PDB entry 6u7c

View 6u7c on RCSB PDB site
Description: Human GRK2 in complex with Gbetagamma subunits and CCG258747
Class: transferase/signaling protein
Keywords: G-protein coupled receptor kinase, kinase inhibitor, SIGNALING PROTEIN, TRANSFERASE-SIGNALING PROTEIN complex
Deposited on 2019-09-02, released 2020-04-15
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-04-15, with a file datestamp of 2020-04-10.
Experiment type: XRAY
Resolution: 2.44 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-adrenergic receptor kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: GRK2, ADRBK1, BARK, BARK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6u7ca1, d6u7ca2, d6u7ca3
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Bos taurus [TaxId:9913]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6u7cb_
  • Chain 'G':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Bos taurus [TaxId:9913]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6u7cg_
  • Heterogens: Q1Y, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6u7cA (A:)
madleavladvsylmamekskatpaaraskkillpepsirsvmqkyledrgevtfekifs
qklgyllfrdfclnhleearplvefyeeikkyekleteeervarsreifdsyimkellac
shpfsksatehvqghlgkkqvppdlfqpyieeicqnlrgdvfqkfiesdkftrfcqwknv
elnihltmndfsvhriigrggfgevygcrkadtgkmyamkcldkkrikmkqgetlalner
imlslvstgdcpfivcmsyafhtpdklsfildlmnggdlhyhlsqhgvfseadmrfyaae
iilglehmhnrfvvyrdlkpanilldehghvrisdlglacdfskkkphasvgthgymape
vlqkgvaydssadwfslgcmlfkllrghspfrqhktkdkheidrmtltmavelpdsfspe
lrsllegllqrdvnrrlgclgrgaqevkespffrsldwqmvflqkyppplipprgevnaa
dafdigsfdeedtkgiklldsdqelyrnfpltiserwqqevaetvfdtinaetdrleark
kaknkqlgheedyalgkdcimhgymskmgnpfltqwqrryfylfpnrlewrgegeapqsl
ltmeeiqsveetqikerkclllkirggkqfilqcdsdpelvqwkkelrdayreaqqlvqr
vpkmknkprspvvelskvplvqrgsangl

    Sequence, based on observed residues (ATOM records): (download) 
    >6u7cA (A:)
kkillpepsirsvmqkyledrgevtfekifsqklgyllfrdfclnhleearplvefyeei
kkyekleteeervarsreifdsyimkellacshpfsksatehvqghlgkkqvppdlfqpy
ieeicqnlrgdvfqkfiesdkftrfcqwknvelnihltmndfsvhriigrggfgevygcr
kadtgkmyamkcldkkrikmkqgetlalnerimlslvstgdcpfivcmsyafhtpdklsf
ildlmnggdlhyhlsqhgvfseadmrfyaaeiilglehmhnrfvvyrdlkpanilldehg
hvrisdlglacdfskkkphasvgthgymapevlqkgvaydssadwfslgcmlfkllrghs
pfrqhktkdkheidrmtltmavelpdsfspelrsllegllqrdvnrrlgclgrgaqevke
spffrsldwqmvflqkyppplipprgevnaadafdigtkgiklldsdqelyrnfpltise
rwqqevaetvfdtinaetdrlearkkaknkqlgdyalgkdcimhgymskmgnpfltqwqr
ryfylfpnrlewrgegeapqslltmeeiqsveetqikerkclllkirggkqfilqcdsdp
elvqwkkelrdayreaqqlvqrvpkmknkpr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6u7cB (B:)
mseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiya
mhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldni
csiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttf
tghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngna
fatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdal
kadragvlaghdnrvsclgvtddgmavatgswdsflkiwn

    Sequence, based on observed residues (ATOM records): (download) 
    >6u7cB (B:)
seldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyam
hwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnic
siynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttft
ghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnaf
atgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalk
adragvlaghdnrvsclgvtddgmavatgswdsflkiwn

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >6u7cG (G:)
masnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenp
frekkffsail

    Sequence, based on observed residues (ATOM records): (download) 
    >6u7cG (G:)
asiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfrek