PDB entry 6u3x

View 6u3x on RCSB PDB site
Description: PCSK9 in complex with compound 2
Class: hydrolase
Keywords: Serine Type Endopeptidase Activity Proteolysis, HYDROLASE
Deposited on 2019-08-22, released 2019-11-06
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-01-29, with a file datestamp of 2020-01-24.
Experiment type: XRAY
Resolution: 2.64 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Proprotein convertase subtilisin/kexin type 9
    Species: Homo sapiens [TaxId:9606]
    Gene: PCSK9, NARC1, PSEC0052
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Proprotein convertase subtilisin/kexin type 9
    Species: Homo sapiens [TaxId:9606]
    Gene: PCSK9, NARC1, PSEC0052
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8NBP7
      • engineered mutation (443)
    Domains in SCOPe 2.08: d6u3xb1, d6u3xb2
  • Heterogens: PVV, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >6u3xB (B:)
    qededgdyeelvlalrseedglaeapehgttatfhrcakdpwrlpgtyvvvlkeethlsq
    sertarrlqaqaarrgyltkilhvfhgllpgflvkmsgdllelalklphvdyieedssvf
    aqsipwnleritppryradeyqppdggslvevylldtsiqsdhreiegrvmvtdfenvpe
    edgtrfhrqaskcdshgthlagvvsgrdagvakgasmrslrvlncqgkgtvsgtliglef
    irksqlvqpvgplvvllplaggysrvlnaacqrlaragvvlvtaagnfrddaclyspasa
    pevitvgatnaqdqpvtlgtlgtnfgrcvdlfapgediigassdcstcfvsqsgtsqaaa
    hvagiaammlsaepeltlaelrqrlihfsakdvineawfpedqrvltpnlvaalppsthg
    agwqlfcrtvwsahsgptrmataiarcapdeellscssfsrsgkrrgermeaqggklvcr
    ahnafggegvyaiarccllpqancsvhtappaeasmgtrvhchqqghvltgcsshweved
    lgthkppvlrprgqpnqcvghreasihascchapgleckvkehgipapqeqvtvaceegw
    tltgcsalpgtshvlgayavdntcvvrsrdvsttgstseeavtavaiccrsrhlaqasqe
    lqkgnsadiqhsggrsslegprfegkpipnpllgldstrtghhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >6u3xB (B:)
    sipwnleritppryrggslvevylldtsiqsdhreiegrvmvtdfenvpeedaskcdshg
    thlagvvsgrdagvakgasmrslrvlncqgkgtvsgtliglefirksqlvqpvgplvvll
    plaggysrvlnaacqrlaragvvlvtaagnfrddaclyspasapevitvgatnaqdqpvt
    lgtlgtnfgrcvdlfapgediigassdcstcfvsqsgtsqaaahvagiaammlsaepelt
    laelrqrlihfsakdvineawfpedqrvltpnlvaalppsthgwqlfcrtvwsahsgptr
    mataiarcapdeellscssfsrsgkrrgermeaqggklvcrahnafggegvyaiarccll
    pqancsvhtappaeasmgtrvhchqqghvltgcsshwevedlqpnqcvghreasihascc
    hapgleckvkehgipqeqvtvaceegwtltgcsalpshvlgayavdntcvvrsravtava
    iccrsr