PDB entry 6uj0

View 6uj0 on RCSB PDB site
Description: unbound bace2 mutant structure
Deposited on 2019-10-01, released 2020-10-07
The last revision was dated 2021-04-21, with a file datestamp of 2021-04-16.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-secretase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BACE2, AEPLC, ALP56, ASP21, CDA13, UNQ418/PRO852
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y5Z0
      • engineered mutation (330)
  • Chain 'B':
    Compound: Beta-secretase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BACE2, AEPLC, ALP56, ASP21, CDA13, UNQ418/PRO852
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y5Z0 (Start-459)
      • engineered mutation (330)
  • Chain 'C':
    Compound: unidentified polypeptide
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6UJ0 (0-6)
  • Chain 'D':
    Compound: unidentified polypeptide
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6UJ0 (0-End)
  • Heterogens: HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6uj0A (A:)
mgalaralllpllaqwllraapelapapftlplrvaaatnrvvaptpgpgtpaerhadgl
alalepalaspagaanflamvdnlqgdsgrgyylemligtppqklqilvdtgssnfavag
tphsyidtyfdtersstyrskgfdvtvkytqgswtgfvgedlvtipkgfntsflvniati
fesenfflpgikwngilglayatlakpsssletffdslvtqanipnvfsmqmcgaglpva
gsgtnggslvlggiepslykgdiwytpikeewyyqieilkleiggqslnldcreynadka
ivdsgttllrlpqkvfdavveavaraslipafsdgfwtgsqlacwtnsetpwsyfpkisi
ylrdenssrsfritilpqlyiqpmmgaglnyecyrfgispstnalvigatvmegfyvifd
raqkrvgfaaspcaeiagaavseisgpfstedvasncvpa

    Sequence, based on observed residues (ATOM records):
    >6uj0A (A:)
amvdnlqgrgyylemligtppqklqilvdtgssnfavagtphsyidtyfdtersstyrsk
gfdvtvkytqgswtgfvgedlvtipkgfntsflvniatifesenfflpgikwngilglay
atlakpsssletffdslvtqanipnvfsmqmcgaglpvanggslvlggiepslykgdiwy
tpikeewyyqieilkleiggqslnldcreynadkaivdsgttllrlpqkvfdavveavar
aslipafsdgfwtgsqlacwsetpwsyfpkisiylrdenssrsfritilpqlyiqpmmye
cyrfgispstnalvigatvmegfyvifdraqkrvgfaaspcaeiagaavseisgpfsted
vasncvp

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6uj0B (B:)
mgalaralllpllaqwllraapelapapftlplrvaaatnrvvaptpgpgtpaerhadgl
alalepalaspagaanflamvdnlqgdsgrgyylemligtppqklqilvdtgssnfavag
tphsyidtyfdtersstyrskgfdvtvkytqgswtgfvgedlvtipkgfntsflvniati
fesenfflpgikwngilglayatlakpsssletffdslvtqanipnvfsmqmcgaglpva
gsgtnggslvlggiepslykgdiwytpikeewyyqieilkleiggqslnldcreynadka
ivdsgttllrlpqkvfdavveavaraslipafsdgfwtgsqlacwtnsetpwsyfpkisi
ylrdenssrsfritilpqlyiqpmmgaglnyecyrfgispstnalvigatvmegfyvifd
raqkrvgfaaspcaeiagaavseisgpfstedvasncvpa

    Sequence, based on observed residues (ATOM records):
    >6uj0B (B:)
lamvdnlqgrgyylemligtppqklqilvdtgssnfavagtphsyidtyfdtersstyrs
kgfdvtvkytqgswtgfvgedlvtipkgfntsflvniatifesenfflpgikwngilgla
yatlakpsssletffdslvtqanipnvfsmqmcgaglpvggslvlggiepslykgdiwyt
pikeewyyqieilkleiggqslnldcreynadkaivdsgttllrlpqkvfdavveavara
slipafsdgfwtgsqlacwtnsetpwsyfpkisiylrdenssrsfritilpqlyiqpmny
ecyrfgispstnalvigatvmegfyvifdraqkrvgfaaspcaeiagaavseisgpfstv
asncvpa

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records:
    >6uj0C (C:)
xxxxxxx

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6uj0D (D:)
xxxxxxx

    Sequence, based on observed residues (ATOM records):
    >6uj0D (D:)
xxxxx