PDB entry 6ujg

View 6ujg on RCSB PDB site
Description: crystal structure of human gac in complex with inhibitor upgl00012
Deposited on 2019-10-03, released 2020-10-07
The last revision was dated 2020-10-07, with a file datestamp of 2020-10-02.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glutaminase kidney isoform, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: GLS, GLS1, KIAA0838
    Database cross-references and differences (RAF-indexed):
    • Uniprot O94925
      • conflict (196)
  • Chain 'B':
    Compound: Glutaminase kidney isoform, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: GLS, GLS1, KIAA0838
    Database cross-references and differences (RAF-indexed):
    • Uniprot O94925
      • conflict (196)
  • Chain 'C':
    Compound: Glutaminase kidney isoform, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: GLS, GLS1, KIAA0838
    Database cross-references and differences (RAF-indexed):
    • Uniprot O94925
      • conflict (196)
  • Chain 'D':
    Compound: Glutaminase kidney isoform, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: GLS, GLS1, KIAA0838
    Database cross-references and differences (RAF-indexed):
    • Uniprot O94925
      • conflict (196)
  • Chain 'E':
    Compound: Glutaminase kidney isoform, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: GLS, GLS1, KIAA0838
    Database cross-references and differences (RAF-indexed):
    • Uniprot O94925
      • conflict (196)
  • Chain 'F':
    Compound: Glutaminase kidney isoform, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: GLS, GLS1, KIAA0838
    Database cross-references and differences (RAF-indexed):
    • Uniprot O94925
      • conflict (196)
  • Chain 'G':
    Compound: Glutaminase kidney isoform, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: GLS, GLS1, KIAA0838
    Database cross-references and differences (RAF-indexed):
    • Uniprot O94925
      • conflict (196)
  • Chain 'H':
    Compound: Glutaminase kidney isoform, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: GLS, GLS1, KIAA0838
    Database cross-references and differences (RAF-indexed):
    • Uniprot O94925
      • conflict (196)
  • Heterogens: Q9A

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6ujgA (A:)
lssspseilqelgkgsthpqpgvsppaapaapgpkdgpgetdafgnsegkelvasgenki
kqgllpsledllfytiaegqekipvhkfitalkstglrtsdprlkecmdmlrltlqttsd
gvmldkdlfkkcvqsnivlltqafrrkfvipdfmsftshidelyesakkqsggkvadyip
qlakfspdlwgvsvctadgqrhstgdtkvpfclqscvkplkyaiavndlgteyvhryvgk
epsglrfnklflneddkphnpmvnagaivvtslikqgvnnaekfdyvmqflnkmagneyv
gfsnatfqseresgdrnfaigyylkekkcfpegtdmvgildfyfqlcsievtcesasvma
atlanggfcpitgervlspeavrntlslmhscgmydfsgqfafhvglpaksgvaggillv
vpnvmgmmcwsppldkmgnsvkgihfchdlvslcnfhnydnlrhfakkldprreggdqrh
sfgpldyeslqqelalketvwkkvspesnedisttvvyrmeslgeks

    Sequence, based on observed residues (ATOM records):
    >6ujgA (A:)
psledllfytiaegqekipvhkfitalkstglrtsdprlkecmdmlrltlqttsdgvmld
kdlfkkcvqsnivlltqafrrkfvipdfmsftshidelyesakkqsggkvadyipqlakf
spdlwgvsvctadgqrhstgdtkvpfclqscvkplkyaiavndlgteyvhryvgkepsgl
rfnklflneddkphnpmvnagaivvtslikqgvnnaekfdyvmqflnkmagneyvgfsna
tfqseresgdrnfaigyylkekkcfpegtdmvgildfyfqlcsievtcesasvmaatlan
ggfcpitgervlspeavrntlslmhscgmydfsgqfafhvglpaksgvaggillvvpnvm
gmmcwsppldkmgnsvkgihfchdlvslcnfhnydnlrhfakkldprreg

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6ujgB (B:)
lssspseilqelgkgsthpqpgvsppaapaapgpkdgpgetdafgnsegkelvasgenki
kqgllpsledllfytiaegqekipvhkfitalkstglrtsdprlkecmdmlrltlqttsd
gvmldkdlfkkcvqsnivlltqafrrkfvipdfmsftshidelyesakkqsggkvadyip
qlakfspdlwgvsvctadgqrhstgdtkvpfclqscvkplkyaiavndlgteyvhryvgk
epsglrfnklflneddkphnpmvnagaivvtslikqgvnnaekfdyvmqflnkmagneyv
gfsnatfqseresgdrnfaigyylkekkcfpegtdmvgildfyfqlcsievtcesasvma
atlanggfcpitgervlspeavrntlslmhscgmydfsgqfafhvglpaksgvaggillv
vpnvmgmmcwsppldkmgnsvkgihfchdlvslcnfhnydnlrhfakkldprreggdqrh
sfgpldyeslqqelalketvwkkvspesnedisttvvyrmeslgeks

    Sequence, based on observed residues (ATOM records):
    >6ujgB (B:)
psledllfytiaegqekipvhkfitalkstglrtsdprlkecmdmlrltlqttsdgvmld
kdlfkkcvqsnivlltqafrrkfvipdfmsftshidelyesakkqsggkvadyipqlakf
spdlwgvsvctadgqrhstgdtkvpfclqscvkplkyaiavndlgteyvhryvgkepsgl
rfnklflneddkphnpmvnagaivvtslikqgvnnaekfdyvmqflnkmagneyvgfsna
tfqseresgdrnfaigyylkekkcfpegtdmvgildfyfqlcsievtcesasvmaatlan
ggfcpitgervlspeavrntlslmhscgmydfsgqfafhvglpaksgvaggillvvpnvm
gmmcwsppldkmgnsvkgihfchdlvslcnfhnydnlrhfakkldprreg

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6ujgC (C:)
lssspseilqelgkgsthpqpgvsppaapaapgpkdgpgetdafgnsegkelvasgenki
kqgllpsledllfytiaegqekipvhkfitalkstglrtsdprlkecmdmlrltlqttsd
gvmldkdlfkkcvqsnivlltqafrrkfvipdfmsftshidelyesakkqsggkvadyip
qlakfspdlwgvsvctadgqrhstgdtkvpfclqscvkplkyaiavndlgteyvhryvgk
epsglrfnklflneddkphnpmvnagaivvtslikqgvnnaekfdyvmqflnkmagneyv
gfsnatfqseresgdrnfaigyylkekkcfpegtdmvgildfyfqlcsievtcesasvma
atlanggfcpitgervlspeavrntlslmhscgmydfsgqfafhvglpaksgvaggillv
vpnvmgmmcwsppldkmgnsvkgihfchdlvslcnfhnydnlrhfakkldprreggdqrh
sfgpldyeslqqelalketvwkkvspesnedisttvvyrmeslgeks

    Sequence, based on observed residues (ATOM records):
    >6ujgC (C:)
psledllfytiaegqekipvhkfitalkstglrtsdprlkecmdmlrltlqttsdgvmld
kdlfkkcvqsnivlltqafrrkfvipdfmsftshidelyesakkqsggkvadyipqlakf
spdlwgvsvctadgqrhstgdtkvpfclqscvkplkyaiavndlgteyvhryvgkepsgl
rfnklflneddkphnpmvnagaivvtslikqgvnnaekfdyvmqflnkmagneyvgfsna
tfqseresgdrnfaigyylkekkcfpegtdmvgildfyfqlcsievtcesasvmaatlan
ggfcpitgervlspeavrntlslmhscgmydfsgqfafhvglpaksgvaggillvvpnvm
gmmcwsppldkmgnsvkgihfchdlvslcnfhnydnlrhfakkldprreg

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6ujgD (D:)
lssspseilqelgkgsthpqpgvsppaapaapgpkdgpgetdafgnsegkelvasgenki
kqgllpsledllfytiaegqekipvhkfitalkstglrtsdprlkecmdmlrltlqttsd
gvmldkdlfkkcvqsnivlltqafrrkfvipdfmsftshidelyesakkqsggkvadyip
qlakfspdlwgvsvctadgqrhstgdtkvpfclqscvkplkyaiavndlgteyvhryvgk
epsglrfnklflneddkphnpmvnagaivvtslikqgvnnaekfdyvmqflnkmagneyv
gfsnatfqseresgdrnfaigyylkekkcfpegtdmvgildfyfqlcsievtcesasvma
atlanggfcpitgervlspeavrntlslmhscgmydfsgqfafhvglpaksgvaggillv
vpnvmgmmcwsppldkmgnsvkgihfchdlvslcnfhnydnlrhfakkldprreggdqrh
sfgpldyeslqqelalketvwkkvspesnedisttvvyrmeslgeks

    Sequence, based on observed residues (ATOM records):
    >6ujgD (D:)
psledllfytiaegqekipvhkfitalkstglrtsdprlkecmdmlrltlqttsdgvmld
kdlfkkcvqsnivlltqafrrkfvipdfmsftshidelyesakkqsggkvadyipqlakf
spdlwgvsvctadgqrhstgdtkvpfclqscvkplkyaiavndlgteyvhryvgkepsgl
rfnklflneddkphnpmvnagaivvtslikqgvnnaekfdyvmqflnkmagneyvgfsna
tfqseresgdrnfaigyylkekkcfpegtdmvgildfyfqlcsievtcesasvmaatlan
ggfcpitgervlspeavrntlslmhscgmydfsgqfafhvglpaksgvaggillvvpnvm
gmmcwsppldkmgnsvkgihfchdlvslcnfhnydnlrhfakkldprreg

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6ujgE (E:)
lssspseilqelgkgsthpqpgvsppaapaapgpkdgpgetdafgnsegkelvasgenki
kqgllpsledllfytiaegqekipvhkfitalkstglrtsdprlkecmdmlrltlqttsd
gvmldkdlfkkcvqsnivlltqafrrkfvipdfmsftshidelyesakkqsggkvadyip
qlakfspdlwgvsvctadgqrhstgdtkvpfclqscvkplkyaiavndlgteyvhryvgk
epsglrfnklflneddkphnpmvnagaivvtslikqgvnnaekfdyvmqflnkmagneyv
gfsnatfqseresgdrnfaigyylkekkcfpegtdmvgildfyfqlcsievtcesasvma
atlanggfcpitgervlspeavrntlslmhscgmydfsgqfafhvglpaksgvaggillv
vpnvmgmmcwsppldkmgnsvkgihfchdlvslcnfhnydnlrhfakkldprreggdqrh
sfgpldyeslqqelalketvwkkvspesnedisttvvyrmeslgeks

    Sequence, based on observed residues (ATOM records):
    >6ujgE (E:)
psledllfytiaegqekipvhkfitalkstglrtsdprlkecmdmlrltlqttsdgvmld
kdlfkkcvqsnivlltqafrrkfvipdfmsftshidelyesakkqsggkvadyipqlakf
spdlwgvsvctadgqrhstgdtkvpfclqscvkplkyaiavndlgteyvhryvgkepsgl
rfnklflneddkphnpmvnagaivvtslikqgvnnaekfdyvmqflnkmagneyvgfsna
tfqseresgdrnfaigyylkekkcfpegtdmvgildfyfqlcsievtcesasvmaatlan
ggfcpitgervlspeavrntlslmhscgmydfsgqfafhvglpaksgvaggillvvpnvm
gmmcwsppldkmgnsvkgihfchdlvslcnfhnydnlrhfakkldprreg

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6ujgF (F:)
lssspseilqelgkgsthpqpgvsppaapaapgpkdgpgetdafgnsegkelvasgenki
kqgllpsledllfytiaegqekipvhkfitalkstglrtsdprlkecmdmlrltlqttsd
gvmldkdlfkkcvqsnivlltqafrrkfvipdfmsftshidelyesakkqsggkvadyip
qlakfspdlwgvsvctadgqrhstgdtkvpfclqscvkplkyaiavndlgteyvhryvgk
epsglrfnklflneddkphnpmvnagaivvtslikqgvnnaekfdyvmqflnkmagneyv
gfsnatfqseresgdrnfaigyylkekkcfpegtdmvgildfyfqlcsievtcesasvma
atlanggfcpitgervlspeavrntlslmhscgmydfsgqfafhvglpaksgvaggillv
vpnvmgmmcwsppldkmgnsvkgihfchdlvslcnfhnydnlrhfakkldprreggdqrh
sfgpldyeslqqelalketvwkkvspesnedisttvvyrmeslgeks

    Sequence, based on observed residues (ATOM records):
    >6ujgF (F:)
psledllfytiaegqekipvhkfitalkstglrtsdprlkecmdmlrltlqttsdgvmld
kdlfkkcvqsnivlltqafrrkfvipdfmsftshidelyesakkqsggkvadyipqlakf
spdlwgvsvctadgqrhstgdtkvpfclqscvkplkyaiavndlgteyvhryvgkepsgl
rfnklflneddkphnpmvnagaivvtslikqgvnnaekfdyvmqflnkmagneyvgfsna
tfqseresgdrnfaigyylkekkcfpegtdmvgildfyfqlcsievtcesasvmaatlan
ggfcpitgervlspeavrntlslmhscgmydfsgqfafhvglpaksgvaggillvvpnvm
gmmcwsppldkmgnsvkgihfchdlvslcnfhnydnlrhfakkldprreg

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6ujgG (G:)
lssspseilqelgkgsthpqpgvsppaapaapgpkdgpgetdafgnsegkelvasgenki
kqgllpsledllfytiaegqekipvhkfitalkstglrtsdprlkecmdmlrltlqttsd
gvmldkdlfkkcvqsnivlltqafrrkfvipdfmsftshidelyesakkqsggkvadyip
qlakfspdlwgvsvctadgqrhstgdtkvpfclqscvkplkyaiavndlgteyvhryvgk
epsglrfnklflneddkphnpmvnagaivvtslikqgvnnaekfdyvmqflnkmagneyv
gfsnatfqseresgdrnfaigyylkekkcfpegtdmvgildfyfqlcsievtcesasvma
atlanggfcpitgervlspeavrntlslmhscgmydfsgqfafhvglpaksgvaggillv
vpnvmgmmcwsppldkmgnsvkgihfchdlvslcnfhnydnlrhfakkldprreggdqrh
sfgpldyeslqqelalketvwkkvspesnedisttvvyrmeslgeks

    Sequence, based on observed residues (ATOM records):
    >6ujgG (G:)
psledllfytiaegqekipvhkfitalkstglrtsdprlkecmdmlrltlqttsdgvmld
kdlfkkcvqsnivlltqafrrkfvipdfmsftshidelyesakkqsggkvadyipqlakf
spdlwgvsvctadgqrhstgdtkvpfclqscvkplkyaiavndlgteyvhryvgkepsgl
rfnklflneddkphnpmvnagaivvtslikqgvnnaekfdyvmqflnkmagneyvgfsna
tfqseresgdrnfaigyylkekkcfpegtdmvgildfyfqlcsievtcesasvmaatlan
ggfcpitgervlspeavrntlslmhscgmydfsgqfafhvglpaksgvaggillvvpnvm
gmmcwsppldkmgnsvkgihfchdlvslcnfhnydnlrhfakkldprreg

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6ujgH (H:)
lssspseilqelgkgsthpqpgvsppaapaapgpkdgpgetdafgnsegkelvasgenki
kqgllpsledllfytiaegqekipvhkfitalkstglrtsdprlkecmdmlrltlqttsd
gvmldkdlfkkcvqsnivlltqafrrkfvipdfmsftshidelyesakkqsggkvadyip
qlakfspdlwgvsvctadgqrhstgdtkvpfclqscvkplkyaiavndlgteyvhryvgk
epsglrfnklflneddkphnpmvnagaivvtslikqgvnnaekfdyvmqflnkmagneyv
gfsnatfqseresgdrnfaigyylkekkcfpegtdmvgildfyfqlcsievtcesasvma
atlanggfcpitgervlspeavrntlslmhscgmydfsgqfafhvglpaksgvaggillv
vpnvmgmmcwsppldkmgnsvkgihfchdlvslcnfhnydnlrhfakkldprreggdqrh
sfgpldyeslqqelalketvwkkvspesnedisttvvyrmeslgeks

    Sequence, based on observed residues (ATOM records):
    >6ujgH (H:)
psledllfytiaegqekipvhkfitalkstglrtsdprlkecmdmlrltlqttsdgvmld
kdlfkkcvqsnivlltqafrrkfvipdfmsftshidelyesakkqsggkvadyipqlakf
spdlwgvsvctadgqrhstgdtkvpfclqscvkplkyaiavndlgteyvhryvgkepsgl
rfnklflneddkphnpmvnagaivvtslikqgvnnaekfdyvmqflnkmagneyvgfsna
tfqseresgdrnfaigyylkekkcfpegtdmvgildfyfqlcsievtcesasvmaatlan
ggfcpitgervlspeavrntlslmhscgmydfsgqfafhvglpaksgvaggillvvpnvm
gmmcwsppldkmgnsvkgihfchdlvslcnfhnydnlrhfakkldprreg