyae
nfiqsiistvepaqrqeatlvvggdgrfymkeaiqliariaaangigrlvigqngilstp
avsciirkikaiggiiltashnpggpngdfgikfnisnggpapeaitdkifqisktieey
avcpdlkvdlgvlgkqqfdlenkfkpftveivdsveayatmlrsifdfsalkellsgpnr
lkiridamhgvvgpyvkkilceelgapansavncvpledfgghhpdpnltyaadlvetmk
sgehdfgaafdgdgdrnmilgkhgffvnpsdsvaviaanifsipyfqqtgvrgfarsmpt
sgaldrvasatkialyetptgwkffgnlmdasklslcgeesfgtgsdhirekdglwavla
wlsilatrkqsvedilkdhwqkygqnfftrydyeeveaegankmmkdlealmfdrsfvgk
qfsandkvytvekadnfeysdpvdgsisrnqglrliftdgsrivfrlsgtgsagatirly
idsyekdvakinqdpqvmlaplisialkvsqlqertgrtaptvit

    Sequence, based on observed residues (ATOM records): (download) 
    >6uo6B (B:)
snmvkivtvktqayqdqkpgtsglrkrvkvfqssanyaenfiqsiistvepaqrqeatlv
vggdgrfymkeaiqliariaaangigrlvigqngilstpavsciirkikaiggiiltash
npggpngdfgikfnisnggpapeaitdkifqisktieeyavcpdlkvdlgvlgkqqfdle
nkfkpftveivdsveayatmlrsifdfsalkellsgpnrlkiridamhgvvgpyvkkilc
eelgapansavncvpledfgghhpdpnltyaadlvetmksgehdfgaafdgdgdrnmilg
khgffvnpsdsvaviaanifsipyfqqtgvrgfarsmptsgaldrvasatkialyetptg
wkffgnlmdasklslcgeesfgtgsdhirekdglwavlawlsilatrkqsvedilkdhwq
kygqnfftrydyeeveaegankmmkdlealmfdrsfvgkqfsandkvytvekadnfeysd
pvdgsisrnqglrliftdgsrivfrlsgatirlyidsyekdvakinqdpqvmlaplisia
lkvsqlqertgrtaptvit