PDB entry 6uk6

View 6uk6 on RCSB PDB site
Description: crystal structure of human gac in complex with inhibitor upgl00018
Deposited on 2019-10-04, released 2020-10-07
The last revision was dated 2020-10-07, with a file datestamp of 2020-10-02.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glutaminase kidney isoform, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: GLS, GLS1, KIAA0838
    Database cross-references and differences (RAF-indexed):
    • Uniprot O94925
      • conflict (196)
  • Chain 'B':
    Compound: Glutaminase kidney isoform, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: GLS, GLS1, KIAA0838
    Database cross-references and differences (RAF-indexed):
    • Uniprot O94925
      • conflict (196)
  • Chain 'C':
    Compound: Glutaminase kidney isoform, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: GLS, GLS1, KIAA0838
    Database cross-references and differences (RAF-indexed):
    • Uniprot O94925
      • conflict (196)
  • Chain 'D':
    Compound: Glutaminase kidney isoform, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: GLS, GLS1, KIAA0838
    Database cross-references and differences (RAF-indexed):
    • Uniprot O94925
      • conflict (196)
  • Heterogens: Q9S

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6uk6A (A:)
lssspseilqelgkgsthpqpgvsppaapaapgpkdgpgetdafgnsegkelvasgenki
kqgllpsledllfytiaegqekipvhkfitalkstglrtsdprlkecmdmlrltlqttsd
gvmldkdlfkkcvqsnivlltqafrrkfvipdfmsftshidelyesakkqsggkvadyip
qlakfspdlwgvsvctadgqrhstgdtkvpfclqscvkplkyaiavndlgteyvhryvgk
epsglrfnklflneddkphnpmvnagaivvtslikqgvnnaekfdyvmqflnkmagneyv
gfsnatfqseresgdrnfaigyylkekkcfpegtdmvgildfyfqlcsievtcesasvma
atlanggfcpitgervlspeavrntlslmhscgmydfsgqfafhvglpaksgvaggillv
vpnvmgmmcwsppldkmgnsvkgihfchdlvslcnfhnydnlrhfakkldprreggdqrh
sfgpldyeslqqelalketvwkkvspesnedisttvvyrmeslgeks

    Sequence, based on observed residues (ATOM records):
    >6uk6A (A:)
psledllfytiaegqekipvhkfitalkstglrtsdprlkecmdmlrltlqttsdgvmld
kdlfkkcvqsnivlltqafrrkfvipdfmsftshidelyesakkqsggkvadyipspdlw
gvsvctadgqrhstgdtkvpfclqscvkplkyaiavndlgteyvhryvgkepsglrfnkl
flneddkphnpmvnagaivvtslikqgvnnaekfdyvmqflnkmagneyvgfsnatfqse
resgdrnfaigyylkekkcfpegtdmvgildfyfqlcsievtcesasvmaatlanggfcp
itgervlspeavrntlslmhscgmydfsgqfafhvglpaksgvaggillvvpnvmgmmcw
sppldkmgnsvkgihfchdlvslcnfhnydnlrhfakkldprre

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6uk6B (B:)
lssspseilqelgkgsthpqpgvsppaapaapgpkdgpgetdafgnsegkelvasgenki
kqgllpsledllfytiaegqekipvhkfitalkstglrtsdprlkecmdmlrltlqttsd
gvmldkdlfkkcvqsnivlltqafrrkfvipdfmsftshidelyesakkqsggkvadyip
qlakfspdlwgvsvctadgqrhstgdtkvpfclqscvkplkyaiavndlgteyvhryvgk
epsglrfnklflneddkphnpmvnagaivvtslikqgvnnaekfdyvmqflnkmagneyv
gfsnatfqseresgdrnfaigyylkekkcfpegtdmvgildfyfqlcsievtcesasvma
atlanggfcpitgervlspeavrntlslmhscgmydfsgqfafhvglpaksgvaggillv
vpnvmgmmcwsppldkmgnsvkgihfchdlvslcnfhnydnlrhfakkldprreggdqrh
sfgpldyeslqqelalketvwkkvspesnedisttvvyrmeslgeks

    Sequence, based on observed residues (ATOM records):
    >6uk6B (B:)
psledllfytiaegqekipvhkfitalkstglrtsdprlkecmdmlrltlvmldkdlfkk
cvqsnivlltqafrrkfvipdfmsftshidelyesakkqsggkvadyippdlwgvsvcta
dgqrhstgdtkvpfclqscvkplkyaiavndlgteyvhryvgkepsglrfnklflneddk
phnpmvnagaivvtslikqgvnnaekfdyvmqflnkmagneyvgfsnatfqseresgdrn
faigyylkekkcfpegtdmvgildfyfqlcsievtcesasvmaatlanggfcpitgervl
speavrntlslmhscgmydfsgqfafhvglpaksgvaggillvvpnvmgmmcwsppldkm
gnsvkgihfchdlvslcnfhnydnlrhfakkldprreg

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6uk6C (C:)
lssspseilqelgkgsthpqpgvsppaapaapgpkdgpgetdafgnsegkelvasgenki
kqgllpsledllfytiaegqekipvhkfitalkstglrtsdprlkecmdmlrltlqttsd
gvmldkdlfkkcvqsnivlltqafrrkfvipdfmsftshidelyesakkqsggkvadyip
qlakfspdlwgvsvctadgqrhstgdtkvpfclqscvkplkyaiavndlgteyvhryvgk
epsglrfnklflneddkphnpmvnagaivvtslikqgvnnaekfdyvmqflnkmagneyv
gfsnatfqseresgdrnfaigyylkekkcfpegtdmvgildfyfqlcsievtcesasvma
atlanggfcpitgervlspeavrntlslmhscgmydfsgqfafhvglpaksgvaggillv
vpnvmgmmcwsppldkmgnsvkgihfchdlvslcnfhnydnlrhfakkldprreggdqrh
sfgpldyeslqqelalketvwkkvspesnedisttvvyrmeslgeks

    Sequence, based on observed residues (ATOM records):
    >6uk6C (C:)
psledllfytiaegqekipvhkfitalkstglrtsdprlkecmdmlrltlqttsdgvmld
kdlfkkcvqsnivlltqafrrkfvipdfmsftshidelyesakkqsggkvadspdlwgvs
vctadgqrhstgdtkvpfclqscvkplkyaiavndlgteyvhryvgkepsglrfnklfln
eddkphnpmvnagaivvtslikqgvnnaekfdyvmqflnkmagneyvgfsnatfqseres
gdrnfaigyylkekkcfpegtdmvgildfyfqlcsievtcesasvmaatlanggfcpitg
ervlspeavrntlslmhscgmydfsgqfafhvglpaksgvaggillvvpnvmgmmcwspp
ldkmgnsvkgihfchdlvslcnfhnydnlrhfakkldprreg

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6uk6D (D:)
lssspseilqelgkgsthpqpgvsppaapaapgpkdgpgetdafgnsegkelvasgenki
kqgllpsledllfytiaegqekipvhkfitalkstglrtsdprlkecmdmlrltlqttsd
gvmldkdlfkkcvqsnivlltqafrrkfvipdfmsftshidelyesakkqsggkvadyip
qlakfspdlwgvsvctadgqrhstgdtkvpfclqscvkplkyaiavndlgteyvhryvgk
epsglrfnklflneddkphnpmvnagaivvtslikqgvnnaekfdyvmqflnkmagneyv
gfsnatfqseresgdrnfaigyylkekkcfpegtdmvgildfyfqlcsievtcesasvma
atlanggfcpitgervlspeavrntlslmhscgmydfsgqfafhvglpaksgvaggillv
vpnvmgmmcwsppldkmgnsvkgihfchdlvslcnfhnydnlrhfakkldprreggdqrh
sfgpldyeslqqelalketvwkkvspesnedisttvvyrmeslgeks

    Sequence, based on observed residues (ATOM records):
    >6uk6D (D:)
psledllfytiaegqekipvhkfitalkstglrtsdprlkecmdmlrltvmldkdlfkkc
vqsnivlltqafrrkfvipdfmsftshidelyesakkqsggkvadyispdlwgvsvctad
gqrhstgdtkvpfclqscvkplkyaiavndlgteyvhryvgkepsglrfnklflneddkp
hnpmvnagaivvtslikqgvnnaekfdyvmqflnkmagneyvgfsnatfqseresgdrnf
aigyylkekkcfpegtdmvgildfyfqlcsievtcesasvmaatlanggfcpitgervls
peavrntlslmhscgmydfsgqfafhvglpaksgvaggillvvpnvmgmmcwsppldkmg
nsvkgihfchdlvslcnfhnydnlrhfakkldprreg