PDB entry 6ul8

View 6ul8 on RCSB PDB site
Description: RIP2 kinase catalytic domain complex with (5S,6S,8R)-2-(benzo[d]thiazol-5-yl)-6-hydroxy-4,5,6,7,8,9-hexahydro-5,8-methanopyrazolo[1,5-a][1,3]diazocine-3-carboxamide
Class: transferase
Keywords: Kinase, TRANSFERASE
Deposited on 2019-10-07, released 2019-12-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-04, with a file datestamp of 2019-11-29.
Experiment type: XRAY
Resolution: 2.68 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: receptor-interacting serine/threonine-protein kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: RIPK2, CARDIAK, RICK, RIP2, UNQ277/PRO314/PRO34092
    Database cross-references and differences (RAF-indexed):
    • Uniprot O43353 (0-305)
      • engineered mutation (2)
      • engineered mutation (163)
    Domains in SCOPe 2.08: d6ul8a_
  • Chain 'B':
    Compound: receptor-interacting serine/threonine-protein kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: RIPK2, CARDIAK, RICK, RIP2, UNQ277/PRO314/PRO34092
    Database cross-references and differences (RAF-indexed):
    • Uniprot O43353 (0-305)
      • engineered mutation (2)
      • engineered mutation (163)
    Domains in SCOPe 2.08: d6ul8b_
  • Heterogens: Q9J, CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6ul8A (A:)
aissalptipyhkladlrylsrgasgtvssarhadwrvqvavkhlhihtplldserkdvl
reaeilhkarfsyilpilgicnepeflgivteympngslnellhrkteypdvawplrfri
lheialgvnylhnmtppllhhdlktqnilldnefhvkiadfglckwrmmslsqsrssksa
peggtiiymppenyepgqksrasikhdiysyavitwevlsrkqpfedvtnplqimysvsq
ghrpvineeslpydiphrarmisliesgwaqnpderpsflkclielepvlrtfeeitfle
aviqlk

    Sequence, based on observed residues (ATOM records): (download) 
    >6ul8A (A:)
aissalptipyhkladlrylsrgasgtvssarhadwrvqvavkhlhilldserkdvlrea
eilhkarfsyilpilgicnepeflgivteympngslnellhrkteypdvawplrfrilhe
ialgvnylhnmtppllhhdlktqnilldnefhvkiadfglckwgtiiymppenyesikhd
iysyavitwevlsrkqpfedvtnplqimysvsqghrpvineeslpydiphrarmislies
gwaqnpderpsflkclielepvlrtfeeitfleaviqlk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6ul8B (B:)
aissalptipyhkladlrylsrgasgtvssarhadwrvqvavkhlhihtplldserkdvl
reaeilhkarfsyilpilgicnepeflgivteympngslnellhrkteypdvawplrfri
lheialgvnylhnmtppllhhdlktqnilldnefhvkiadfglckwrmmslsqsrssksa
peggtiiymppenyepgqksrasikhdiysyavitwevlsrkqpfedvtnplqimysvsq
ghrpvineeslpydiphrarmisliesgwaqnpderpsflkclielepvlrtfeeitfle
aviqlk

    Sequence, based on observed residues (ATOM records): (download) 
    >6ul8B (B:)
aissalptipyhkladlrylsrgasgtvssarhadwrvqvavkhlldserkdvlreaeil
hkarfsyilpilgicnepeflgivteympngslnellhrkteypdvawplrfrilheial
gvnylhnmtppllhhdlktqnilldnefhvkiadfglckwgtiiymppenyepgqksras
ikhdiysyavitwevlsrkqpfedvtnplqimysvsqghrpvineeslpydiphrarmis
liesgwaqnpderpsflkclielepvlrtfeeitfleaviqlk