PDB entry 6u3i

View 6u3i on RCSB PDB site
Description: design of organo-peptides as bipartite pcsk9 antagonists
Deposited on 2019-08-21, released 2020-02-05
The last revision was dated 2020-03-04, with a file datestamp of 2020-02-28.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Proprotein convertase subtilisin/kexin type 9
    Species: Homo sapiens [TaxId:9606]
    Gene: PCSK9, NARC1, PSEC0052
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8NBP7
      • variant (473)
  • Chain 'B':
    Compound: cis-1-amino-4-phenylcyclohexaneacyl-WNLK(hR)I(D-ser)LLR - NH2
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6U3I (0-10)
  • Chain 'H':
    Compound: 7G7 heavy chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6U3I (0-End)
  • Chain 'L':
    Compound: 7G7 light chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: CA, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6u3iA (A:)
mgtvssrrswwplplllllllllgpagaraqededgdyeelvlalrseedglaeapehgt
tatfhrcakdpwrlpgtyvvvlkeethlsqsertarrlqaqaarrgyltkilhvfhgllp
gflvkmsgdllelalklphvdyieedssvfaqsipwnleritppryradeyqppdggslv
evylldtsiqsdhreiegrvmvtdfenvpeedgtrfhrqaskcdshgthlagvvsgrdag
vakgasmrslrvlncqgkgtvsgtliglefirksqlvqpvgplvvllplaggysrvlnaa
cqrlaragvvlvtaagnfrddaclyspasapevitvgatnaqdqpvtlgtlgtnfgrcvd
lfapgediigassdcstcfvsqsgtsqaaahvagiaammlsaepeltlaelrqrlihfsa
kdvineawfpedqrvltpnlvaalppsthgagwqlfcrtvwsahsgptrmataiarcapd
eellscssfsrsgkrrgermeaqggklvcrahnafggegvyaiarccllpqancsvhtap
paeasmgtrvhchqqghvltgcsshwevedlgthkppvlrprgqpnqcvghreasihasc
chapgleckvkehgipapqeqvtvaceegwtltgcsalpgtshvlgayavdntcvvrsrd
vsttgstseeavtavaiccrsrhlaqasqelqhhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6u3iA (A:)
tatfhrcakdpwrlpgtyvvvlkeethlsqsertarrlqaqaarrgyltkilhvfhgllp
gflvkmsgdllelalklphvdyieedssvfaqgslvevylldtsiqsdhreiegrvmvtd
fenvpeedgtrfhrqaskcdshgthlagvvsgrdagvakgasmrslrvlncqgkgtvsgt
liglefirksqlvqpvgplvvllplaggysrvlnaacqrlaragvvlvtaagnfrddacl
yspasapevitvgatnaqdqpvtlgtlgtnfgrcvdlfapgediigassdcstcfvsqsg
tsqaaahvagiaammlsaepeltlaelrqrlihfsakdvineawfpedqrvltpnlvaal
ppwqlfcrtvwsahsgptrmataiarcapdeellscssfsrsgkrrgermeaqggklvcr
ahnafggegvyaiarccllpqancsvhtappaeasmgtrvhchqqghvltgcsshweved
lgthkppvlrprgqpnqcvghreasihascchapgleckvkehgipapqeqvtvaceegw
tltgcsalpgtshvlgayavdntcvvrsrdavtavaiccrsr

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records:
    >6u3iB (B:)
xwnlkrisllr

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6u3iH (H:)
qvqlkqsgaelvrpgasvklsckasgyiftdyyinwlkkrpgqglewiariypgsghtyy
nenfkdkatltaeksssnvymqlssltsedsavyfcarenfygssyvdwyfdvwgtgttv
tvssakttppsvyplapgcgdttgssvtlgclvkgyfpesvtvtwnsgslsssvhtfpal
lqsglytmsssvtvpsstwpsqtvtcsvahpassttvdkklep

    Sequence, based on observed residues (ATOM records):
    >6u3iH (H:)
qvqlkqsgaelvrpgasvklsckasgyiftdyyinwlkkrpgqglewiariypgsghtyy
nenfkdkatltaeksssnvymqlssltsedsavyfcarenfygssyvdwyfdvwgtgttv
tvssakttppsvyplapgcgdttgssvtlgclvkgyfpesvtvtwnsgslsssvhtfpal
lqsglytmsssvtvpsstwpsqtvtcsvahpassttvdkkle

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records:
    >6u3iL (L:)
divmtqsqkfmstsggdrvsitcktsqnvgtavawfqqkpgqspklliysasnrytgvsd
rftgsgsgtefiftisyaqsedladyfchqyssypltfgagtklelkradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrnec