PDB entry 6u3p

View 6u3p on RCSB PDB site
Description: Binary complex of native hAChE with oxime reactivator LG-703
Class: hydrolase
Keywords: reactivator complex, bis-oxime, HYDROLASE
Deposited on 2019-08-22, released 2020-02-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-04-08, with a file datestamp of 2020-04-03.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: acetylcholinesterase
    Species: Homo sapiens [TaxId:9606]
    Gene: ACHE
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6u3pa_
  • Chain 'B':
    Compound: acetylcholinesterase
    Species: Homo sapiens [TaxId:9606]
    Gene: ACHE
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6u3pb_
  • Heterogens: PQY, DMS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6u3pA (A:)
gplegredaellvtvrggrlrgirlktpggpvsaflgipfaeppmgprrflppepkqpws
gvvdattfqsvcyqyvdtlypgfegtemwnpnrelsedclylnvwtpyprptsptpvlvw
iygggfysgassldvydgrflvqaertvlvsmnyrvgafgflalpgsreapgnvglldqr
lalqwvqenvaafggdptsvtlfgesagaasvgmhllsppsrglfhravlqsgapngpwa
tvgmgearrratqlahlvgcppggtggndtelvaclrtrpaqvlvnhewhvlpqesvfrf
sfvpvvdgdflsdtpealinagdfhglqvlvgvvkdegsyflvygapgfskdneslisra
eflagvrvgvpqvsdlaaeavvlhytdwlhpedparlrealsdvvgdhnvvcpvaqlagr
laaqgarvyayvfehrastlswplwmgvphgyeiefifgipldpsrnytaeekifaqrlm
rywanfartgdpneprdpkapqwppytagaqqyvsldlrplevrrglraqacafwnrflp
kllsatdtld

    Sequence, based on observed residues (ATOM records): (download) 
    >6u3pA (A:)
edaellvtvrggrlrgirlktpggpvsaflgipfaeppmgprrflppepkqpwsgvvdat
tfqsvcyqyvdtlypgfegtemwnpnrelsedclylnvwtpyprptsptpvlvwiygggf
ysgassldvydgrflvqaertvlvsmnyrvgafgflalpgsreapgnvglldqrlalqwv
qenvaafggdptsvtlfgesagaasvgmhllsppsrglfhravlqsgapngpwatvgmge
arrratqlahlvgcppggtggndtelvaclrtrpaqvlvnhewhvlpqesvfrfsfvpvv
dgdflsdtpealinagdfhglqvlvgvvkdegsyflvygapgfskdneslisraeflagv
rvgvpqvsdlaaeavvlhytdwlhpedparlrealsdvvgdhnvvcpvaqlagrlaaqga
rvyayvfehrastlswplwmgvphgyeiefifgipldpsrnytaeekifaqrlmrywanf
artgdpneprdpkapqwppytagaqqyvsldlrplevrrglraqacafwnrflpkllsat

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6u3pB (B:)
gplegredaellvtvrggrlrgirlktpggpvsaflgipfaeppmgprrflppepkqpws
gvvdattfqsvcyqyvdtlypgfegtemwnpnrelsedclylnvwtpyprptsptpvlvw
iygggfysgassldvydgrflvqaertvlvsmnyrvgafgflalpgsreapgnvglldqr
lalqwvqenvaafggdptsvtlfgesagaasvgmhllsppsrglfhravlqsgapngpwa
tvgmgearrratqlahlvgcppggtggndtelvaclrtrpaqvlvnhewhvlpqesvfrf
sfvpvvdgdflsdtpealinagdfhglqvlvgvvkdegsyflvygapgfskdneslisra
eflagvrvgvpqvsdlaaeavvlhytdwlhpedparlrealsdvvgdhnvvcpvaqlagr
laaqgarvyayvfehrastlswplwmgvphgyeiefifgipldpsrnytaeekifaqrlm
rywanfartgdpneprdpkapqwppytagaqqyvsldlrplevrrglraqacafwnrflp
kllsatdtld

    Sequence, based on observed residues (ATOM records): (download) 
    >6u3pB (B:)
edaellvtvrggrlrgirlktpggpvsaflgipfaeppmgprrflppepkqpwsgvvdat
tfqsvcyqyvdtlypgfegtemwnpnrelsedclylnvwtpyprptsptpvlvwiygggf
ysgassldvydgrflvqaertvlvsmnyrvgafgflalpgsreapgnvglldqrlalqwv
qenvaafggdptsvtlfgesagaasvgmhllsppsrglfhravlqsgapngpwatvgmge
arrratqlahlvgcppggtggndtelvaclrtrpaqvlvnhewhvlpqesvfrfsfvpvv
dgdflsdtpealinagdfhglqvlvgvvkdegsyflvygapgfskdneslisraeflagv
rvgvpqvsdlaaeavvlhytdwlhpedparlrealsdvvgdhnvvcpvaqlagrlaaqga
rvyayvfehrastlswplwmgvphgyeiefifgipldpsrnytaeekifaqrlmrywanf
artgdpneprdpkapqwppytagaqqyvsldlrplevrrglraqacafwnrflpkllsat