PDB entry 6u6w

View 6u6w on RCSB PDB site
Description: Discovery and optimization of salicyclic acid-derived sulfonamide inhibitors of the WDR5:MYC protein-protein interaction
Class: transcription/inhibitor
Keywords: WDR5, MYC, RBBP5, structure-based design, high-throughput screening, TRANSCRIPTION-INHIBITOR complex
Deposited on 2019-08-30, released 2019-12-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-01-08, with a file datestamp of 2020-01-03.
Experiment type: XRAY
Resolution: 1.2 Å
R-factor: N/A
AEROSPACI score: 0.64 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: WD repeat-containing protein 5
    Species: Homo sapiens [TaxId:9606]
    Gene: WDR5, BIG3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6u6wa_
  • Chain 'B':
    Compound: WD repeat-containing protein 5
    Species: Homo sapiens [TaxId:9606]
    Gene: WDR5, BIG3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6u6wb_
  • Heterogens: Q0Y, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6u6wA (A:)
tqskptpvkpnyalkftlaghtkavssvkfspngewlasssadklikiwgaydgkfekti
sghklgisdvawssdsnllvsasddktlkiwdvssgkclktlkghsnyvfccnfnpqsnl
ivsgsfdesvriwdvktgkclktlpahsdpvsavhfnrdgslivsssydglcriwdtasg
qclktlidddnppvsfvkfspngkyilaatldntlklwdyskgkclktytghknekycif
anfsvtggkwivsgsednlvyiwnlqtkeivqklqghtdvvistachpteniiasaalen
dktiklwksdc

    Sequence, based on observed residues (ATOM records): (download) 
    >6u6wA (A:)
tqskptpvkpnyalkftlaghtkavssvkfspngewlasssadklikiwgaydgkfekti
sghklgisdvawssdsnllvsasddktlkiwdvssgkclktlkghsnyvfccnfnpqsnl
ivsgsfdesvriwdvktgkclktlpahsdpvsavhfnrdgslivsssydglcriwdtasg
qclktlidnppvsfvkfspngkyilaatldntlklwdyskgkclktytghknekycifan
fsvtggkwivsgsednlvyiwnlqtkeivqklqghtdvvistachpteniiasaalendk
tiklwksdc

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6u6wB (B:)
tqskptpvkpnyalkftlaghtkavssvkfspngewlasssadklikiwgaydgkfekti
sghklgisdvawssdsnllvsasddktlkiwdvssgkclktlkghsnyvfccnfnpqsnl
ivsgsfdesvriwdvktgkclktlpahsdpvsavhfnrdgslivsssydglcriwdtasg
qclktlidddnppvsfvkfspngkyilaatldntlklwdyskgkclktytghknekycif
anfsvtggkwivsgsednlvyiwnlqtkeivqklqghtdvvistachpteniiasaalen
dktiklwksdc

    Sequence, based on observed residues (ATOM records): (download) 
    >6u6wB (B:)
tqskptpvkpnyalkftlaghtkavssvkfspngewlasssadklikiwgaydgkfekti
sghklgisdvawssdsnllvsasddktlkiwdvssgkclktlkghsnyvfccnfnpqsnl
ivsgsfdesvriwdvktgkclktlpahsdpvsavhfnrdgslivsssydglcriwdtasg
qclktlnppvsfvkfspngkyilaatldntlklwdyskgkclktytghknekycifanfs
vtggkwivsgsednlvyiwnlqtkeivqklqghtdvvistachpteniiasaalendkti
klwksdc