PDB entry 6u1n

View 6u1n on RCSB PDB site
Description: gpcr-beta arrestin structure in lipid bilayer
Deposited on 2019-08-16, released 2020-02-26
The last revision was dated 2020-03-25, with a file datestamp of 2020-03-20.
Experiment type: EM
Resolution: 4 Å
R-factor: N/A
AEROSPACI score: 0.03 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'C':
    Compound: beta-arrestin-1
    Species: Rattus norvegicus [TaxId:10116]
    Gene: ARRB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P29066
      • engineered mutation (66)
      • engineered mutation (132)
      • engineered mutation (147)
      • engineered mutation (157)
      • engineered mutation (249)
      • engineered mutation (258)
      • engineered mutation (276)
  • Chain 'H':
    Compound: Fab30 heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6U1N (Start-111)
    • Uniprot V9HW68 (112-End)
  • Chain 'L':
    Compound: Fab30 light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6U1N (0-104)
    • Uniprot Q7Z3Y4 (105-End)
  • Chain 'R':
    Compound: Muscarinic acetylcholine receptor M2, Vasopressin V2 receptor chimera
    Species: Homo sapiens [TaxId:9606]
    Gene: AVPR2, ADHR, DIR, DIR3, V2R
    Database cross-references and differences (RAF-indexed):
  • Heterogens: 2CU

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6u1nC (C:)
gspefpgrlgdkgtrvfkkaspngkltvylgkrdfvdhidlvdpvdgvvlvdpeylkerr
vyvtltvafrygredldvlgltfrkdlfvanvqsfppapedkkpltrlqerlikklgeha
ypftfeippnlpssvtlqpgpedtgkalgvdyevkafvaenleekihkrnsvrlvirkvq
yaperpgpqptaettrqflmsdkplhleasldkeiyyhgepisvnvhvtnntnktvkkik
isvrqyadivlfntaqykvpvameeaddtvapsstfskvytltpflannrekrglaldgk
lkhedtnlasstllreganreilgiivsykvkvklvvsrggllgdlassdvavelpftlm
hpkpkeepphrevpesetpvdtnlieldtndddivfedfar

    Sequence, based on observed residues (ATOM records):
    >6u1nC (C:)
trvfkkaspngkltvylgkrdfvdhidlvdpvdgvvlvdpeylkerrvyvtltvafrygr
edldvlgltfrkdlfvanvqsfppapedkkpltrlqerlikklgehaypftfeippnlps
svtlqpgpedtgkalgvdyevkafvaenleekihkrnsvrlvirkvqyaperpgpqptae
ttrqflmsdkplhleasldkeiyyhgepisvnvhvtnntnktvkkikisvrqyadivlfn
taqykvpvameeaddtvapsstfskvytltpflannrekrglaldgklkhedtnlasstl
lreganreilgiivsykvkvklvvsrggllgdlassdvavelpftlmhpkpkeepphre

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6u1nH (H:)
eisevqlvesggglvqpggslrlscaasgfnvysssihwvrqapgkglewvasissyygy
tyyadsvkgrftisadtskntaylqmnslraedtavyycarsrqfwysgldywgqgtlvt
vssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavl
qssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkthhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6u1nH (H:)
vqlvesggglvqpggslrlscaasgfnvysssihwvrqapgkglewvasissyygytyya
dsvkgrftisadtskntaylqmnslraedtavyycarsrqfwysgldywgqgtlvtvss

  • Chain 'L':
    Sequence, based on SEQRES records:
    >6u1nL (L:)
sdiqmtqspsslsasvgdrvtitcrasqsvssavawyqqkpgkapklliysasslysgvp
srfsgsrsgtdftltisslqpedfatyycqqykyvpvtfgqgtkveikrtvaapsvfifp
psdsqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records):
    >6u1nL (L:)
sdiqmtqspsslsasvgdrvtitcrasqsvssavawyqqkpgkapklliysasslysgvp
srfsgsrsgtdftltisslqpedfatyycqqykyvpvtfgqgtkveik

  • Chain 'R':
    Sequence, based on SEQRES records:
    >6u1nR (R:)
dykddddknnstnssnnslaltspyktfevvfivlvagslslvtiignilvmvsikvnrh
lqtvnnyflfslacadliigvfsmnlytlytvigywplgpvvcdlwlaldyvvsnasvmn
lliisfdryfcvtkpltypvkrttkmagmmiaaawvlsfilwapailfwqfivgvrtved
gecyiqffsnaavtfgtaiaafylpviimtvlywhisrasksrikkdkkepvanqdpvsp
slvqgrivkpnnnnmpssddglehnkiqngkaprdpvtencvqgeekessndstsvsava
snmrddeitqdentvstslghskdenskqtcirigtktpksdsctptnttvevvgssgqn
gdekqnivarkivkmtkqpakkkpppsrekkvtrtilaillafiitwapynvmvlintfc
apcipntvwtigywlcyinstinpacyalcnatfkktfkhllmchyknigatrlpetggg
argrtppslgpqdescttassslakdtss

    Sequence, based on observed residues (ATOM records):
    >6u1nR (R:)
tfevvfivlvagslslvtiignilvmvsikvnrhlqtvnnyflfslacadliigvfsmnl
ytlytvigywplgpvvcdlwlaldyvvsnasvmnlliisfdryfcvtkpltypvkrttkm
agmmiaaawvlsfilwapailfwqfivgvrtvedgecyiqffsnaavtfgtaiaafylpv
iimtvlywhisrasekkvtrtilaillafiitwapynvmvlintfcapcipntvwtigyw
lcyinstinpacyalcnatfkktfkescttassslakd