PDB entry 6tvn

View 6tvn on RCSB PDB site
Description: Crystal Structure of 5-bromoindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase
Class: transferase
Keywords: BTK, Covalent fragments, surface entrophy reduction, crystal engineering, TRANSFERASE
Deposited on 2020-01-10, released 2020-11-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-11-25, with a file datestamp of 2020-11-20.
Experiment type: XRAY
Resolution: 2.31 Å
R-factor: N/A
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase BTK
    Species: Homo sapiens [TaxId:9606]
    Gene: BTK, AGMX1, ATK, BPK
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q06187 (0-End)
      • engineered mutation (143)
    Domains in SCOPe 2.08: d6tvna_
  • Chain 'B':
    Compound: Tyrosine-protein kinase BTK
    Species: Homo sapiens [TaxId:9606]
    Gene: BTK, AGMX1, ATK, BPK
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q06187 (0-End)
      • engineered mutation (143)
    Domains in SCOPe 2.08: d6tvnb_
  • Chain 'C':
    Compound: Tyrosine-protein kinase BTK
    Species: Homo sapiens [TaxId:9606]
    Gene: BTK, AGMX1, ATK, BPK
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q06187 (0-End)
      • engineered mutation (143)
    Domains in SCOPe 2.08: d6tvnc_
  • Chain 'D':
    Compound: Tyrosine-protein kinase BTK
    Species: Homo sapiens [TaxId:9606]
    Gene: BTK, AGMX1, ATK, BPK
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q06187 (0-End)
      • engineered mutation (143)
    Domains in SCOPe 2.08: d6tvnd_
  • Heterogens: NYQ, ZN, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6tvnA (A:)
aavilesiflkrsqqkkktsplnfkkrlflltvhklsyyeydfergrrgskkgsidveki
tcvetvvpeknppperqiprrgeessemeqisiierfpypfqvvydegplyvfspteelr
krwihqlknvirynsdlvqkyhpafwidgqylccsqtaknamgcqilen

    Sequence, based on observed residues (ATOM records): (download) 
    >6tvnA (A:)
aavilesiflkrsqqkkktsplnfkkrlflltvhklsyyeydfergrrgskkgsidveki
tcvetvvpeknppperqipemeqisiierfpypfqvvydegplyvfspteelrkrwihql
knvirynsdlvqkyhpafwidgqylccsqtaknamgcqil

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6tvnB (B:)
aavilesiflkrsqqkkktsplnfkkrlflltvhklsyyeydfergrrgskkgsidveki
tcvetvvpeknppperqiprrgeessemeqisiierfpypfqvvydegplyvfspteelr
krwihqlknvirynsdlvqkyhpafwidgqylccsqtaknamgcqilen

    Sequence, based on observed residues (ATOM records): (download) 
    >6tvnB (B:)
aavilesiflkrsqlnfkkrlflltvhklsyyeydfergrrgskkgsidvekitcvetvv
peknppperqieqisiierfpypfqvvydegplyvfspteelrkrwihqlknvirynsdl
vqkyhpafwidgqylccsqtaknamgcqil

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6tvnC (C:)
aavilesiflkrsqqkkktsplnfkkrlflltvhklsyyeydfergrrgskkgsidveki
tcvetvvpeknppperqiprrgeessemeqisiierfpypfqvvydegplyvfspteelr
krwihqlknvirynsdlvqkyhpafwidgqylccsqtaknamgcqilen

    Sequence, based on observed residues (ATOM records): (download) 
    >6tvnC (C:)
aavilesiflkrsqqkkktsplnfkkrlflltvhklsyyeydfergrrgskkgsidveki
tcvetvvpeknppperqieqisiierfpypfqvvydegplyvfspteelrkrwihqlknv
irynsdlvqkyhpafwidgqylccsqtaknamgcqil

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6tvnD (D:)
aavilesiflkrsqqkkktsplnfkkrlflltvhklsyyeydfergrrgskkgsidveki
tcvetvvpeknppperqiprrgeessemeqisiierfpypfqvvydegplyvfspteelr
krwihqlknvirynsdlvqkyhpafwidgqylccsqtaknamgcqilen

    Sequence, based on observed residues (ATOM records): (download) 
    >6tvnD (D:)
aavilesiflkrsqnfkkrlflltvhklsyyeydfergrrgskkgsidvekitcvetvvp
eknppperqieqisiierfpypfqvvydegplyvfspteelrkrwihqlknvirynsdlv
qkyhpafwidgqylccsqtaknamgcqi