PDB entry 6u6i

View 6u6i on RCSB PDB site
Description: NTD of GluA2 in complex with CNIH3 - with antagonist ZK200775 - in asymmetric global conformation
Class: transport protein
Keywords: ionotropic glutamate receptor, AMPA receptor, cornichon, auxiliary subunit, ion channel, ligand gated ion channel, synaptic transmission, excitatory synaptic transmission, neurotransmitter receptor, stargazin, TARP, ZK200775, lipid, MPQX, TRANSPORT PROTEIN
Deposited on 2019-08-29, released 2019-12-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: EM
Resolution: 3.12 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glutamate receptor 2
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Gria2, Glur2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6u6ia_
  • Chain 'B':
    Compound: Glutamate receptor 2
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Gria2, Glur2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6u6ib_
  • Chain 'C':
    Compound: Glutamate receptor 2
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Gria2, Glur2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6u6ic_
  • Chain 'D':
    Compound: Glutamate receptor 2
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Gria2, Glur2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6u6id_
  • Heterogens: BMA, NAG

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6u6iA (A:)
mqkimhisvllspvlwglifgvssnsiqigglfprgadqeysafrvgmvqfstsefrltp
hidnlevansfavtnafcsqfsrgvyaifgfydkksvntitsfcgtlhvsfitpsfptdg
thpfviqmrpdlkgallslieyyqwdkfaylydsdrglstlqavldsaaekkwqvtainv
gninndkkdetyrslfqdlelkkerrvildcerdkvndivdqvitigkhvkgyhyiianl
gftdgdllkiqfgganvsgfqivdyddslvskfierwstleekeypgahtatikytsalt
ydavqvmteafrnlrkqrieisrrgnagdclanpavpwgqgveieralkqvqveglsgni
kfdqngkrinytinimelktngprkigywsevdkmvvtltelpsgndtsglenktvvvtt
ilespyvmmkknhemlegneryegycvdlaaeiakhcgfkykltivgdgkygardadtki
wngmvgelvygkadiaiapltitlvreevidfskpfmslgisimikkpqkskpgvfsfld
playeiwmcivfayigvsvvlflvsrfspyewhteefedgretqssestnefgifnslwf
slgafmrqgcdisprslsgrivggvwwfftliiissytanlaafltvermvspiesaedl
skqteiaygtldsgstkeffrrskiavfdkmwtymrsaepsvfvrttaegvarvrkskgk
yayllestmneyieqrkpcdtmkvggnldskgygiatpkgsslgnavnlavlklneqgll
dklknkwwydkgecgsgggdskektsalslsnvagvfyilvgglglamlvaliefcyksr
aeakrmkvaknpqninpsssqnsqnfatdykddddkegynvygiesvki

    Sequence, based on observed residues (ATOM records): (download) 
    >6u6iA (A:)
nsiqigglfprgadqeysafrvgmvqfstsefrltphidnlevansfavtnafcsqfsrg
vyaifgfydkksvntitsfcgtlhvsfitpsfptdgthpfviqmrpdlkgallslieyyq
wdkfaylydsdrglstlqavldsaaekkwqvtainvgninndkkdetyrslfqdlelkke
rrvildcerdkvndivdqvitigkhvkgyhyiianlgftdgdllkiqfgganvsgfqivd
yddslvskfierwstleekeypgahtatikytsaltydavqvmteafrnlrkqrieisrr
gnagdclanpavpwgqgveieralkqvqveglsgnikfdqngkrinytinimelktngpr
kigywsevdkmvvt

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6u6iB (B:)
mqkimhisvllspvlwglifgvssnsiqigglfprgadqeysafrvgmvqfstsefrltp
hidnlevansfavtnafcsqfsrgvyaifgfydkksvntitsfcgtlhvsfitpsfptdg
thpfviqmrpdlkgallslieyyqwdkfaylydsdrglstlqavldsaaekkwqvtainv
gninndkkdetyrslfqdlelkkerrvildcerdkvndivdqvitigkhvkgyhyiianl
gftdgdllkiqfgganvsgfqivdyddslvskfierwstleekeypgahtatikytsalt
ydavqvmteafrnlrkqrieisrrgnagdclanpavpwgqgveieralkqvqveglsgni
kfdqngkrinytinimelktngprkigywsevdkmvvtltelpsgndtsglenktvvvtt
ilespyvmmkknhemlegneryegycvdlaaeiakhcgfkykltivgdgkygardadtki
wngmvgelvygkadiaiapltitlvreevidfskpfmslgisimikkpqkskpgvfsfld
playeiwmcivfayigvsvvlflvsrfspyewhteefedgretqssestnefgifnslwf
slgafmrqgcdisprslsgrivggvwwfftliiissytanlaafltvermvspiesaedl
skqteiaygtldsgstkeffrrskiavfdkmwtymrsaepsvfvrttaegvarvrkskgk
yayllestmneyieqrkpcdtmkvggnldskgygiatpkgsslgnavnlavlklneqgll
dklknkwwydkgecgsgggdskektsalslsnvagvfyilvgglglamlvaliefcyksr
aeakrmkvaknpqninpsssqnsqnfatdykddddkegynvygiesvki

    Sequence, based on observed residues (ATOM records): (download) 
    >6u6iB (B:)
nsiqigglfprgadqeysafrvgmvqfstsefrltphidnlevansfavtnafcsqfsrg
vyaifgfydkksvntitsfcgtlhvsfitpsfptdgthpfviqmrpdlkgallslieyyq
wdkfaylydsdrglstlqavldsaaekkwqvtainvgninndkkdetyrslfqdlelkke
rrvildcerdkvndivdqvitigkhvkgyhyiianlgftdgdllkiqfgganvsgfqivd
yddslvskfierwstleekeypgahtatikytsaltydavqvmteafrnlrkqrieisrr
gnagdclanpavpwgqgveieralkqvqveglsgnikfdqngkrinytinimelktngpr
kigywsevdkmvvt

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6u6iC (C:)
mqkimhisvllspvlwglifgvssnsiqigglfprgadqeysafrvgmvqfstsefrltp
hidnlevansfavtnafcsqfsrgvyaifgfydkksvntitsfcgtlhvsfitpsfptdg
thpfviqmrpdlkgallslieyyqwdkfaylydsdrglstlqavldsaaekkwqvtainv
gninndkkdetyrslfqdlelkkerrvildcerdkvndivdqvitigkhvkgyhyiianl
gftdgdllkiqfgganvsgfqivdyddslvskfierwstleekeypgahtatikytsalt
ydavqvmteafrnlrkqrieisrrgnagdclanpavpwgqgveieralkqvqveglsgni
kfdqngkrinytinimelktngprkigywsevdkmvvtltelpsgndtsglenktvvvtt
ilespyvmmkknhemlegneryegycvdlaaeiakhcgfkykltivgdgkygardadtki
wngmvgelvygkadiaiapltitlvreevidfskpfmslgisimikkpqkskpgvfsfld
playeiwmcivfayigvsvvlflvsrfspyewhteefedgretqssestnefgifnslwf
slgafmrqgcdisprslsgrivggvwwfftliiissytanlaafltvermvspiesaedl
skqteiaygtldsgstkeffrrskiavfdkmwtymrsaepsvfvrttaegvarvrkskgk
yayllestmneyieqrkpcdtmkvggnldskgygiatpkgsslgnavnlavlklneqgll
dklknkwwydkgecgsgggdskektsalslsnvagvfyilvgglglamlvaliefcyksr
aeakrmkvaknpqninpsssqnsqnfatdykddddkegynvygiesvki

    Sequence, based on observed residues (ATOM records): (download) 
    >6u6iC (C:)
nsiqigglfprgadqeysafrvgmvqfstsefrltphidnlevansfavtnafcsqfsrg
vyaifgfydkksvntitsfcgtlhvsfitpsfptdgthpfviqmrpdlkgallslieyyq
wdkfaylydsdrglstlqavldsaaekkwqvtainvgninndkkdetyrslfqdlelkke
rrvildcerdkvndivdqvitigkhvkgyhyiianlgftdgdllkiqfgganvsgfqivd
yddslvskfierwstleekeypgahtatikytsaltydavqvmteafrnlrkqrieisrr
gnagdclanpavpwgqgveieralkqvqveglsgnikfdqngkrinytinimelktngpr
kigywsevdkmvvt

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6u6iD (D:)
mqkimhisvllspvlwglifgvssnsiqigglfprgadqeysafrvgmvqfstsefrltp
hidnlevansfavtnafcsqfsrgvyaifgfydkksvntitsfcgtlhvsfitpsfptdg
thpfviqmrpdlkgallslieyyqwdkfaylydsdrglstlqavldsaaekkwqvtainv
gninndkkdetyrslfqdlelkkerrvildcerdkvndivdqvitigkhvkgyhyiianl
gftdgdllkiqfgganvsgfqivdyddslvskfierwstleekeypgahtatikytsalt
ydavqvmteafrnlrkqrieisrrgnagdclanpavpwgqgveieralkqvqveglsgni
kfdqngkrinytinimelktngprkigywsevdkmvvtltelpsgndtsglenktvvvtt
ilespyvmmkknhemlegneryegycvdlaaeiakhcgfkykltivgdgkygardadtki
wngmvgelvygkadiaiapltitlvreevidfskpfmslgisimikkpqkskpgvfsfld
playeiwmcivfayigvsvvlflvsrfspyewhteefedgretqssestnefgifnslwf
slgafmrqgcdisprslsgrivggvwwfftliiissytanlaafltvermvspiesaedl
skqteiaygtldsgstkeffrrskiavfdkmwtymrsaepsvfvrttaegvarvrkskgk
yayllestmneyieqrkpcdtmkvggnldskgygiatpkgsslgnavnlavlklneqgll
dklknkwwydkgecgsgggdskektsalslsnvagvfyilvgglglamlvaliefcyksr
aeakrmkvaknpqninpsssqnsqnfatdykddddkegynvygiesvki

    Sequence, based on observed residues (ATOM records): (download) 
    >6u6iD (D:)
nsiqigglfprgadqeysafrvgmvqfstsefrltphidnlevansfavtnafcsqfsrg
vyaifgfydkksvntitsfcgtlhvsfitpsfptdgthpfviqmrpdlkgallslieyyq
wdkfaylydsdrglstlqavldsaaekkwqvtainvgninndkkdetyrslfqdlelkke
rrvildcerdkvndivdqvitigkhvkgyhyiianlgftdgdllkiqfgganvsgfqivd
yddslvskfierwstleekeypgahtatikytsaltydavqvmteafrnlrkqrieisrr
gnagdclanpavpwgqgveieralkqvqveglsgnikfdqngkrinytinimelktngpr
kigywsevdkmvvt