PDB entry 6umx

View 6umx on RCSB PDB site
Description: Structural basis for specific inhibition of extracellular activation of pro/latent myostatin by SRK-015
Class: signaling protein/immune system
Keywords: Myostatin, GDF8, transforming growth factor beta, muscle wasting disease, antibody, fab, SIGNALING PROTEIN-IMMUNE SYSTEM complex
Deposited on 2019-10-10, released 2020-02-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-04-29, with a file datestamp of 2020-04-24.
Experiment type: XRAY
Resolution: 2.79 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Growth/differentiation factor 8
    Species: Homo sapiens [TaxId:9606]
    Gene: Mstn, Gdf8
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Growth/differentiation factor 8
    Species: Homo sapiens [TaxId:9606]
    Gene: Mstn, Gdf8
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: GL29H4-16 Fab Heavy Chain,GL29H4-16 Fab Heavy Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6UMX (Start-120)
    • Uniprot Q5EFE5 (121-End)
    Domains in SCOPe 2.08: d6umxh_
  • Chain 'L':
    Compound: GL29H4-16 Fab Light Chain,GL29H4-16 Fab Light Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6UMX (0-109)
    • Uniprot P0DOY2 (110-End)
    Domains in SCOPe 2.08: d6umxl1, d6umxl2
  • Chain 'h':
    Compound: GL29H4-16 Fab Heavy Chain,GL29H4-16 Fab Heavy Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6UMX (Start-120)
    • Uniprot Q5EFE5 (121-End)
  • Chain 'l':
    Compound: GL29H4-16 Fab Light Chain,GL29H4-16 Fab Light Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6UMX (Start-109)
    • Uniprot P0DOY2 (110-End)
  • Heterogens: GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    No sequence available.

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6umxH (H:)
qiqlvqsgggvvqpgrslrlscaasgftfssygmhwvrqapgkglewvavisydgsrkyy
adsvkgrftisrdnskntlylqmnslraedtavyycardllvrflywshyygmdvwgqgt
tvtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfp
avlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc

    Sequence, based on observed residues (ATOM records): (download) 
    >6umxH (H:)
iqlvqsgggvvqpgrslrlscaasgftfssygmhwvrqapgkglewvavisydgsrkyya
dsvkgrftisrdnskntlylqmnslraedtavyycardllvrflywshyygmdvwgqgtt
vtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpa
vlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >6umxL (L:)
qpvltqppsasgtpgqrvtiscsgsssnigsnpvhwyqqlpgtapklliyddnqrpsgvp
drfsgsksgtsaslvisglqsddeadyycaawddslnsvfgggtkltvlgqpkaapsvtl
fppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassy
lsltpeqwkshrsyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records): (download) 
    >6umxL (L:)
qpvltqppsasgtpgqrvtiscsgsssnigsnpvhwyqqlpgtapklliyddnqrpsgvp
drfsgsksgtsaslvisglqsddeadyycaawddslnsvfgggtkltvlgqpkaapsvtl
fppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassy
lsltpeqwkshrsyscqvthegstvektvaptec

  • Chain 'h':
    No sequence available.

  • Chain 'l':
    No sequence available.