PDB entry 6tu9

View 6tu9 on RCSB PDB site
Description: The ROR1 Pseudokinase Domain Bound To Ponatinib
Class: signaling protein
Keywords: Receptor Transmembrane Kinase Pseudokinase Small-molecule inhibitor, SIGNALING PROTEIN
Deposited on 2020-01-04, released 2020-01-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-08-19, with a file datestamp of 2020-08-14.
Experiment type: XRAY
Resolution: 1.94 Å
R-factor: N/A
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Inactive tyrosine-protein kinase transmembrane receptor ROR1
    Species: Homo sapiens [TaxId:9606]
    Gene: ROR1, NTRKR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q01973
      • conflict (65)
    Domains in SCOPe 2.08: d6tu9a_
  • Chain 'B':
    Compound: Inactive tyrosine-protein kinase transmembrane receptor ROR1
    Species: Homo sapiens [TaxId:9606]
    Gene: ROR1, NTRKR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q01973
      • conflict (65)
    Domains in SCOPe 2.08: d6tu9b_
  • Heterogens: 0LI, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6tu9A (A:)
msmlnaykpkskakelplsavrfmeelgecafgkiykghlylpgmdhaqlvaiktlkdyn
npqqwmefqqeaslmaelhhpnivcllgavtqeqpvcmlfeyinqgdlheflimrsphsd
vgcssdedgtvkssldhgdflhiaiqiaagmeylsshffvhkdlaarniligeqlhvkis
dlglsreiysadyyrvqsksllpirwmppeaimygkfssdsdiwsfgvvlweifsfglqp
yygfsnqeviemvrkrqllpcsedcpprmyslmtecwneipsrrprfkdihvrlrswegl
hhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6tu9A (A:)
kpkskakelplsavrfmeelgecafgkiykghlylpgmdhaqlvaiktlkdynnpqqwme
fqqeaslmaelhhpnivcllgavtqeqpvcmlfeyinqgdlheflimrsldhgdflhiai
qiaagmeylsshffvhkdlaarniligeqlhvkisdlglsreiysadyyrsllpirwmpp
eaimygkfssdsdiwsfgvvlweifsfglqpyygfsnqeviemvrkrqllpcsedcpprm
yslmtecwneipsrrprfkdihvrlrsw

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6tu9B (B:)
msmlnaykpkskakelplsavrfmeelgecafgkiykghlylpgmdhaqlvaiktlkdyn
npqqwmefqqeaslmaelhhpnivcllgavtqeqpvcmlfeyinqgdlheflimrsphsd
vgcssdedgtvkssldhgdflhiaiqiaagmeylsshffvhkdlaarniligeqlhvkis
dlglsreiysadyyrvqsksllpirwmppeaimygkfssdsdiwsfgvvlweifsfglqp
yygfsnqeviemvrkrqllpcsedcpprmyslmtecwneipsrrprfkdihvrlrswegl
hhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6tu9B (B:)
akelplsavrfmeelgecafgkiykghlylhaqlvaiktlkynnpqqwmefqqeaslmae
lhhpnivcllgavtqeqpvcmlfeyinqgdlheflimrsldhgdflhiaiqiaagmeyls
shffvhkdlaarniligeqlhvkisdlgleiysadyyrvqsksllpirwmppeaimygkf
ssdsdiwsfgvvlweifsfglqpyygfsnqeviemvrkrqllpcsedcpprmyslmtecw
neipsrrprfkdihvrlrswe