PDB entry 6u8g

View 6u8g on RCSB PDB site
Description: brd4-bd2 in complex with the cyclic peptide 3.1_2_ack7toa
Deposited on 2019-09-05, released 2020-08-19
The last revision was dated 2021-03-03, with a file datestamp of 2021-02-26.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bromodomain-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD4, HUNK1
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Bromodomain-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD4, HUNK1
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Bromodomain-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD4, HUNK1
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Bromodomain-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD4, HUNK1
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: cyclic peptide 3.1_2_AcK7toA
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 6U8G
  • Chain 'F':
    Compound: cyclic peptide 3.1_2_AcK7toA
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 6U8G
  • Heterogens: ALY, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6u8gA (A:)
qgplgsstnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlp
dyykiiktpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealek
lflqkinelpteepefpgrlerphrd

    Sequence, based on observed residues (ATOM records):
    >6u8gA (A:)
stnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykii
ktpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqki
nelpte

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6u8gB (B:)
qgplgsstnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlp
dyykiiktpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealek
lflqkinelpteepefpgrlerphrd

    Sequence, based on observed residues (ATOM records):
    >6u8gB (B:)
stnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykii
ktpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqki
nelpte

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6u8gC (C:)
qgplgsstnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlp
dyykiiktpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealek
lflqkinelpteepefpgrlerphrd

    Sequence, based on observed residues (ATOM records):
    >6u8gC (C:)
tnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykiiktpmdmgtikkrlennyy
wnaqeciqdfntmftncyiynkpgddivlmaealeklflqkinelpte

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6u8gD (D:)
qgplgsstnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlp
dyykiiktpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealek
lflqkinelpteepefpgrlerphrd

    Sequence, based on observed residues (ATOM records):
    >6u8gD (D:)
nqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykiiktpmdmgtikkrlennyyw
naqeciqdfntmftncyiynkpgddivlmaealeklflqkinelpte

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records:
    >6u8gE (E:)
wktikgatwrtkqc

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records:
    >6u8gF (F:)
wktikgatwrtkqc