PDB entry 6tyg

View 6tyg on RCSB PDB site
Description: crystal structure of mtb sigma l transcription initiation complex with 9 nt long rna primer
Deposited on 2019-08-08, released 2020-03-11
The last revision was dated 2020-03-25, with a file datestamp of 2020-03-20.
Experiment type: XRAY
Resolution: 3.5 Å
R-factor: N/A
AEROSPACI score: 0.09 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: DNA-directed RNA polymerase subunit alpha
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: rpoA
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: DNA-directed RNA polymerase subunit alpha
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: rpoA
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: DNA-directed RNA polymerase subunit beta
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: rpoB
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: DNA-directed RNA polymerase subunit beta'
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: rpoC, rpoC_1, rpoC_2, DKC2_0716, ERS007665_00591, ERS023446_00410, ERS031537_00289, ERS124361_01694, EUB02_01475, EUB03_00860, EUB11_05575, SAMEA2682835_07420, SAMEA2682864_01702
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: DNA-directed RNA polymerase subunit omega
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: rpoZ, DKC2_1480, DSI35_24025, ERS007657_03145, ERS007661_02963, ERS007663_02972, ERS007665_03743, ERS007670_03615, ERS007679_02942, ERS007681_04445, ERS007722_03066, ERS007741_03196, ERS023446_03677, ERS024213_01369, ERS024276_01577, ERS027644_00478, ERS027646_01439, ERS027651_03169, ERS027653_00843, ERS027659_01429, ERS027661_02200, ERS027666_04715, ERS031537_03443, EU767_08910, EU768_15085, EU769_05250, EU770_14555, EU771_05130, EU773_14340, EU774_06465, EU775_07590, EU776_17830, EU777_06800, EUB02_12495, EUB03_09550, EUB06_03645, EUB07_12165, EUB08_05285, EUB09_00425, EUB10_04215, EUB11_10790, EUB13_01060, EUB14_01055, EUB16_00425, SAMEA2682864_01599, SAMEA2683035_01133
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: RNA polymerase sigma factor
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: sigL, sigX, DKC2_0784, DSI35_13315, ERS007657_01744, ERS007661_01946, ERS007670_03245, ERS007672_04865, ERS007688_03724, ERS007722_03570, ERS007731_02151, ERS007741_04102, ERS023446_03871, ERS024213_03781, ERS027644_01708, ERS027646_03649, ERS027651_00554, ERS027654_02031, ERS027659_03608, ERS027661_02428, ERS027666_03497, ERS031537_01383, ERS124361_02832, EU767_20440, EU768_17405, EU769_19535, EU770_10565, EU771_18640, EU773_15915, EU774_01235, EU775_01235, EU776_08285, EU777_18775, EUB02_13395, EUB03_01225, EUB07_01225, EUB08_01615, EUB09_12390, EUB10_16580, EUB11_05940, EUB12_18145, EUB13_14065, EUB14_03980, EUB16_03020, SAMEA2682835_06130, SAMEA2682864_01771, SAMEA2683035_02456
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: DNA (5'-d(*gp*cp*ap*tp*cp*cp*gp*tp*gp*ap*ap*tp*cp*gp*ap*gp*gp*gp*tp*g)-3')
    Species: MYCOBACTERIUM TUBERCULOSIS, synthetic [TaxId:1773]
  • Chain 'H':
    Compound: DNA (5'-d(p*gp*tp*gp*tp*cp*ap*gp*tp*ap*gp*cp*tp*gp*tp*cp*ap*cp*gp*gp*ap*tp*gp*c)-3')
    Species: MYCOBACTERIUM TUBERCULOSIS, synthetic [TaxId:1773]
  • Chain 'I':
    Compound: RNA (5'-r(p*cp*ap*cp*cp*cp*up*cp*gp*a)-3')
    Species: MYCOBACTERIUM TUBERCULOSIS, synthetic [TaxId:1773]

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6tygA (A:)
mlisqrptlsedvltdnrsqfvieplepgfgytlgnslrrtllssipgaavtsiridgvl
hefttvpgvkedvteiilnlkslvvsseedepvtmylrkqgpgevtagdivppagvtvhn
pgmhiatlndkgklevelvvergrgyvpavqnrasgaeigripvdsiyspvlkvtykvda
trveqrtdfdklildvetknsisprdalasagktlvelfglarelnveaegieigpspae
adhiasfalpiddldltvrsynclkregvhtvgelvartesdlldirnfgqksidevkik
lhqlglslkdsppsfdpsevagydvatgtwstegaydeqdyaeteql

    Sequence, based on observed residues (ATOM records):
    >6tygA (A:)
lisqrptlsedvltdnrsqfvieplepgfgytlgnslrrtllssipgaavtsiridgvlh
efttvpgvkedvteiilnlkslvvsseedepvtmylrkqgpgevtagdivppagvtvhnp
gmhiatlndkgklevelvvergrgyvpavqnrasgaeigripvdsiyspvlkvtykvdat
rveqrtdfdklildvetknsisprdalasagktlvelfglareln

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6tygB (B:)
mlisqrptlsedvltdnrsqfvieplepgfgytlgnslrrtllssipgaavtsiridgvl
hefttvpgvkedvteiilnlkslvvsseedepvtmylrkqgpgevtagdivppagvtvhn
pgmhiatlndkgklevelvvergrgyvpavqnrasgaeigripvdsiyspvlkvtykvda
trveqrtdfdklildvetknsisprdalasagktlvelfglarelnveaegieigpspae
adhiasfalpiddldltvrsynclkregvhtvgelvartesdlldirnfgqksidevkik
lhqlglslkdsppsfdpsevagydvatgtwstegaydeqdyaeteql

    Sequence, based on observed residues (ATOM records):
    >6tygB (B:)
mlisqrptlsedvltdnrsqfvieplepgfgytlgnslrrtllssipgaavtsiridgvl
hefttvpgvkedvteiilnlkslvvsseedepvtmylrkqgpgevtagdivppagvtvhn
pgmhiatlndkgklevelvvergrgyvpavqnrasgaeigripvdsiyspvlkvtykvda
trveqrtdfdklildvetknsisprdalasagktlvelfglarelnveaegi

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6tygC (C:)
mlegciladsrqsktaaspspsrpqsssnnsvpgapnrvsfaklreplevpglldvqtds
fewligsprwresaaergdvnpvggleevlyelspiedfsgsmslsfsdprfddvkapvd
eckdkdmtyaaplfvtaefinnntgeiksqtvfmgdfpmmtekgtfiingtervvvsqlv
rspgvyfdetidkstdktlhsvkvipsrgawlefdvdkrdtvgvridrkrrqpvtvllka
lgwtseqiverfgfseimrstlekdntvgtdealldiyrklrpgepptkesaqtllenlf
fkekrydlarvgrykvnkklglhvgepitsstlteedvvatieylvrlhegqttmtvpgg
vevpvetddidhfgnrrlrtvgeliqnqirvgmsrmervvrermttqdveaitpqtlini
rpvvaaikeffgtsqlsqfmdqnnplsglthkrrlsalgpgglsreraglevrdvhpshy
grmcpietpegpnigligslsvyarvnpfgfietpyrkvvdgvvsdeivyltadeedrhv
vaqanspidadgrfveprvlvrrkageveyvpssevdymdvsprqmvsvatamipflehd
danralmganmqrqavplvrseaplvgtgmelraaidagdvvvaeesgvieevsadyitv
mhdngtrrtyrmrkfarsnhgtcanqcpivdagdrveagqviadgpctddgemalgknll
vaimpweghnyedaiilsnrlveedvltsihieeheidardtklgaeeitrdipnisdev
ladldergivrigaevrdgdilvgkvtpkgeteltpeerllraifgekarevrdtslkvp
hgesgkvigirvfsrededelpagvnelvrvyvaqkrkisdgdklagrhgnkgvigkilp
vedmpfladgtpvdiilnthgvprrmnigqilethlgwcahsgwkvdaakgvpdwaarlp
delleaqpnaivstpvfdgaqeaelqgllsctlpnrdgdvlvdadgkamlfdgrsgepfp
ypvtvgymyimklhhlvddkiharstgpysmitqqplggkaqfggqrfgemecwamqayg
aaytlqelltiksddtvgrvkvyeaivkgenipepgipesfkvllkelqslclnvevlss
dgaaielregededleraaanlginlsrnesasvedla

    Sequence, based on observed residues (ATOM records):
    >6tygC (C:)
snnsvpgapnrvsfaklreplevpglldvqtdsfewligsprwresaaergdvnpvggle
evlyelspiedfsgsmslsfsdprfddvkapvdeckdkdmtyaaplfvtaefinnntgei
ksqtvfmgdfpmmtekgtfiingtervvvsqlvrspgvyfdetidkstdktlhsvkvips
rgawlefdvdkrdtvgvridrkrrqpvtvllkalgwtseqiverfgfseimrstlekdnt
vgtdealldiyrklrpgepptkesaqtllenlffkekrydlarvgrykvnkklglhvgep
itsstlteedvvatieylvrlhegqttmtvpggvevpvetddidhfgnrrlrtvgeliqn
qirvgmsrmervvrermttqdveaitpqtlinirpvvaaikeffgtsqlsqfmdqnnpls
glthkrrlsalgpgglsreraglevrdvhpshygrmcpietpegpnigligslsvyarvn
pfgfietpyrkvvdgvvsdeivyltadeedrhvvaqanspidadgrfveprvlvrrkage
veyvpssevdymdvsprqmvsvatamipflehddanralmganmqrqavplvrseaplvg
tgmelraaidagdvvvaeesgvieevsadyitvmhdngtrrtyrmrkfarsnhgtcanqc
pivdagdrveagqviadgpctddgemalgknllvaimpweghnyedaiilsnrlveedvl
tsihieeheidardtklgaeeitrdipnisdevladldergivrigaevrdgdilvgkvt
pkgeteltpeerllraifevrdtslkvphgesgkvigirvfsrededelpagvnelvrvy
vaqkrkisdgdklagrhgnkgvigkilpvedmpfladgtpvdiilnthgvprrmnigqil
ethlgwcahsgwkvdaakgvpdwaarlpdelleaqpnaivstpvfdgaqeaelqgllsct
lpnrdgdvlvdadgkamlfdgrsgepfpypvtvgymyimklhhlvddkiharstgpysmi
tqqplggkaqfggqrfgemecwamqaygaaytlqelltiksddtvgrvkvyeaivkgeni
pepgipesfkvllkelqslclnvevlssdgaaie

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6tygD (D:)
mldvnffdelriglataedirqwsygevkkpetinyrtlkpekdglfcekifgptrdwec
ycgkykrvrfkgiicercgvevtrakvrrermghielaapvthiwyfkgvpsrlgylldl
apkdlekiiyfaayvitsvdeemrhnelstleaemaverkavedqrdgelearaqklead
laeleaegakadarrkvrdggeremrqirdraqreldrlediwstftklapkqlivdenl
yrelvdrygeyftgamgaesiqklienfdidaeaeslrdvirngkgqkklralkrlkvva
afqqsgnspmgmvldavpvippelrpmvqldggrfatsdlndlyrrvinrnnrlkrlidl
gapeiivnnekrmlqesvdalfdngrrgrpvtgpgnrplkslsdllkgkqgrfrqnllgk
rvdysgrsvivvgpqlklhqcglpklmalelfkpfvmkrlvdlnhaqniksakrmverqr
pqvwdvleeviaehpvllnraptlhrlgiqafepmlvegkaiqlhplvceafnadfdgdq
mavhlplsaeaqaearilmlssnnilspasgrplamprldmvtglyylttevpgdtgeyq
pasgdhpetgvysspaeaimaadrgvlsvrakikvrltqlrppveieaelfghsgwqpgd
awmaettlgrvmfnellplgypfvnkqmhkkvqaaiindlaerypmivvaqtvdklkdag
fywatrsgvtvsmadvlvpprkkeildhyeeradkvekqfqrgalnhdernealveiwke
atdevgqalrehypddnpiitivdsgatgnftqtrtlagmkglvtnpkgefiprpvkssf
regltvleyfinthgarkgladtalrtadsgyltrrlvdvsqdvivrehdcqtergivve
laerapdgtlirdpyietsayartlgtdavdeagnvivergqdlgdpeidallaagitqv
kvrsvltcatstgvcatcygrsmatgklvdigeavgivaaqsigepgtqltmrtfhqggv
geditgglprvqelfearvprgkapiadvtgrvrledgerfykitivpddggeevvydki
skrqrlrvfkhedgservlsdgdhvevgqqlmegsadphevlrvqgprevqihlvrevqe
vyraqgvsihdkhievivrqmlrrvtiidsgsteflpgslidraefeaenrrvvaeggep
aagrpvlmgitkaslatdswlsaasfqettrvltdaaincrsdklnglkenviigklipa
gtginryrniavqpteearaaaytipsyedqyyspdfgaatgaavplddygysdyr

    Sequence, based on observed residues (ATOM records):
    >6tygD (D:)
ffdelriglataedirqwsygevkkpetinyrtlkpekdglfcekifgptrdwecycgky
krvrfkgiicercgvevtrakvrrermghielaapvthiwyfkgvpsrlgylldlapkdl
ekiiyfaayvitsvdeemrhnelstleaemaverkavedqrdgelearaqkleadlaele
aegakadarrkvrdggeremrqirdraqreldrlediwstftklapkqlivdenlyrelv
drygeyftgamgaesiqklienfdidaeaeslrdvirngkgqkklralkrlkvvaafqqs
gnspmgmvldavpvippelrpmvqldggrfatsdlndlyrrvinrnnrlkrlidlgapei
ivnnekrmlqesvdalfdngrrgrpvtgpgnrplkslsdllkgkqgrfrqnllgkrvdys
grsvivvgpqlklhqcglpklmalelfkpfvmkrlvdlnhaqniksakrmverqrpqvwd
vleeviaehpvllnraptlhrlgiqafepmlvegkaiqlhplvceafnadfdgdqmavhl
plsaeaqaearilmlssnnilspasgrplamprldmvtglyylttevpgdtgeyqpasgd
hpetgvysspaeaimaadrgvlsvrakikvrltqlrppveieaelfghsgwqpgdawmae
ttlgrvmfnellplgypfvnkqmhkkvqaaiindlaerypmivvaqtvdklkdagfywat
rsgvtvsmadvlvpprkkeildhyeeradkvekqfqrgalnhdernealveiwkeatdev
gqalrehypddnpiitivdsgatgnftqtrtlagmkglvtnpkgefiprpvkssfreglt
vleyfinthgarkgladtalrtadsgyltrrlvdvsqdvivrehdcqtergivvelaera
pdgtlirdpyietsayartlgtdavdeagnvivergqdlgdpeidallaagitqvkvrsv
ltcatstgvcatcygrsmatgklvdigeavgivaaqsigepgtqltgglprvqelfearv
prgkapiadvtgrvrledgerfykitivpddggeevvydkiskrqrlrvfkhedgservl
sdgdhvevgqqlmegsadphevlrvqgprevqihlvrevqevyraqgvsihdkhievivr
qmlrrvtiidsgsteflpgslidraefeaenrrvvaeggepaagrpvlmgitkaslatds
wlsaasfqettrvltdaaincrsdklnglkenviigklipagtginryrniavqpteear
aa

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6tygE (E:)
msisqsdaslaavpavdqfdpssgasggydtplgitnppidelldrvsskyalviyaakr
arqindyynqlgegileyvgplvepglqekplsialreihadllehtege

    Sequence, based on observed residues (ATOM records):
    >6tygE (E:)
gydtplgitnppidelldrvsskyalviyaakrarqindyynqlgegileyvgplvepgl
qekplsialreihadllehte

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6tygF (F:)
marvsgaaaaeaalmralydehaavlwryalrltgdaaqaedvvqetllrawqhpevigd
tarparawlftvarnmiiderrsarfrnvvgstdqsgtpeqstpdevnaaldrlliadal
aqlsaehraviqrsyyrgwstaqiatdlgiaegtvksrlhyavralrltlqelgvtr

    Sequence, based on observed residues (ATOM records):
    >6tygF (F:)
vsgaaaaeaalmralydehaavlwryalrltgdaaqaedvvqetllrawqhpevigdtar
parawlftvarnmiiderrsarqstpdevnaaldrlliadalaqlsaehraviqriatdl
giaegtvksrlhyavralrltlqelgv

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    No sequence available.

  • Chain 'I':
    No sequence available.