PDB entry 6twi

View 6twi on RCSB PDB site
Description: Crystal structure of the haemagglutinin mutant (Gln226Leu, Gly228Ser) from an H10N7 seal influenza virus isolated in Germany in complex with avian receptor analogue 3'-SLN
Class: viral protein
Keywords: receptor binding, fusion of virus membrane with host plasma membrane, VIRAL PROTEIN
Deposited on 2020-01-13, released 2020-10-21
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-10-21, with a file datestamp of 2020-10-16.
Experiment type: XRAY
Resolution: 2.27 Å
R-factor: N/A
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Hemagglutinin
    Species: Influenza A virus (A/harbour seal/Germany/1/2014(H10N7)) [TaxId:1572188]
    Gene: HA
    Database cross-references and differences (RAF-indexed):
    • Uniprot A0A0A7HR51 (2-End)
      • expression tag (0-1)
      • engineered mutation (222)
    Domains in SCOPe 2.07: d6twia1, d6twia2
  • Chain 'B':
    Compound: hemagglutinin HA2
    Species: Influenza A virus (A/harbour seal/Germany/1/2014(H10N7)) [TaxId:1572188]
    Gene: HA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6twib_
  • Chain 'C':
    Compound: Hemagglutinin
    Species: Influenza A virus (A/harbour seal/Germany/1/2014(H10N7)) [TaxId:1572188]
    Gene: HA
    Database cross-references and differences (RAF-indexed):
    • Uniprot A0A0A7HR51 (2-End)
      • expression tag (0-1)
      • engineered mutation (222)
    Domains in SCOPe 2.07: d6twic1, d6twic2
  • Chain 'D':
    Compound: hemagglutinin HA2
    Species: Influenza A virus (A/harbour seal/Germany/1/2014(H10N7)) [TaxId:1572188]
    Gene: HA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6twid_
  • Chain 'E':
    Compound: Hemagglutinin
    Species: Influenza A virus (A/harbour seal/Germany/1/2014(H10N7)) [TaxId:1572188]
    Gene: HA
    Database cross-references and differences (RAF-indexed):
    • Uniprot A0A0A7HR51 (2-End)
      • expression tag (0-1)
      • engineered mutation (222)
    Domains in SCOPe 2.07: d6twie1, d6twie2
  • Chain 'F':
    Compound: hemagglutinin HA2
    Species: Influenza A virus (A/harbour seal/Germany/1/2014(H10N7)) [TaxId:1572188]
    Gene: HA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6twif_
  • Heterogens: NAG, EDO, CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6twiA (A:)
dpdkiclghhavangtivktltneqeevtnatetvestslnrlcmkgrnhkdlgnchpig
mligtpacdlhltgtwdtlierknaiaycypgatvneealrqkimesggiskintgftyg
ssinsagttkacmrnggnsfyaelkwlvsknkgqnfpqttntyrnadtaehlimwgihhp
sstqekndlygtqslsisvgsstyknnfvpvvgarpqvnglssridfhwtlvqpgdkitf
shnggliapsrvskligrglgiqseapidnsceskcfwrggsintrlpfqnlsprtvgqc
pkyvnkkslmlatgmrnvpelvqgr

    Sequence, based on observed residues (ATOM records): (download) 
    >6twiA (A:)
dpdkiclghhavangtivktltneqeevtnatetvestslnrlcmkgrnhkdlgnchpig
mligtpacdlhltgtwdtlierknaiaycypgatvneealrqkimesggiskintgftyg
ssinsagttkacmrnggnsfyaelkwlvsknkgqnfpqttntyrnadtaehlimwgihhp
sstqekndlygtqslsisvgsstyknnfvpvvgarpqvnglssridfhwtlvqpgdkitf
shnggliapsrvskligrglgiqseapidnsceskcfwrggsintrlpfqnlsprtvgqc
pkyvnkkslmlatgmrnvpe

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6twiB (B:)
glfgaiagfiengwegmvdgwygfrhqnaqgtgqaadykstqaaidqitgklnriikktn
tefesiesefseidhqignvinwtkdsitdiwtyqaellvamenqhtidmadsemlnlye
rvrkqlrqnaeedgkgcfeiyhacddscmesirnntydhsqyreeallnrlninpvk

    Sequence, based on observed residues (ATOM records): (download) 
    >6twiB (B:)
glfgaiagfiengwegmvdgwygfrhqnaqgtgqaadykstqaaidqitgklnriikktn
tefesiesefseidhqignvinwtkdsitdiwtyqaellvamenqhtidmadsemlnlye
rvrkqlrqnaeedgkgcfeiyhacddscmesirnntydhsqyreeallnrln

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6twiC (C:)
dpdkiclghhavangtivktltneqeevtnatetvestslnrlcmkgrnhkdlgnchpig
mligtpacdlhltgtwdtlierknaiaycypgatvneealrqkimesggiskintgftyg
ssinsagttkacmrnggnsfyaelkwlvsknkgqnfpqttntyrnadtaehlimwgihhp
sstqekndlygtqslsisvgsstyknnfvpvvgarpqvnglssridfhwtlvqpgdkitf
shnggliapsrvskligrglgiqseapidnsceskcfwrggsintrlpfqnlsprtvgqc
pkyvnkkslmlatgmrnvpelvqgr

    Sequence, based on observed residues (ATOM records): (download) 
    >6twiC (C:)
dpdkiclghhavangtivktltneqeevtnatetvestslnrlcmkgrnhkdlgnchpig
mligtpacdlhltgtwdtlierknaiaycypgatvneealrqkimesggiskintgftyg
ssinsagttkacmrnggnsfyaelkwlvsknkgqnfpqttntyrnadtaehlimwgihhp
sstqekndlygtqslsisvgsstyknnfvpvvgarpqvnglssridfhwtlvqpgdkitf
shnggliapsrvskligrglgiqseapidnsceskcfwrggsintrlpfqnlsprtvgqc
pkyvnkkslmlatgmrnvpe

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6twiD (D:)
glfgaiagfiengwegmvdgwygfrhqnaqgtgqaadykstqaaidqitgklnriikktn
tefesiesefseidhqignvinwtkdsitdiwtyqaellvamenqhtidmadsemlnlye
rvrkqlrqnaeedgkgcfeiyhacddscmesirnntydhsqyreeallnrlninpvk

    Sequence, based on observed residues (ATOM records): (download) 
    >6twiD (D:)
glfgaiagfiengwegmvdgwygfrhqnaqgtgqaadykstqaaidqitgklnriikktn
tefesiesefseidhqignvinwtkdsitdiwtyqaellvamenqhtidmadsemlnlye
rvrkqlrqnaeedgkgcfeiyhacddscmesirnntydhsqyreeallnrln

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6twiE (E:)
dpdkiclghhavangtivktltneqeevtnatetvestslnrlcmkgrnhkdlgnchpig
mligtpacdlhltgtwdtlierknaiaycypgatvneealrqkimesggiskintgftyg
ssinsagttkacmrnggnsfyaelkwlvsknkgqnfpqttntyrnadtaehlimwgihhp
sstqekndlygtqslsisvgsstyknnfvpvvgarpqvnglssridfhwtlvqpgdkitf
shnggliapsrvskligrglgiqseapidnsceskcfwrggsintrlpfqnlsprtvgqc
pkyvnkkslmlatgmrnvpelvqgr

    Sequence, based on observed residues (ATOM records): (download) 
    >6twiE (E:)
dpdkiclghhavangtivktltneqeevtnatetvestslnrlcmkgrnhkdlgnchpig
mligtpacdlhltgtwdtlierknaiaycypgatvneealrqkimesggiskintgftyg
ssinsagttkacmrnggnsfyaelkwlvsknkgqnfpqttntyrnadtaehlimwgihhp
sstqekndlygtqslsisvgsstyknnfvpvvgarpqvnglssridfhwtlvqpgdkitf
shnggliapsrvskligrglgiqseapidnsceskcfwrggsintrlpfqnlsprtvgqc
pkyvnkkslmlatgmrnvpelvq

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6twiF (F:)
glfgaiagfiengwegmvdgwygfrhqnaqgtgqaadykstqaaidqitgklnriikktn
tefesiesefseidhqignvinwtkdsitdiwtyqaellvamenqhtidmadsemlnlye
rvrkqlrqnaeedgkgcfeiyhacddscmesirnntydhsqyreeallnrlninpvk

    Sequence, based on observed residues (ATOM records): (download) 
    >6twiF (F:)
glfgaiagfiengwegmvdgwygfrhqnaqgtgqaadykstqaaidqitgklnriikktn
tefesiesefseidhqignvinwtkdsitdiwtyqaellvamenqhtidmadsemlnlye
rvrkqlrqnaeedgkgcfeiyhacddscmesirnntydhsqyreeallnrln