PDB entry 6um2

View 6um2 on RCSB PDB site
Description: structure of m-6-p/igfii receptor and igfii complex
Deposited on 2019-10-08, released 2020-02-26
The last revision was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: EM
Resolution: 4.32 Å
R-factor: N/A
AEROSPACI score: 0.04 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cation-independent mannose-6-phosphate receptor
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: insulin-like growth factor II
    Species: Homo sapiens [TaxId:9606]
    Gene: IGF2, PP1446
    Database cross-references and differences (RAF-indexed):
  • Heterogens: NAG

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6um2A (A:)
meaaagrsshlgpapagrpprcplllqlqllllllllppgwvpgaagtqgaefpelcsyt
weavdtknnmlykinicgnmgvaqcgpssavcmhdlktdsfhsvgdsllktasrsllefn
ttvnckqqnhkiqssitflcgktlgtpefvtatdcvhyfewrttaackknifkankevpc
yafdrelkkhdlnpliktsgaylvddsdpdtslfinvcrdievlrasspqvrvcptgaaa
clvrgdrafdvgrpqeglklvsndrlvlsyvkegagqpdfcdghspavtitfvcpserre
gtipkltaksncrfeiewvteyachrdylesrscslssaqhdvavdlqplsrveasdslf
ytseadeytyylsicggsqapicnkkdaavcqvkkadstqvkvagrpqnltlrysdgdlt
liyfggeecssgfqrmsvinfecnqtagnngrgapvftgevdctyfftwdtkyacvheke
allcgvsdgkqrfdlsalarhseleqnweavdgsqreaekkhffinichrvlqtgqargc
pedaavcavdkngsknlgrfissptrekgniqlsysdgdecgggqkiitnitlmckpgdl
esapvlttsradgcfyefewrtaaacvlsrtegdnctvfdsqagfsfdltpltkkdaykv
etdkyefhinvcgpvsvgacppdsgacqvsrsdrkswnlgrsnaklsyydgmiqltyrdg
tpynnekrtpratlitflcdrdagvgfpeyqeednstynfrwytsyacpeeplecivtdp
vtldqydlsrlakseggpggnwysldnggarstwrkyyinvcrplnpvpgcdryasacqm
kyqgeqgsysetvsisnlgvaktgpmvedsgsllleyvngsacttsdqrrttyttrihlv
cstgslythpifslnwecvvsflwntaaacpirittdidqvcsikdpnsgyvfdlnplnn
srgyvvlgigktflfnvcgdmpacgtldgkpasgceaevqmddmktlkpgrlvglekslq
lstegfitlnytglpshpngradafiirfvcnddvypgtpkflhqdidsslgirdtffef
etalacvpspvdcqvtdpagneydlsglskarkpwtavdtfdegkkrtfylsvctplpyi
pgchgtavgcclvtedsklnlgvvqispqvgangslslvyvngdkcknqrfstrinleca
httgsptfqlqndceyvflwrtveacpvvraegdycevrdprhgnlynliplglndtvvr
ageytyyfrvcgeltsgvcptsdkskvisscqekrgpqgfqkvaglfnqkltyengvlkm
nytggdtchkvyqrsttiffycdrstqapvflqetsdcsylfewrtqyacppydltecsf
kneagetydlsslsrysdnweavtgtgstehylinvckslspqagsdpcppeaavcllgg
pkpvnlgrvrdspqwsqgltllkyvdgdlcpdqirkksttirftcseshvnsrpmfisav
edceytfswptaaacavksnvhddcqvtnpatghlfdlsslsgragftaaysekglvyls
vcgdnencangvgacfgqtrisvgkaskrltyvdqvlqlvyeggspcpsktglsyksvis
fvcrpevgptnrpmlisldkrtctlffswhtplaceqttecsvrngsslidlsplihrtg
gyeaydeseddgsdtspdfyinicqplnpmhglacpagtavckvpvdgppidigrvagpp
ilnpianevylnfesstpcladrhfnytslitfhckrgvsmgtpkllrtsvcdfvfewet
plvcpdevktdgcsltdeqlyysfnlsslskstfkvtrgphtysvgvctaaagldeggck
dgavcllsgskgasfgrlasmkldyrhqdeavilsyangdtcppetedgepcvfpfvfng
ksyeecvvesrarlwcattanydrdhewgfckhstshrtsviifkcdedadvgrpqvfse
vrgcevtfewktkvvcppkkmeckfvqkhrtydlrllssltgswsfvhngasyyinlcqk
iykgpqdcserasvckkstsgevqvlglvhtqkldvvddrvivtyskghycgdnktasav
ieltcaktvgrpsftrfdvdsctyhfswdsraacavkpqevqmvngtitnpangrsfslg
diyfkrfsasgdvrtngdryiyeiqlssitgssspacsgasicqrkandqhfsrkvgtsn
qtryyvqdgdldvvftssskcgkdktksvsstiffhcdplvkdgipefshetadcqylfs
whtsavcplgagfdeeiagddaqehkglsersqavgavlslllvaltaclltlllykker
remvmsrltnccrrsanvsykyskvnkeeeadenetewlmeeiqppaprpgkegqenghv
aaksvraadtlsalhgdeqdsedevltlpevkvrppgrapgaeggpplrplprkappplr
addrvglvrgeparrgrpraaatpistfhddsdedllhv

    Sequence, based on observed residues (ATOM records):
    >6um2A (A:)
allcgvsdgkqrfdlsalarhseleqnweavdgsqreaekkhffinichrvlqtgqargc
pedaavcavdkngsknlgrfissptrekgniqlsysdgdecgggqkiitnitlmckpgdl
esapvlttsradgcfyefewrtaaacvlsrtegdnctvfdsqagfsfdltpltkkdaykv
etdkyefhinvcgpvsvgacppdsgacqvsrsdrkswnlgrsnaklsyydgmiqltyrdg
tpynnekrtpratlitflcdrdagvgfpeyqeednstynfrwytsyacpeeplecivtdp
vtldqydlsrlakseggpggnwysldnggarstwrkyyinvcrplnpvpgcdryasacqm
kyqgeqgsysetvsisnlgvaktgpmvedsgsllleyvngsacttsdqrrttyttrihlv
cstgslythpifslnwecvvsflwntaaacpirittdidqvcsikdpnsgyvfdlnplnn
srgyvvlgigktflfnvcgdmpacgtldgkpasgceaevlvglekslqlstegfitlnyt
glpshpngradafiirfvcnddvypgtpkflhqdidsslgirdtffefetalacvpspvd
cqvtdpagneydlsglskarkpwtavdtfdegkkrtfylsvctplpyipgchgtavgccl
vtedsklnlgvvqispqvgangslslvyvngdkcknqrfstrinlecahttgsptfqlqn
dceyvflwrtveacpvvraegdycevrdprhgnlynliplglndtvvrageytyyfrvcg
eltsgvcptsdkskvisscqekrgpqgfqkvaglfnqkltyengvlkmnytggdtchkvy
qrsttiffycdrstqapvflqetsdcsylfewrtqyacppydltecsfkneagetydlss
lsrysdnweavtgtgstehylinvckslspqagsdpcppeaavcllggpkpvnlgrvrds
pqwsqgltllkyvdgdlcpdqirkksttirftcseshvnsrpmfisavedceytfswpta
aacavksnvhddcqvtnpatghlfdlsslsgragftaaysekglvylsvcgdnencangv
gacfgqtrisvgkaskrltyvdqvlqlvyeggspcpsktglsyksvisfvcrpevgptnr
pmlisldkrtctlffswhtplaceqttecsvrngsslidlsplihrtggyeaydeseddg
pdfyinicqplnpmhglacpagtavckvpvdgppidigrvagppilnpianevylnfess
tpcladrhfnytslitfhckrgvsmgtpkllrtsvcdfvfewetplvcpdevktdgcslt
deqlyysfnlsslskstfkvtrgphtysvgvctaaagldeggckdgavcllsgskgasfg
rlasmkldyrhqdeavilsyangdtcppetedgepcvfpfvfngksyeecvvesrarlwc
attanydrdhewgfckhstshrtsviifkcdedadvgrpqvfsevrgcevtfewktkvvc
ppkkmeckfvqkhrtydlrllssltgswsfvhngasyyinlcqkiykgpqdcserasvck
kstsgevqvlglvhtqkldvvddrvivtyskghycgdnktasavieltcaktvgrpsftr
fdvdsctyhfswdsraac

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6um2B (B:)
mayrpsetlcggelvdtlqfvcgdrgfyfsrpasrvsrrsrgiveeccfrscdlallety
catpakse

    Sequence, based on observed residues (ATOM records):
    >6um2B (B:)
setlcggelvdtlqfvcgdrgfyfsgiveeccfrscdlalletycatp