PDB entry 6tuf

View 6tuf on RCSB PDB site
Description: Human Aldose Reductase in complex with ALR43
Class: oxidoreductase
Keywords: Diabetes, oxidoreductase, transient binding pocket, diabetic late effects, polyol pathway, osmotic and oxidative stress, cofactor, NADPH, NADP+, AKR1B1, ALDR1, ALR2
Deposited on 2020-01-07, released 2021-01-27
The last revision prior to the SCOPe 2.07 freeze date was dated 2021-01-27, with a file datestamp of 2021-01-22.
Experiment type: XRAY
Resolution: 1.15 Å
R-factor: N/A
AEROSPACI score: 0.78 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: aldose reductase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P15121 (0-315)
      • conflict (4)
    Domains in SCOPe 2.07: d6tufa_
  • Heterogens: NXQ, CIT, NAP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6tufA (A:)
masrillnngakmpilglgtwksppgqvteavkvaidvgyrhidcahvyqnenevgvaiq
eklreqvvkreelfivsklwctyhekglvkgacqktlsdlkldyldlylihwptgfkpgk
effpldesgnvvpsdtnildtwaameelvdeglvkaigisnfnhlqvemilnkpglkykp
avnqiechpyltqekliqycqskgivvtaysplgspdrpwakpedpslledprikaiaak
hnkttaqvlirfpmqrnlvvipksvtperiaenfkvfdfelssqdmttllsynrnwrvca
llsctshkdypfheef