PDB entry 6twh

View 6twh on RCSB PDB site
Description: Crystal structure of the haemagglutinin mutant (Gln226Leu, Gly228Ser) from an H10N7 seal influenza virus isolated in Germany
Class: viral protein
Keywords: Host Cell Surface Receptor Binding, Fusion of Virus Membrane with Host Plasma Membrane, Viral Envelope, VIRAL PROTEIN
Deposited on 2020-01-13, released 2020-10-21
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-10-21, with a file datestamp of 2020-10-16.
Experiment type: XRAY
Resolution: 2.68 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Hemagglutinin
    Species: Influenza A virus (A/harbour seal/Germany/1/2014(H10N7)) [TaxId:1572188]
    Gene: HA
    Database cross-references and differences (RAF-indexed):
    • Uniprot A0A0A7HR51 (2-End)
      • expression tag (0-1)
      • engineered mutation (222)
    Domains in SCOPe 2.07: d6twha1, d6twha2
  • Chain 'B':
    Compound: hemagglutinin HA2
    Species: Influenza A virus (A/harbour seal/Germany/1/2014(H10N7)) [TaxId:1572188]
    Gene: HA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6twhb_
  • Chain 'C':
    Compound: Hemagglutinin
    Species: Influenza A virus (A/harbour seal/Germany/1/2014(H10N7)) [TaxId:1572188]
    Gene: HA
    Database cross-references and differences (RAF-indexed):
    • Uniprot A0A0A7HR51 (2-End)
      • expression tag (0-1)
      • engineered mutation (222)
    Domains in SCOPe 2.07: d6twhc1, d6twhc2
  • Chain 'D':
    Compound: hemagglutinin HA2
    Species: Influenza A virus (A/harbour seal/Germany/1/2014(H10N7)) [TaxId:1572188]
    Gene: HA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6twhd_
  • Chain 'E':
    Compound: Hemagglutinin
    Species: Influenza A virus (A/harbour seal/Germany/1/2014(H10N7)) [TaxId:1572188]
    Gene: HA
    Database cross-references and differences (RAF-indexed):
    • Uniprot A0A0A7HR51 (2-End)
      • expression tag (0-1)
      • engineered mutation (222)
    Domains in SCOPe 2.07: d6twhe1, d6twhe2
  • Chain 'F':
    Compound: hemagglutinin HA2
    Species: Influenza A virus (A/harbour seal/Germany/1/2014(H10N7)) [TaxId:1572188]
    Gene: HA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6twhf_
  • Chain 'L':
    Compound: Hemagglutinin
    Species: Influenza A virus (A/harbour seal/Germany/1/2014(H10N7)) [TaxId:1572188]
    Gene: HA
    Database cross-references and differences (RAF-indexed):
    • Uniprot A0A0A7HR51 (2-End)
      • expression tag (0-1)
      • engineered mutation (222)
    Domains in SCOPe 2.07: d6twhl1, d6twhl2
  • Chain 'M':
    Compound: hemagglutinin HA2
    Species: Influenza A virus (A/harbour seal/Germany/1/2014(H10N7)) [TaxId:1572188]
    Gene: HA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6twhm_
  • Chain 'N':
    Compound: Hemagglutinin
    Species: Influenza A virus (A/harbour seal/Germany/1/2014(H10N7)) [TaxId:1572188]
    Gene: HA
    Database cross-references and differences (RAF-indexed):
    • Uniprot A0A0A7HR51 (2-End)
      • expression tag (0-1)
      • engineered mutation (222)
    Domains in SCOPe 2.07: d6twhn1, d6twhn2
  • Chain 'O':
    Compound: hemagglutinin HA2
    Species: Influenza A virus (A/harbour seal/Germany/1/2014(H10N7)) [TaxId:1572188]
    Gene: HA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6twho_
  • Chain 'P':
    Compound: Hemagglutinin
    Species: Influenza A virus (A/harbour seal/Germany/1/2014(H10N7)) [TaxId:1572188]
    Gene: HA
    Database cross-references and differences (RAF-indexed):
    • Uniprot A0A0A7HR51 (2-End)
      • expression tag (0-1)
      • engineered mutation (222)
    Domains in SCOPe 2.07: d6twhp1, d6twhp2
  • Chain 'Q':
    Compound: hemagglutinin HA2
    Species: Influenza A virus (A/harbour seal/Germany/1/2014(H10N7)) [TaxId:1572188]
    Gene: HA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6twhq_
  • Heterogens: NAG, CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6twhA (A:)
dpdkiclghhavangtivktltneqeevtnatetvestslnrlcmkgrnhkdlgnchpig
mligtpacdlhltgtwdtlierknaiaycypgatvneealrqkimesggiskintgftyg
ssinsagttkacmrnggnsfyaelkwlvsknkgqnfpqttntyrnadtaehlimwgihhp
sstqekndlygtqslsisvgsstyknnfvpvvgarpqvnglssridfhwtlvqpgdkitf
shnggliapsrvskligrglgiqseapidnsceskcfwrggsintrlpfqnlsprtvgqc
pkyvnkkslmlatgmrnvpelvqgr

    Sequence, based on observed residues (ATOM records): (download) 
    >6twhA (A:)
dpdkiclghhavangtivktltneqeevtnatetvestslnrlcmkgrnhkdlgnchpig
mligtpacdlhltgtwdtlierknaiaycypgatvneealrqkimesggiskintgftyg
ssinsagttkacmrnggnsfyaelkwlvsknkgqnfpqttntyrnadtaehlimwgihhp
sstqekndlygtqslsisvgsstyknnfvpvpqvnglssridfhwtlvqpgdkitfshng
gliapsrvskligrglgiqseapidnsceskcfwrggsintrlpfqnlsprtvgqcpkyv
nkkslmlatgmrnvpe

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6twhB (B:)
glfgaiagfiengwegmvdgwygfrhqnaqgtgqaadykstqaaidqitgklnriikktn
tefesiesefseidhqignvinwtkdsitdiwtyqaellvamenqhtidmadsemlnlye
rvrkqlrqnaeedgkgcfeiyhacddscmesirnntydhsqyreeallnrlninpvk

    Sequence, based on observed residues (ATOM records): (download) 
    >6twhB (B:)
glfgaiagfiengwegmvdgwygfrhqnaqgtgqaadykstqaaidqitgklnriikktn
tefesiesefseidhqignvinwtkdsitdiwtyqaellvamenqhtidmadsemlnlye
rvrkqlrqnaeedgkgcfeiyhacddscmesirnntydhsqyreeallnrln

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6twhC (C:)
dpdkiclghhavangtivktltneqeevtnatetvestslnrlcmkgrnhkdlgnchpig
mligtpacdlhltgtwdtlierknaiaycypgatvneealrqkimesggiskintgftyg
ssinsagttkacmrnggnsfyaelkwlvsknkgqnfpqttntyrnadtaehlimwgihhp
sstqekndlygtqslsisvgsstyknnfvpvvgarpqvnglssridfhwtlvqpgdkitf
shnggliapsrvskligrglgiqseapidnsceskcfwrggsintrlpfqnlsprtvgqc
pkyvnkkslmlatgmrnvpelvqgr

    Sequence, based on observed residues (ATOM records): (download) 
    >6twhC (C:)
dpdkiclghhavangtivktltneqeevtnatetvestslnrlcmkgrnhkdlgnchpig
mligtpacdlhltgtwdtlierknaiaycypgatvneealrqkimesggiskintgftyg
ssinsagttkacmrnggnsfyaelkwlvsknkgqnfpqttntyrnadtaehlimwgihhp
sstqekndlygtqslsisvgsstyknnfvpvqvnglssridfhwtlvqpgdkitfshngg
liapsrvskligrglgiqseapidnsceskcfwrggsintrlpfqnlsprtvgqcpkyvn
kkslmlatgmrnvpe

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6twhD (D:)
glfgaiagfiengwegmvdgwygfrhqnaqgtgqaadykstqaaidqitgklnriikktn
tefesiesefseidhqignvinwtkdsitdiwtyqaellvamenqhtidmadsemlnlye
rvrkqlrqnaeedgkgcfeiyhacddscmesirnntydhsqyreeallnrlninpvk

    Sequence, based on observed residues (ATOM records): (download) 
    >6twhD (D:)
glfgaiagfiengwegmvdgwygfrhqnaqgtgqaadykstqaaidqitgklnriikktn
tefesiesefseidhqignvinwtkdsitdiwtyqaellvamenqhtidmadsemlnlye
rvrkqlrqnaeedgkgcfeiyhacddscmesirnntydhsqyreeallnrln

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6twhE (E:)
dpdkiclghhavangtivktltneqeevtnatetvestslnrlcmkgrnhkdlgnchpig
mligtpacdlhltgtwdtlierknaiaycypgatvneealrqkimesggiskintgftyg
ssinsagttkacmrnggnsfyaelkwlvsknkgqnfpqttntyrnadtaehlimwgihhp
sstqekndlygtqslsisvgsstyknnfvpvvgarpqvnglssridfhwtlvqpgdkitf
shnggliapsrvskligrglgiqseapidnsceskcfwrggsintrlpfqnlsprtvgqc
pkyvnkkslmlatgmrnvpelvqgr

    Sequence, based on observed residues (ATOM records): (download) 
    >6twhE (E:)
dpdkiclghhavangtivktltneqeevtnatetvestslnrlcmkgrnhkdlgnchpig
mligtpacdlhltgtwdtlierknaiaycypgatvneealrqkimesggiskintgftyg
ssinsagttkacmrnggnsfyaelkwlvsknkgqnfpqttntyrnadtaehlimwgihhp
sstqekndlygtqslsisvgsstyknnfvpvvgarpqvnglssridfhwtlvqpgdkitf
shnggliapsrvskligrglgiqseapidnsceskcfwrggsintrlpfqnlsprtvgqc
pkyvnkkslmlatgmrnvpelv

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6twhF (F:)
glfgaiagfiengwegmvdgwygfrhqnaqgtgqaadykstqaaidqitgklnriikktn
tefesiesefseidhqignvinwtkdsitdiwtyqaellvamenqhtidmadsemlnlye
rvrkqlrqnaeedgkgcfeiyhacddscmesirnntydhsqyreeallnrlninpvk

    Sequence, based on observed residues (ATOM records): (download) 
    >6twhF (F:)
glfgaiagfiengwegmvdgwygfrhqnaqgtgqaadykstqaaidqitgklnriikktn
tefesiesefseidhqignvinwtkdsitdiwtyqaellvamenqhtidmadsemlnlye
rvrkqlrqnaeedgkgcfeiyhacddscmesirnntydhsqyreeallnrln

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >6twhL (L:)
dpdkiclghhavangtivktltneqeevtnatetvestslnrlcmkgrnhkdlgnchpig
mligtpacdlhltgtwdtlierknaiaycypgatvneealrqkimesggiskintgftyg
ssinsagttkacmrnggnsfyaelkwlvsknkgqnfpqttntyrnadtaehlimwgihhp
sstqekndlygtqslsisvgsstyknnfvpvvgarpqvnglssridfhwtlvqpgdkitf
shnggliapsrvskligrglgiqseapidnsceskcfwrggsintrlpfqnlsprtvgqc
pkyvnkkslmlatgmrnvpelvqgr

    Sequence, based on observed residues (ATOM records): (download) 
    >6twhL (L:)
dpdkiclghhavangtivktltneqeevtnatetvestslnrlcmkgrnhkdlgnchpig
mligtpacdlhltgtwdtlierknaiaycypgatvneealrqkimesggiskintgftyg
ssinsagttkacmrnggnsfyaelkwlvsknkgqnfpqttntyrnadtaehlimwgihhp
sstqekndlygtqslsisvgsstyknnfvpvvqvnglssridfhwtlvqpgdkitfshng
gliapsrvskligrglgiqseapidnsceskcfwrggsintrlpfqnlsprtvgqcpkyv
nkkslmlatgmrnvpe

  • Chain 'M':
    Sequence, based on SEQRES records: (download) 
    >6twhM (M:)
glfgaiagfiengwegmvdgwygfrhqnaqgtgqaadykstqaaidqitgklnriikktn
tefesiesefseidhqignvinwtkdsitdiwtyqaellvamenqhtidmadsemlnlye
rvrkqlrqnaeedgkgcfeiyhacddscmesirnntydhsqyreeallnrlninpvk

    Sequence, based on observed residues (ATOM records): (download) 
    >6twhM (M:)
glfgaiagfiengwegmvdgwygfrhqnaqgtgqaadykstqaaidqitgklnriikktn
tefesiesefseidhqignvinwtkdsitdiwtyqaellvamenqhtidmadsemlnlye
rvrkqlrqnaeedgkgcfeiyhacddscmesirnntydhsqyreeallnrln

  • Chain 'N':
    Sequence, based on SEQRES records: (download) 
    >6twhN (N:)
dpdkiclghhavangtivktltneqeevtnatetvestslnrlcmkgrnhkdlgnchpig
mligtpacdlhltgtwdtlierknaiaycypgatvneealrqkimesggiskintgftyg
ssinsagttkacmrnggnsfyaelkwlvsknkgqnfpqttntyrnadtaehlimwgihhp
sstqekndlygtqslsisvgsstyknnfvpvvgarpqvnglssridfhwtlvqpgdkitf
shnggliapsrvskligrglgiqseapidnsceskcfwrggsintrlpfqnlsprtvgqc
pkyvnkkslmlatgmrnvpelvqgr

    Sequence, based on observed residues (ATOM records): (download) 
    >6twhN (N:)
dpdkiclghhavangtivktltneqeevtnatetvestslnrlcmkgrnhkdlgnchpig
mligtpacdlhltgtwdtlierknaiaycypgatvneealrqkimesggiskintgftyg
ssinsagttkacmrnggnsfyaelkwlvsknkgqnfpqttntyrnadtaehlimwgihhp
sstqekndlygtqslsisvgsstyknnfvpvvgarpqvnglssridfhwtlvqpgdkitf
shnggliapsrvskligrglgiqseapidnsceskcfwrggsintrlpfqnlsprtvgqc
pkyvnkkslmlatgmrnvpe

  • Chain 'O':
    Sequence, based on SEQRES records: (download) 
    >6twhO (O:)
glfgaiagfiengwegmvdgwygfrhqnaqgtgqaadykstqaaidqitgklnriikktn
tefesiesefseidhqignvinwtkdsitdiwtyqaellvamenqhtidmadsemlnlye
rvrkqlrqnaeedgkgcfeiyhacddscmesirnntydhsqyreeallnrlninpvk

    Sequence, based on observed residues (ATOM records): (download) 
    >6twhO (O:)
glfgaiagfiengwegmvdgwygfrhqnaqgtgqaadykstqaaidqitgklnriikktn
tefesiesefseidhqignvinwtkdsitdiwtyqaellvamenqhtidmadsemlnlye
rvrkqlrqnaeedgkgcfeiyhacddscmesirnntydhsqyreeallnrln

  • Chain 'P':
    Sequence, based on SEQRES records: (download) 
    >6twhP (P:)
dpdkiclghhavangtivktltneqeevtnatetvestslnrlcmkgrnhkdlgnchpig
mligtpacdlhltgtwdtlierknaiaycypgatvneealrqkimesggiskintgftyg
ssinsagttkacmrnggnsfyaelkwlvsknkgqnfpqttntyrnadtaehlimwgihhp
sstqekndlygtqslsisvgsstyknnfvpvvgarpqvnglssridfhwtlvqpgdkitf
shnggliapsrvskligrglgiqseapidnsceskcfwrggsintrlpfqnlsprtvgqc
pkyvnkkslmlatgmrnvpelvqgr

    Sequence, based on observed residues (ATOM records): (download) 
    >6twhP (P:)
dpdkiclghhavangtivktltneqeevtnatetvestslnrlcmkgrnhkdlgnchpig
mligtpacdlhltgtwdtlierknaiaycypgatvneealrqkimesggiskintgftyg
ssinsagttkacmrnggnsfyaelkwlvsknkgqnfpqttntyrnadtaehlimwgihhp
sstqekndlygtqslsisvgsstyknnfvpvvgarpqvnglssridfhwtlvqpgdkitf
shnggliapsrvskligrglgiqseapidnsceskcfwrggsintrlpfqnlsprtvgqc
pkyvnkkslmlatgmrnvpelv

  • Chain 'Q':
    Sequence, based on SEQRES records: (download) 
    >6twhQ (Q:)
glfgaiagfiengwegmvdgwygfrhqnaqgtgqaadykstqaaidqitgklnriikktn
tefesiesefseidhqignvinwtkdsitdiwtyqaellvamenqhtidmadsemlnlye
rvrkqlrqnaeedgkgcfeiyhacddscmesirnntydhsqyreeallnrlninpvk

    Sequence, based on observed residues (ATOM records): (download) 
    >6twhQ (Q:)
glfgaiagfiengwegmvdgwygfrhqnaqgtgqaadykstqaaidqitgklnriikktn
tefesiesefseidhqignvinwtkdsitdiwtyqaellvamenqhtidmadsemlnlye
rvrkqlrqnaeedgkgcfeiyhacddscmesirnntydhsqyreeallnrln