PDB entry 6u9s

View 6u9s on RCSB PDB site
Description: Crystal structure of human CD81 large extracellular loop in complex with 5A6 Fab
Class: cell adhesion
Keywords: tetraspanin, antibody, CELL ADHESION
Deposited on 2019-09-09, released 2020-05-13
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-05-13, with a file datestamp of 2020-05-08.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 5A6 FAB Heavy Chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6U9S (0-End)
    Domains in SCOPe 2.08: d6u9sa_
  • Chain 'B':
    Compound: 5A6 FAB Light Chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6U9S (0-218)
    Domains in SCOPe 2.08: d6u9sb1, d6u9sb2
  • Chain 'C':
    Compound: CD81 antigen
    Species: Homo sapiens [TaxId:9606]
    Gene: CD81, TAPA1, TSPAN28
    Database cross-references and differences (RAF-indexed):
    • Uniprot P60033 (2-90)
      • expression tag (1)
      • expression tag (91-92)
    Domains in SCOPe 2.08: d6u9sc1, d6u9sc2, d6u9sc3
  • Chain 'D':
    Compound: 5A6 FAB Heavy Chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6U9S (0-End)
    Domains in SCOPe 2.08: d6u9sd_
  • Chain 'E':
    Compound: 5A6 FAB Light Chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6U9S (0-End)
    Domains in SCOPe 2.08: d6u9se1, d6u9se2
  • Chain 'F':
    Compound: CD81 antigen
    Species: Homo sapiens [TaxId:9606]
    Gene: CD81, TAPA1, TSPAN28
    Database cross-references and differences (RAF-indexed):
    • Uniprot P60033 (2-90)
      • expression tag (91-93)
    Domains in SCOPe 2.08: d6u9sf1, d6u9sf2
  • Heterogens: GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6u9sA (A:)
qvqlvqsgselkkpgasvkvsckasgytftddsihwvrqapgqglewmgwintetgepty
addfkgrfvfsldtsvstaylqisslkaedtavyycarlspvvvifiywgqgtlvtvssa
stkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssg
lyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscggsglevlfq

    Sequence, based on observed residues (ATOM records): (download) 
    >6u9sA (A:)
qvqlvqsgselkkpgasvkvsckasgytftddsihwvrqapgqglewmgwintetgepty
addfkgrfvfsldtsvstaylqisslkaedtavyycarlspvvvifiywgqgtlvtvssa
stkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssg
lyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepks

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6u9sB (B:)
divmtqsplslpvtpgepasisckssqsllhsrtrknylawylqkpgqspqlliywastr
esgvpdrfsgsgsgtdftlkisrveaedvgvyyckqsynlyafgqgtkleikrtvaapsv
fifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl
sstltlskadyekhkvyacevthqglsspvtksfnrgec

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6u9sC (C:)
etgfvnkdqiakdvkqfydqalqqavvdddannakavvktfhetldccgsstltalttsv
lknnlcpsgsniisnlfkedchqkiddlfsgshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6u9sC (C:)
tgfvnkdqiakdvkqfydqalqqavvdddannakavvktfhetldccgsstltalttsvl
knnlcpsgsniisnlfkedchqkiddlfsgsh

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6u9sD (D:)
qvqlvqsgselkkpgasvkvsckasgytftddsihwvrqapgqglewmgwintetgepty
addfkgrfvfsldtsvstaylqisslkaedtavyycarlspvvvifiywgqgtlvtvssa
stkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssg
lyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscggsglevlfq

    Sequence, based on observed residues (ATOM records): (download) 
    >6u9sD (D:)
qvqlvqsgselkkpgasvkvsckasgytftddsihwvrqapgqglewmgwintetgepty
addfkgrfvfsldtsvstaylqisslkaedtavyycarlspvvvifiywgqgtlvtvssa
stkgpsvfplapssstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgl
yslssvvtvpssslgtqtyicnvnhkpsntkvdkkvep

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6u9sE (E:)
divmtqsplslpvtpgepasisckssqsllhsrtrknylawylqkpgqspqlliywastr
esgvpdrfsgsgsgtdftlkisrveaedvgvyyckqsynlyafgqgtkleikrtvaapsv
fifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl
sstltlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >6u9sE (E:)
divmtqsplslpvtpgepasisckssqsllhsrtrknylawylqkpgqspqlliywastr
esgvpdrfsgsgsgtdftlkisrveaedvgvyyckqsynlyafgqgtkleikrtvaapsv
fifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl
sstltlskadyekhkvyacevthqglsspvtksfnrge

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6u9sF (F:)
etgfvnkdqiakdvkqfydqalqqavvdddannakavvktfhetldccgsstltalttsv
lknnlcpsgsniisnlfkedchqkiddlfsgshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6u9sF (F:)
gfvnkdqiakdvkqfydqalqqavvdddannakavvktfhetldccgsstltalttsvlk
nnlcpsgsniisnlfkedchqkiddlfsgshh