PDB entry 6uez

View 6uez on RCSB PDB site
Description: Human sterol 14a-demethylase (CYP51) in complex with the substrate lanosterol
Class: oxidoreductase
Keywords: monooxygenase, sterol biosynthesis, cytochrome P450, substrate-induced conformational change, OXIDOREDUCTASE
Deposited on 2019-09-23, released 2020-06-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-24.
Experiment type: XRAY
Resolution: 1.98 Å
R-factor: N/A
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Lanosterol 14-alpha demethylase
    Species: Homo sapiens [TaxId:9606]
    Gene: CYP51A1, CYP51
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16850 (11-End)
      • expression tag (7-10)
      • engineered mutation (181)
      • engineered mutation (264)
    Domains in SCOPe 2.08: d6ueza1, d6ueza2
  • Chain 'B':
    Compound: Lanosterol 14-alpha demethylase
    Species: Homo sapiens [TaxId:9606]
    Gene: CYP51A1, CYP51
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16850 (11-End)
      • expression tag (8-10)
      • engineered mutation (181)
      • engineered mutation (264)
    Domains in SCOPe 2.08: d6uezb1, d6uezb2
  • Heterogens: LAN, HEM, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6uezA (A:)
    makktsskgklppyifspipflghaiafgkspieflenayekygpvfsftmvgktftyll
    gsdaaallfnsknedlnaedvysrlttpvfgkgvaydvpnpvfleqkkmlksglniahfk
    qhvsiieketkeyfeswgesgeknvfealseliiltashclhgkeirsqlnekvaqlyad
    laggfshaawllpgwlplpsfrrrdrahreikdifykaiqkrrqsqekiddilqtlldat
    ykdgrpltddevagmliglllagqatssttsawmgfflardktlqkkcyleqktvcgenl
    ppltydqlkdlnlldrciketlrlrppimimmrmartpqtvagytippghqvcvsptvnq
    rlkdswverldfnpdrylqdnpasgekfayvpfgagrhrcigenfayvqiktiwstmlrl
    yefdlidgyfptvnyttmihtpenpvirykrrsk
    

    Sequence, based on observed residues (ATOM records): (download)
    >6uezA (A:)
    kgklppyifspipflghaiafgkspieflenayekygpvfsftmvgktftyllgsdaaal
    lfnsknedlnaedvysrlttpvfgkgvaydvpnpvfleqkkmlksglniahfkqhvsiie
    ketkeyfeswgesgeknvfealseliiltashclhgkeirsqlnekvaqlyadlaggfsh
    aawllpgwlplpsfrrrdrahreikdifykaiqkrrqsqekiddilqtlldatykdgrpl
    tddevagmliglllagqatssttsawmgfflardktlqkkcyleqktvcgenlppltydq
    lkdlnlldrciketlrlrppimimmrmartpqtvagytippghqvcvsptvnqrlkdswv
    erldfnpdrylqdnpasgekfayvpfgagrhrcigenfayvqiktiwstmlrlyefdlid
    gyfptvnyttmihtpenpvirykrrs
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >6uezB (B:)
    makktsskgklppyifspipflghaiafgkspieflenayekygpvfsftmvgktftyll
    gsdaaallfnsknedlnaedvysrlttpvfgkgvaydvpnpvfleqkkmlksglniahfk
    qhvsiieketkeyfeswgesgeknvfealseliiltashclhgkeirsqlnekvaqlyad
    laggfshaawllpgwlplpsfrrrdrahreikdifykaiqkrrqsqekiddilqtlldat
    ykdgrpltddevagmliglllagqatssttsawmgfflardktlqkkcyleqktvcgenl
    ppltydqlkdlnlldrciketlrlrppimimmrmartpqtvagytippghqvcvsptvnq
    rlkdswverldfnpdrylqdnpasgekfayvpfgagrhrcigenfayvqiktiwstmlrl
    yefdlidgyfptvnyttmihtpenpvirykrrsk
    

    Sequence, based on observed residues (ATOM records): (download)
    >6uezB (B:)
    gklppyifspipflghaiafgkspieflenayekygpvfsftmvgktftyllgsdaaall
    fnsknedlnaedvysrlttpvfgkgvaydvpnpvfleqkkmlksglniahfkqhvsiiek
    etkeyfeswgesgeknvfealseliiltashclhgkeirsqlnekvaqlyadlaggfsha
    awllpgwlplpsfrrrdrahreikdifykaiqkrrqsqekiddilqtlldatykdgrplt
    ddevagmliglllagqatssttsawmgfflardktlqkkcyleqktvcgenlppltydql
    kdlnlldrciketlrlrppimimmrmartpqtvagytippghqvcvsptvnqrlkdswve
    rldfnpdrylqdnpasgekfayvpfgagrhrcigenfayvqiktiwstmlrlyefdlidg
    yfptvnyttmihtpenpvirykrrs