PDB entry 6ulg

View 6ulg on RCSB PDB site
Description: cryo-em structure of the flcn-fnip2-rag-ragulator complex
Deposited on 2019-10-08, released 2019-11-20
The last revision was dated 2019-12-11, with a file datestamp of 2019-12-06.
Experiment type: EM
Resolution: 3.31 Å
R-factor: N/A
AEROSPACI score: 0.09 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ragulator complex protein LAMTOR3
    Species: Homo sapiens [TaxId:9606]
    Gene: LAMTOR3, MAP2K1IP1, MAPKSP1, PRO2783
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Ragulator complex protein LAMTOR2
    Species: Homo sapiens [TaxId:9606]
    Gene: LAMTOR2, MAPBPIP, ROBLD3, HSPC003
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Ragulator complex protein LAMTOR5
    Species: Homo sapiens [TaxId:9606]
    Gene: LAMTOR5, HBXIP, XIP
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Ragulator complex protein LAMTOR4
    Species: Homo sapiens [TaxId:9606]
    Gene: LAMTOR4, C7orf59
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Ragulator complex protein LAMTOR1
    Species: Homo sapiens [TaxId:9606]
    Gene: LAMTOR1, C11orf59, PDRO, PP7157
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Ras-related GTP-binding protein A
    Species: Homo sapiens [TaxId:9606]
    Gene: RRAGA
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q7L523
      • engineered mutation (20)
  • Chain 'G':
    Compound: Ras-related GTP-binding protein C
    Species: Homo sapiens [TaxId:9606]
    Gene: RRAGC
    Database cross-references and differences (RAF-indexed):
  • Chain 'L':
    Compound: Folliculin
    Species: Homo sapiens [TaxId:9606]
    Gene: FLCN, BHD
    Database cross-references and differences (RAF-indexed):
  • Chain 'N':
    Compound: Folliculin-interacting protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: FNIP2, FNIPL, KIAA1450, MAPO1
    Database cross-references and differences (RAF-indexed):
  • Heterogens: GDP, GNP, MG

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6ulgA (A:)
    maddlkrflykklpsveglhaivvsdrdgvpvikvandnapehalrpgflstfalatdqg
    sklglsknksiicyyntyqvvqfnrlplvvsfiasssantglivslekelaplfeelrqv
    vevs
    

    Sequence, based on observed residues (ATOM records):
    >6ulgA (A:)
    addlkrflykklpsveglhaivvsdrdgvpvikvandnapehalrpgflstfalatdqgs
    klglsknksiicyyntyqvvqfnrlplvvsfiasssantglivslekelaplfeelrqvv
    e
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records:
    >6ulgB (B:)
    mlrpkaltqvlsqantggvqstlllnnegsllaysgygdtdarvtaaiasniwaaydrng
    nqafnednlkfilmdcmegrvaitrvanlllcmyaketvgfgmlkakaqalvqyleeplt
    qvaas
    

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records:
    >6ulgC (C:)
    meatleqhledtmknpsivgvlctdsqglnlgcrgtlsdehagvisvlaqqaakltsdpt
    dipvvclesdngnimiqkhdgitvavhkmas
    

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6ulgD (D:)
    mtsaltqgleripdqlgylvlsegavlassgdlendeqaasaiselvstacgfrlhrgmn
    vpfkrlsvvfgehtllvtvsgqrvfvvkrqnrgrepidv
    

    Sequence, based on observed residues (ATOM records):
    >6ulgD (D:)
    altqgleripdqlgylvlsegavlassgdlendeqaasaiselvstacgfrlhvpfkrls
    vvfgehtllvtvsgqrvfvvkrqnr
    

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6ulgE (E:)
    mgccyssenedsdqdreerkllldpsspptkalngaepnyhslpsartdeqallssilak
    tasniidvsaadsqgmeqheymdrarqystrlavlssslthwkklpplpsltsqphqvla
    sepipfsdlqqvsriaayaysalsqirvdakeelvvqfgip
    

    Sequence, based on observed residues (ATOM records):
    >6ulgE (E:)
    deqallssilaktasniidvsameqheymdrarqystrlavlssslthwkklpplpslts
    qphqvlasepipfsdlqqvsriaayaysalsqirvdakeelvvqfg
    

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6ulgF (F:)
    mpntamkkkvllmgksgsgknsmrsiifanyiardtrrlgatidvehshvrflgnlvlnl
    wdcggqdtfmenyftsqrdnifrnvevliyvfdvesrelekdmhyyqscleailqnspda
    kifclvhkmdlvqedqrdlifkereedlrrlsrplecacfrtsiwdetlykawssivyql
    ipnvqqlemnlrnfaqiieadevllferatflvishyqckeqrdvhrfekisniikqfkl
    scsklaasfqsmevrnsnfaafidiftsntyvmvvmsdpsipsaatlinirnarkhfekl
    ervdgpkhsllmr
    

    Sequence, based on observed residues (ATOM records):
    >6ulgF (F:)
    kkkvllmgksgsgknsmrsiifavrflgnlvlnlwdcggqdtfmenyftsqrdnifrnve
    vliyvfdvesrelekdmhyyqscleailqnspdakifclvhkmdlvqedqrdlifkeree
    dlrrlsrplecacfrtsiwdetlykawssivyqlipnvqqlemnlrnfaqiieadevllf
    eratflvishyqckeqrdvhrfekisniikqfklscsklaasfqsmevrnsnfaafidif
    tsntyvmvvmsdpsipsaatlinirnarkhfek
    

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6ulgG (G:)
    mslqygaeetplagsygaadsfpkdfgygveeeeeeaaaagggvgagagggcgpggadss
    kprillmglrrsgkssiqkvvfhkmspnetlflestnkiykddisnssfvnfqiwdfpgq
    mdffdptfdyemifrgtgaliyvidaqddymealtrlhitvskaykvnpdmnfevfihkv
    dglsddhkietqrdihqranddladagleklhlsfyltsiydhsifeafskvvqklipql
    ptlenllnifisnsgiekaflfdvvskiyiatdsspvdmqsyelccdmidvvidvsciyg
    lkedgsgsaydkesmaiiklnnttvlylkevtkflalvcilreesferkglidynfhcfr
    kaihevfevgvtshrscghqtsasslkalthngtprnai
    

    Sequence, based on observed residues (ATOM records):
    >6ulgG (G:)
    kprillmglrrsgkssiqkvvfhkmspnetlflestnkiykddisnssfvnfqiwdfpgq
    mdffdptfdyemifrgtgaliyvidaqddymealtrlhitvskaykvnpdmnfevfihkv
    dglsddhkietqrdihqranddladagleklhlsfyltsiydhsifeafskvvqklipql
    ptlenllnifisnsgiekaflfdvvskiyiatdsspvdmqsyelccdmidvvidvsciyg
    lkedgsgsaydkesmaiiklnnttvlylkevtkflalvcilreesferkglidynfhcfr
    kaihevfevg
    

  • Chain 'L':
    Sequence, based on SEQRES records:
    >6ulgL (L:)
    mnaivalchfcelhgprtlfctevlhaplpqgdgnedspgqgeqaeeeeggiqmnsrmra
    hspaegasvessspgpkksdmcegcrslaaghpgyishdketsikyvshqhpshpqlfsi
    vrqacvrslscevcpgregpiffgdeqhgfvfshtffikdslargfqrwysiitimmdri
    ylinswpfllgkvrgiidelqgkalkvfeaeqfgcpqraqrmntaftpflhqrngnaars
    ltsltsddnlwaclhtsfawllkacgsrltekllegaptedtlvqmekladleeeseswd
    nseaeeeekapvlpestegreltqgpaessslsgcgswqprklpvfkslrhmrqvlgaps
    frmlawhvlmgnqviwksrdvdlvqsafevlrtmlpvgcvriipyssqyeeayrcnflgl
    sphvqipphvlssefavivevhaaarstlhpvgceddqslskyefvvtsgspvaadrvgp
    tilnkieaaltnqnlsvdvvdqclvclkeewmnkvkvlfkftkvdsrpkedtqkllsilg
    aseednvkllkfwmtglsktykshlmstvrsptasesrn
    

    Sequence, based on observed residues (ATOM records):
    >6ulgL (L:)
    naivalchfcelhgprtlfctevlcegcrslaaghpgyishdketsikyvshqhpshpql
    fsivrqacvrslscevcpgregpiffgdeqhgfvfshtffikdslargfqrwysiitimm
    driylinswpfllgkvrgiidelqgkalkvfeaeqfgcpqraqrmntaftpflhqrngna
    arsltsltsddnlwaclhtsfawllkacgsrltekllegaptedtlvqmekladleelsg
    cgswqprklpvfkslrhmrqvlgapsfrmlawhvlmgnqviwksrdvdlvqsafevlrtm
    lpvgcvriipyssqyeeayrcnflglsphvqipphvlssefavivevhslskyefvvtsg
    spvaadrvgptilnkieaaltnqnlsvdvvdqclvclkeewmnkvkvlfkftkvdsrpke
    dtqkllsilgaseednvkllkfwmtglsktykshlmst
    

  • Chain 'N':
    Sequence, based on SEQRES records:
    >6ulgN (N:)
    maptllqklfnkrgssgssaaasaqgrapkegpafswscsefdlneirlivyqdcdrrgr
    qvlfdskavqkieevtaqktedvpikisakccqgsssvsssssssisshsssggsshhak
    eqlpkyqytrpasdvnmlgemmfgsvamsykgstlkihyirsppqlmiskvfsarmgsfc
    gstnnlqdsfeyinqdpnlgklntnqnslgpcrtgsnlahstpvdmpsrgqnedrdsgia
    rsaslssllitpfpspssstsssssyqrrwlrsqttslengiiprrstdetfslaeetcs
    snpamvrrkkiaisiifslcekeeaqrnfqdfffshfplfeshmnrlksaiekamiscrk
    iaesslrvqfyvsrlmealgefrgtiwnlysvpriaepvwltmmsgtleknqlcqrflke
    ftllieqinknqffaalltavltyhlawvptvmpvdhppikafsekrtsqsvnmlakthp
    ynplwaqlgdlygaigspvrltrtvvvgkqkdlvqrilyvltyflrcselqenqltwsgn
    hgegdqvlngskiitalekgeveeseyvvitvrnepalvppilpptaaerhnpwptgfpe
    cpegtdsrdlglkpdkeanrrpeqgseacsagclgpasdaswkpqnafcgdeknkeapqd
    gssrlpscevlgagmkmdqqavcellkvemptrlpdrsvawpcpdrhlrekpslekvtfq
    igsfaspesdfesrmkkmeervkacgpsleaseaadvaqdpqvsrspfkpgfqenvccpq
    nrlsegdegesdkgfaedrgsrndmaadiagqlshaadlgtashgaggtggrrleatrgl
    yvkaaegpvlepvaprcvqrgpglvaganipcgddnkkanfrtegdiprnessdsalgds
    ddeacasamldlghggdrtggslevelplprsqsistqnvrnfgrsllagycptympdlv
    lhgtgsdeklkqclvadlvhtvhhpvldepiaeavciiadtdkwsvqvatsqrkvtdnmk
    lgqdvlvssqvssllqsilqlyklhlpadfcimhledrlqemylkskmlseylrghtrvh
    vkelgvvlgiesndlplltaiasthspyvaqill
    

    Sequence, based on observed residues (ATOM records):
    >6ulgN (N:)
    efdlneirlivyqdcdrrgrqvlfdskavqkielpkyqytrpasdvnmlgemmfgsvams
    ykgstlkihyirsppqlmiskvfsarmgsfcgsrkkiaisiifslcekeeaqrnfqdfff
    shfplfeshmnrlksaiekamiscrkiaesslrvqfyvsrlmealgefrgtiwnlysvpr
    iaepvwltmmsgtleknqlcqrflkeftllieqinknqffaalltavltyhlawvptvmp
    hpynplwaqlgdlygaigspvrltrtvvvgkqkdlvqrilyvltyflrcselqenqltws
    lngskiitalekgeveeseyvvitvrnempdlvlhgtgsdeklkqclvadlvhtvhhpvl
    depiaeavciiadtdkwsvqvatsqrkvtdnmklgqdvlvssqvssllqsilqlyklhlp
    adfcimhledrlqemylkskmlseylrghtrvhvkelgvvlgiesndlplltaiasthsp
    yva