PDB entry 6ud5

View 6ud5 on RCSB PDB site
Description: crystal structure of human tryptophan 2,3-dioxygenase in complex with carbon monoxide and tryptophan
Deposited on 2019-09-18, released 2021-02-03
The last revision was dated 2021-02-17, with a file datestamp of 2021-02-12.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: N/A
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tryptophan 2,3-dioxygenase
    Species: Homo sapiens [TaxId:9606]
    Gene: TDO2, TDO
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Tryptophan 2,3-dioxygenase
    Species: Homo sapiens [TaxId:9606]
    Gene: TDO2, TDO
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Tryptophan 2,3-dioxygenase
    Species: Homo sapiens [TaxId:9606]
    Gene: TDO2, TDO
    Database cross-references and differences (RAF-indexed):
    • Uniprot P48775 (Start-372)
      • expression tag (373-374)
  • Chain 'D':
    Compound: Tryptophan 2,3-dioxygenase
    Species: Homo sapiens [TaxId:9606]
    Gene: TDO2, TDO
    Database cross-references and differences (RAF-indexed):
    • Uniprot P48775 (Start-372)
      • expression tag (373-374)
  • Heterogens: TRP, HEM, CMO, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6ud5A (A:)
mlpvegseedksqtgvnraskggliygnylhlekvlnaqelqsetkgnkihdehlfiith
qayelwfkqilweldsvreifqnghvrdernmlkvvsrmhrvsvilkllvqqfsiletmt
aldfndfreylspasgfqslqfrllenkigvlqnmrvpynrrhyrdnfkgeenelllkse
qektllelveawlertpglephgfnfwgkleknitrgleeefiriqakeeseekeeqvae
fqkqkevllslfdekrhehllskgerrlsyralqgalmiyfyreeprfqvpfqlltslmd
idslmtkwrynhvcmvhrmlgskagtggssgyhylrstvsdrykvfvdlfnlstyliprh
wipkmnptihkflehhhhhh

    Sequence, based on observed residues (ATOM records):
    >6ud5A (A:)
gliygnylhlekvlnaqelqsetkgnkihdehlfiithqayelwfkqilweldsvreifq
nghvrdernmlkvvsrmhrvsvilkllvqqfsiletmtaldfndfreylspasgfqslqf
rllenkigvlqnmrvpynrrhyrdnfkgeenelllkseqektllelveawlertpgleph
gfnfwgkleknitrgleeefiriqakeeseekeeqvaefqkqkevllslfdekrhehlls
kgerrlsyralqgalmiyfyreeprfqvpfqlltslmdidslmtkwrynhvcmvhrmlgs
kagtggssgyhylrstvsdrykvfvdlfnlstyliprhwipkmnptihkfl

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6ud5B (B:)
mlpvegseedksqtgvnraskggliygnylhlekvlnaqelqsetkgnkihdehlfiith
qayelwfkqilweldsvreifqnghvrdernmlkvvsrmhrvsvilkllvqqfsiletmt
aldfndfreylspasgfqslqfrllenkigvlqnmrvpynrrhyrdnfkgeenelllkse
qektllelveawlertpglephgfnfwgkleknitrgleeefiriqakeeseekeeqvae
fqkqkevllslfdekrhehllskgerrlsyralqgalmiyfyreeprfqvpfqlltslmd
idslmtkwrynhvcmvhrmlgskagtggssgyhylrstvsdrykvfvdlfnlstyliprh
wipkmnptihkflehhhhhh

    Sequence, based on observed residues (ATOM records):
    >6ud5B (B:)
gliygnylhlekvlnaqelqsetkgnkihdehlfiithqayelwfkqilweldsvreifq
nghvrdernmlkvvsrmhrvsvilkllvqqfsiletmtaldfndfreylspasgfqslqf
rllenkigvlqnmrvpyyrdnfkgeenelllkseqektllelveawlertpglephgfnf
wgkleknitrgleeefiriqakeeseekeeqvaefqkqkevllslfdekrhehllskger
rlsyralqgalmiyfyreeprfqvpfqlltslmdidslmtkwrynhvcmvhrmlgskagt
ggssgyhylrstvsdrykvfvdlfnlstyliprhwipkmnptihkfl

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6ud5C (C:)
mlpvegseedksqtgvnraskggliygnylhlekvlnaqelqsetkgnkihdehlfiith
qayelwfkqilweldsvreifqnghvrdernmlkvvsrmhrvsvilkllvqqfsiletmt
aldfndfreylspasgfqslqfrllenkigvlqnmrvpynrrhyrdnfkgeenelllkse
qektllelveawlertpglephgfnfwgkleknitrgleeefiriqakeeseekeeqvae
fqkqkevllslfdekrhehllskgerrlsyralqgalmiyfyreeprfqvpfqlltslmd
idslmtkwrynhvcmvhrmlgskagtggssgyhylrstvsdrykvfvdlfnlstyliprh
wipkmnptihkflehhhhhh

    Sequence, based on observed residues (ATOM records):
    >6ud5C (C:)
gliygnylhlekvlnaqelqsetkgnkihdehlfiithqayelwfkqilweldsvreifq
nghvrdernmlkvvsrmhrvsvilkllvqqfsiletmtaldfndfreylspasgfqslqf
rllenkigvlqnmrvpyrdnfkgeenelllkseqektllelveawlertpglephgfnfw
gkleknitrgleeefiriqaekeeqvaefqkqkevllslfdekrhehllskgerrlsyra
lqgalmiyfyreeprfqvpfqlltslmdidslmtkwrynhvcmvhrmlgskagtggssgy
hylrstvsdrykvfvdlfnlstyliprhwipkmnptihkfleh

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6ud5D (D:)
mlpvegseedksqtgvnraskggliygnylhlekvlnaqelqsetkgnkihdehlfiith
qayelwfkqilweldsvreifqnghvrdernmlkvvsrmhrvsvilkllvqqfsiletmt
aldfndfreylspasgfqslqfrllenkigvlqnmrvpynrrhyrdnfkgeenelllkse
qektllelveawlertpglephgfnfwgkleknitrgleeefiriqakeeseekeeqvae
fqkqkevllslfdekrhehllskgerrlsyralqgalmiyfyreeprfqvpfqlltslmd
idslmtkwrynhvcmvhrmlgskagtggssgyhylrstvsdrykvfvdlfnlstyliprh
wipkmnptihkflehhhhhh

    Sequence, based on observed residues (ATOM records):
    >6ud5D (D:)
gliygnylhlekvlnaqelqsetkgnkihdehlfiithqayelwfkqilweldsvreifq
nghvrdernmlkvvsrmhrvsvilkllvqqfsiletmtaldfndfreylspasgfqslqf
rllenkigvlqnmrvpynrrhyrdnfkgeenelllkseqektllelveawlertpgleph
gfnfwgkleknitrgleeefiriqakeeseekeeqvaefqkqkevllslfdekrhehlls
kgerrlsyralqgalmiyfyreeprfqvpfqlltslmdidslmtkwrynhvcmvhrmlgs
kagtggssgyhylrstvsdrykvfvdlfnlstyliprhwipkmnptihkfleh