PDB entry 6txw

View 6txw on RCSB PDB site
Description: V30G Transthyretin structure in complex with Tolcalpone
Class: transport protein
Keywords: Drug repositioning, tolcapone, leptomeningeal amyloidosis, Transport protein
Deposited on 2020-01-14, released 2020-05-13
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-01-13, with a file datestamp of 2021-01-08.
Experiment type: XRAY
Resolution: 1.15 Å
R-factor: N/A
AEROSPACI score: 0.77 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Transthyretin
    Species: Homo sapiens [TaxId:9606]
    Gene: TTR, PALB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P02766 (0-115)
      • engineered mutation (20)
    Domains in SCOPe 2.08: d6txwa_
  • Chain 'B':
    Compound: Transthyretin
    Species: Homo sapiens [TaxId:9606]
    Gene: TTR, PALB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P02766 (0-115)
      • engineered mutation (20)
    Domains in SCOPe 2.08: d6txwb_
  • Heterogens: TCW, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6txwA (A:)
cplmvkvldavrgspainvaghvfrkaaddtwepfasgktsesgelhgltteeefvegiy
kveidtksywkalgispfhehaevvftandsgprrytiaallspysysttavvtnp

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6txwB (B:)
cplmvkvldavrgspainvaghvfrkaaddtwepfasgktsesgelhgltteeefvegiy
kveidtksywkalgispfhehaevvftandsgprrytiaallspysysttavvtnp