PDB entry 6u26

View 6u26 on RCSB PDB site
Description: PCSK9 in complex with compound 16
Class: HYDROLASE/HYDROLASE Inhibitor
Keywords: CHOLESTEROL CLEARANCE, PCSK9, LDLR, Autocatalytic cleavage, Cholesterol metabolism, Disulfide bond, Glycoprotein, Hydrolase, Lipid metabolism, Phosphoprotein, Protease, Secreted, Serine protease, inhibitor, HYDROLASE-HYDROLASE Inhibitor complex
Deposited on 2019-08-19, released 2019-11-06
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-01-29, with a file datestamp of 2020-01-24.
Experiment type: XRAY
Resolution: 1.53 Å
R-factor: N/A
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Proprotein convertase subtilisin/kexin type 9
    Species: Homo sapiens [TaxId:9606]
    Gene: PCSK9, NARC1, PSEC0052
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Proprotein convertase subtilisin/kexin type 9
    Species: Homo sapiens [TaxId:9606]
    Gene: PCSK9, NARC1, PSEC0052
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8NBP7
      • engineered mutation (443)
    Domains in SCOPe 2.08: d6u26b1, d6u26b2
  • Heterogens: 063, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6u26B (B:)
qededgdyeelvlalrseedglaeapehgttatfhrcakdpwrlpgtyvvvlkeethlsq
sertarrlqaqaarrgyltkilhvfhgllpgflvkmsgdllelalklphvdyieedssvf
aqsipwnleritppryradeyqppdggslvevylldtsiqsdhreiegrvmvtdfenvpe
edgtrfhrqaskcdshgthlagvvsgrdagvakgasmrslrvlncqgkgtvsgtliglef
irksqlvqpvgplvvllplaggysrvlnaacqrlaragvvlvtaagnfrddaclyspasa
pevitvgatnaqdqpvtlgtlgtnfgrcvdlfapgediigassdcstcfvsqsgtsqaaa
hvagiaammlsaepeltlaelrqrlihfsakdvineawfpedqrvltpnlvaalppsthg
agwqlfcrtvwsahsgptrmataiarcapdeellscssfsrsgkrrgermeaqggklvcr
ahnafggegvyaiarccllpqancsvhtappaeasmgtrvhchqqghvltgcsshweved
lgthkppvlrprgqpnqcvghreasihascchapgleckvkehgipapqeqvtvaceegw
tltgcsalpgtshvlgayavdntcvvrsrdvsttgstseeavtavaiccrsrhlaqasqe
lqkgnsadiqhsggrsslegprfegkpipnpllgldstrtghhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6u26B (B:)
sipwnleritppryrslvevylldtsiqsdhreiegrvmvtdfenvpeedaskcdshgth
lagvvsgrdagvakgasmrslrvlncqgkgtvsgtliglefirksqlvqpvgplvvllpl
aggysrvlnaacqrlaragvvlvtaagnfrddaclyspasapevitvgatnaqdqpvtlg
tlgtnfgrcvdlfapgediigassdcstcfvsqsgtsqaaahvagiaammlsaepeltla
elrqrlihfsakdvineawfpedqrvltpnlvaalppsthgagwqlfcrtvwsahsgptr
mataiarcapdeellscssfsrsgkrrgermeaqggklvcrahnafggegvyaiarccll
pqancsvhtappatrvhchqqghvltgcsshwevedqpnqcvghreasihascchapgle
ckvkehgipeqvtvaceegwtltgcsalpshvlgayavdntcvvrsravtavaiccrsr