PDB entry 6u06

View 6u06 on RCSB PDB site
Description: Discovery of Lysine-Targeted eIF4E Inhibitors through Covalent Docking
Class: translation
Keywords: cap-binding site, anti-neoplastic, inhibitor, translation initiation blocking, TRANSLATION, TRANSLATION-INHIBITOR complex
Deposited on 2019-08-13, released 2019-10-16
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-03-25, with a file datestamp of 2020-03-20.
Experiment type: XRAY
Resolution: 1.96 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: eukaryotic translation initiation factor 4e
    Species: Mus musculus [TaxId:10090]
    Gene: eif4e
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6u06a_
  • Chain 'B':
    Compound: eukaryotic translation initiation factor 4e
    Species: Mus musculus [TaxId:10090]
    Gene: eif4e
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6u06b_
  • Chain 'C':
    Compound: eukaryotic translation initiation factor 4e
    Species: Mus musculus [TaxId:10090]
    Gene: eif4e
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6u06c_
  • Chain 'D':
    Compound: eukaryotic translation initiation factor 4e
    Species: Mus musculus [TaxId:10090]
    Gene: eif4e
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6u06d_
  • Heterogens: EI8, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6u06A (A:)
vanpehyikhplqnrwalwffkndksktwqanlrliskfdtvedfwalynhiqlssnlmp
gcdyslfkdgiepmwedeknkrggrwlitlnkqqrrsdldrfwletllcligesfddysd
dvcgavvnvrakgdkiaiwttecenrdavthigrvykerlglppkivigyqshadtatks
gsttknrfvv

    Sequence, based on observed residues (ATOM records): (download) 
    >6u06A (A:)
npehyikhplqnrwalwffkndksktwqanlrliskfdtvedfwalynhiqlssnlmpgc
dyslfkdgiepmwedeknkrggrwlitlnkqqrrsdldrfwletllcligesfddysddv
cgavvnvrakgdkiaiwttecenrdavthigrvykerlglppkivigyqshadtatknrf
vv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6u06B (B:)
vanpehyikhplqnrwalwffkndksktwqanlrliskfdtvedfwalynhiqlssnlmp
gcdyslfkdgiepmwedeknkrggrwlitlnkqqrrsdldrfwletllcligesfddysd
dvcgavvnvrakgdkiaiwttecenrdavthigrvykerlglppkivigyqshadtatks
gsttknrfvv

    Sequence, based on observed residues (ATOM records): (download) 
    >6u06B (B:)
npehyikhplqnrwalwffkndksktwqanlrliskfdtvedfwalynhiqlssnlmpgc
dyslfkdgiepmwedeknkrggrwlitlnkqqrrsdldrfwletllcligesfddysddv
cgavvnvrakgdkiaiwttecenrdavthigrvykerlglppkivigyqshadtatknrf
vv

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6u06C (C:)
vanpehyikhplqnrwalwffkndksktwqanlrliskfdtvedfwalynhiqlssnlmp
gcdyslfkdgiepmwedeknkrggrwlitlnkqqrrsdldrfwletllcligesfddysd
dvcgavvnvrakgdkiaiwttecenrdavthigrvykerlglppkivigyqshadtatks
gsttknrfvv

    Sequence, based on observed residues (ATOM records): (download) 
    >6u06C (C:)
vanpehyikhplqnrwalwffkndksktwqanlrliskfdtvedfwalynhiqlssnlmp
gcdyslfkdgiepmwedeknkrggrwlitlnkqqrrsdldrfwletllcligesfddysd
dvcgavvnvrakgdkiaiwttecenrdavthigrvykerlglppkivigyqshadtknrf
vv

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6u06D (D:)
vanpehyikhplqnrwalwffkndksktwqanlrliskfdtvedfwalynhiqlssnlmp
gcdyslfkdgiepmwedeknkrggrwlitlnkqqrrsdldrfwletllcligesfddysd
dvcgavvnvrakgdkiaiwttecenrdavthigrvykerlglppkivigyqshadtatks
gsttknrfvv

    Sequence, based on observed residues (ATOM records): (download) 
    >6u06D (D:)
npehyikhplqnrwalwffkndkskwqanlrliskfdtvedfwalynhiqlssnlmpgcd
yslfkdgiepmwedeknkrggrwlitlnkqqrrsdldrfwletllcligesfddysddvc
gavvnvrakgdkiaiwttecenrdavthigrvykerlglppkivigyqshadtatkknrf
vv