PDB entry 6tzu

View 6tzu on RCSB PDB site
Description: Dihydrodipicolinate synthase (DHDPS) from C.jejuni, N84A mutant with pyruvate bound in the active site
Class: lyase
Keywords: Dihydrodipicolinate synthase, Campylobacter jejuni, Tetrameric protein, TIM barrel, Allostery, LYASE
Deposited on 2019-08-13, released 2019-12-04
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-12-04, with a file datestamp of 2019-11-29.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 4-hydroxy-tetrahydrodipicolinate synthase
    Species: Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) [TaxId:192222]
    Gene: dapA, Cj0806
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9PPB4 (Start-309)
      • engineered mutation (95)
    Domains in SCOPe 2.07: d6tzua_
  • Chain 'B':
    Compound: 4-hydroxy-tetrahydrodipicolinate synthase
    Species: Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) [TaxId:192222]
    Gene: dapA, Cj0806
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9PPB4 (12-309)
      • expression tag (6-11)
      • engineered mutation (95)
    Domains in SCOPe 2.07: d6tzub1, d6tzub2
  • Chain 'C':
    Compound: 4-hydroxy-tetrahydrodipicolinate synthase
    Species: Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) [TaxId:192222]
    Gene: dapA, Cj0806
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9PPB4 (Start-309)
      • engineered mutation (95)
    Domains in SCOPe 2.07: d6tzuc_
  • Chain 'D':
    Compound: 4-hydroxy-tetrahydrodipicolinate synthase
    Species: Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) [TaxId:192222]
    Gene: dapA, Cj0806
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9PPB4 (12-309)
      • expression tag (4-11)
      • engineered mutation (95)
    Domains in SCOPe 2.07: d6tzud1, d6tzud2
  • Chain 'E':
    Compound: 4-hydroxy-tetrahydrodipicolinate synthase
    Species: Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) [TaxId:192222]
    Gene: dapA, Cj0806
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9PPB4 (Start-309)
      • engineered mutation (95)
    Domains in SCOPe 2.07: d6tzue_
  • Chain 'F':
    Compound: 4-hydroxy-tetrahydrodipicolinate synthase
    Species: Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) [TaxId:192222]
    Gene: dapA, Cj0806
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9PPB4 (Start-309)
      • engineered mutation (95)
    Domains in SCOPe 2.07: d6tzuf_
  • Heterogens: MG, EDO, ACT, PGE, PEG, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6tzuA (A:)
mrgshhhhhhgsmdkniiigamtalitpfkngkvdeqsyarlikrqiengidavvpvgtt
gesatltheehrtcieiavetckgtkvkvlagagsaatheavglakfakehgadgilsva
pyynkptqqglyehykaiaqsvdipvllynvpgrtgceistdtiiklfrdceniygvkea
sgnidkcvdllaheprmmlisgedainypilsnggkgvisvtsnllpdmisalthfalde
nykeakkindelyninkilfcesnpipiktamylaglieslefrlplcspskenfakiee
vmkkykikgf

    Sequence, based on observed residues (ATOM records): (download) 
    >6tzuA (A:)
kniiigamtalitpfkngkvdeqsyarlikrqiengidavvpvgttgesatltheehrtc
ieiavetckgtkvkvlagagsaatheavglakfakehgadgilsvapyynkptqqglyeh
ykaiaqsvdipvllynvpgrtgceistdtiiklfrdceniygvkeasgnidkcvdllahe
prmmlisgedainypilsnggkgvisvtsnllpdmisalthfaldenykeakkindelyn
inkilfcesnpipiktamylaglieslefrlplcspskenfakieevmkkykikgf

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6tzuB (B:)
mrgshhhhhhgsmdkniiigamtalitpfkngkvdeqsyarlikrqiengidavvpvgtt
gesatltheehrtcieiavetckgtkvkvlagagsaatheavglakfakehgadgilsva
pyynkptqqglyehykaiaqsvdipvllynvpgrtgceistdtiiklfrdceniygvkea
sgnidkcvdllaheprmmlisgedainypilsnggkgvisvtsnllpdmisalthfalde
nykeakkindelyninkilfcesnpipiktamylaglieslefrlplcspskenfakiee
vmkkykikgf

    Sequence, based on observed residues (ATOM records): (download) 
    >6tzuB (B:)
hhhhgsmdkniiigamtalitpfkngkvdeqsyarlikrqiengidavvpvgttgesatl
theehrtcieiavetckgtkvkvlagagsaatheavglakfakehgadgilsvapyynkp
tqqglyehykaiaqsvdipvllynvpgrtgceistdtiiklfrdceniygvkeasgnidk
cvdllaheprmmlisgedainypilsnggkgvisvtsnllpdmisalthfaldenykeak
kindelyninkilfcesnpipiktamylaglieslefrlplcspskenfakieevmkkyk
ikgf

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6tzuC (C:)
mrgshhhhhhgsmdkniiigamtalitpfkngkvdeqsyarlikrqiengidavvpvgtt
gesatltheehrtcieiavetckgtkvkvlagagsaatheavglakfakehgadgilsva
pyynkptqqglyehykaiaqsvdipvllynvpgrtgceistdtiiklfrdceniygvkea
sgnidkcvdllaheprmmlisgedainypilsnggkgvisvtsnllpdmisalthfalde
nykeakkindelyninkilfcesnpipiktamylaglieslefrlplcspskenfakiee
vmkkykikgf

    Sequence, based on observed residues (ATOM records): (download) 
    >6tzuC (C:)
kniiigamtalitpfkngkvdeqsyarlikrqiengidavvpvgttgesatltheehrtc
ieiavetckgtkvkvlagagsaatheavglakfakehgadgilsvapyynkptqqglyeh
ykaiaqsvdipvllynvpgrtgceistdtiiklfrdceniygvkeasgnidkcvdllahe
prmmlisgedainypilsnggkgvisvtsnllpdmisalthfaldenykeakkindelyn
inkilfcesnpipiktamylaglieslefrlplcspskenfakieevmkkykikgf

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6tzuD (D:)
mrgshhhhhhgsmdkniiigamtalitpfkngkvdeqsyarlikrqiengidavvpvgtt
gesatltheehrtcieiavetckgtkvkvlagagsaatheavglakfakehgadgilsva
pyynkptqqglyehykaiaqsvdipvllynvpgrtgceistdtiiklfrdceniygvkea
sgnidkcvdllaheprmmlisgedainypilsnggkgvisvtsnllpdmisalthfalde
nykeakkindelyninkilfcesnpipiktamylaglieslefrlplcspskenfakiee
vmkkykikgf

    Sequence, based on observed residues (ATOM records): (download) 
    >6tzuD (D:)
hhhhhhgsmdkniiigamtalitpfkngkvdeqsyarlikrqiengidavvpvgttgesa
tltheehrtcieiavetckgtkvkvlagagsaatheavglakfakehgadgilsvapyyn
kptqqglyehykaiaqsvdipvllynvpgrtgceistdtiiklfrdceniygvkeasgni
dkcvdllaheprmmlisgedainypilsnggkgvisvtsnllpdmisalthfaldenyke
akkindelyninkilfcesnpipiktamylaglieslefrlplcspskenfakieevmkk
ykikgf

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6tzuE (E:)
mrgshhhhhhgsmdkniiigamtalitpfkngkvdeqsyarlikrqiengidavvpvgtt
gesatltheehrtcieiavetckgtkvkvlagagsaatheavglakfakehgadgilsva
pyynkptqqglyehykaiaqsvdipvllynvpgrtgceistdtiiklfrdceniygvkea
sgnidkcvdllaheprmmlisgedainypilsnggkgvisvtsnllpdmisalthfalde
nykeakkindelyninkilfcesnpipiktamylaglieslefrlplcspskenfakiee
vmkkykikgf

    Sequence, based on observed residues (ATOM records): (download) 
    >6tzuE (E:)
dkniiigamtalitpfkngkvdeqsyarlikrqiengidavvpvgttgesatltheehrt
cieiavetckgtkvkvlagagsaatheavglakfakehgadgilsvapyynkptqqglye
hykaiaqsvdipvllynvpgrtgceistdtiiklfrdceniygvkeasgnidkcvdllah
eprmmlisgedainypilsnggkgvisvtsnllpdmisalthfaldenykeakkindely
ninkilfcesnpipiktamylaglieslefrlplcspskenfakieevmkkykikgf

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6tzuF (F:)
mrgshhhhhhgsmdkniiigamtalitpfkngkvdeqsyarlikrqiengidavvpvgtt
gesatltheehrtcieiavetckgtkvkvlagagsaatheavglakfakehgadgilsva
pyynkptqqglyehykaiaqsvdipvllynvpgrtgceistdtiiklfrdceniygvxea
sgnidkcvdllaheprmmlisgedainypilsnggkgvisvtsnllpdmisalthfalde
nykeakkindelyninkilfcesnpipiktamylaglieslefrlplcspskenfakiee
vmkkykikgf

    Sequence, based on observed residues (ATOM records): (download) 
    >6tzuF (F:)
kniiigamtalitpfkngkvdeqsyarlikrqiengidavvpvgttgesatltheehrtc
ieiavetckgtkvkvlagagsaatheavglakfakehgadgilsvapyynkptqqglyeh
ykaiaqsvdipvllynvpgrtgceistdtiiklfrdceniygvxeasgnidkcvdllahe
prmmlisgedainypilsnggkgvisvtsnllpdmisalthfaldenykeakkindelyn
inkilfcesnpipiktamylaglieslefrlplcspskenfakieevmkkykikgf