PDB entry 6tth

View 6tth on RCSB PDB site
Description: pkm2 in complex with l-threonine
Deposited on 2019-12-27, released 2020-01-15
The last revision was dated 2020-07-29, with a file datestamp of 2020-06-29.
Experiment type: EM
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Pyruvate kinase PKM
    Species: Homo sapiens [TaxId:9606]
    Gene: PKM, OIP3, PK2, PK3, PKM2
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Pyruvate kinase PKM
    Species: Homo sapiens [TaxId:9606]
    Gene: PKM, OIP3, PK2, PK3, PKM2
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Pyruvate kinase PKM
    Species: Homo sapiens [TaxId:9606]
    Gene: PKM, OIP3, PK2, PK3, PKM2
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Pyruvate kinase PKM
    Species: Homo sapiens [TaxId:9606]
    Gene: PKM, OIP3, PK2, PK3, PKM2
    Database cross-references and differences (RAF-indexed):
  • Heterogens: THR, FBP, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6tthA (A:)
mgsshhhhhhssglvprgskphseagtafiqtqqlhaamadtflehmcrldidsppitar
ntgiictigpasrsvetlkemiksgmnvarlnfshgtheyhaetiknvrtatesfasdpi
lyrpvavaldtkgpeirtglikgsgtaevelkkgatlkitldnaymekcdenilwldykn
ickvvevgskiyvddglislqvkqkgadflvtevenggslgskkgvnlpgaavdlpavse
kdiqdlkfgveqdvdmvfasfirkasdvhevrkvlgekgknikiiskienhegvrrfdei
leasdgimvargdlgieipaekvflaqkmmigrcnragkpvicatqmlesmikkprptra
egsdvanavldgadcimlsgetakgdypleavrmqhliareaeaaiyhlqlfeelrrlap
itsdpteatavgaveasfkccsgaiivltksgrsahqvaryrprapiiavtrnpqtarqa
hlyrgifpvlckdpvqeawaedvdlrvnfamnvgkargffkkgdvvivltgwrpgsgftn
tmrvvpvp

    Sequence, based on observed residues (ATOM records):
    >6tthA (A:)
madtflehmcrldidsppitarntgiictigpasrsvetlkemiksgmnvarlnfshgth
eyhaetiknvrtatesfasdpilyrpvavaldtkgplpavsekdiqdlkfgveqdvdmvf
asfirkasdvhevrkvlgekgknikiiskienhegvrrfdeileasdgimvargdlgiei
paekvflaqkmmigrcnragkpvicatqmlesmikkprptraegsdvanavldgadciml
sgetakgdypleavrmqhliareaeaaiyhlqlfeelrrlapitsdpteatavgaveasf
kccsgaiivltksgrsahqvaryrprapiiavtrnpqtarqahlyrgifpvlckdpvqea
waedvdlrvnfamnvgkargffkkgdvvivltgwrpgsgftntmrvvpvp

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6tthB (B:)
mgsshhhhhhssglvprgskphseagtafiqtqqlhaamadtflehmcrldidsppitar
ntgiictigpasrsvetlkemiksgmnvarlnfshgtheyhaetiknvrtatesfasdpi
lyrpvavaldtkgpeirtglikgsgtaevelkkgatlkitldnaymekcdenilwldykn
ickvvevgskiyvddglislqvkqkgadflvtevenggslgskkgvnlpgaavdlpavse
kdiqdlkfgveqdvdmvfasfirkasdvhevrkvlgekgknikiiskienhegvrrfdei
leasdgimvargdlgieipaekvflaqkmmigrcnragkpvicatqmlesmikkprptra
egsdvanavldgadcimlsgetakgdypleavrmqhliareaeaaiyhlqlfeelrrlap
itsdpteatavgaveasfkccsgaiivltksgrsahqvaryrprapiiavtrnpqtarqa
hlyrgifpvlckdpvqeawaedvdlrvnfamnvgkargffkkgdvvivltgwrpgsgftn
tmrvvpvp

    Sequence, based on observed residues (ATOM records):
    >6tthB (B:)
madtflehmcrldidsppitarntgiictigpasrsvetlkemiksgmnvarlnfshgth
eyhaetiknvrtatesfasdpilyrpvavaldtkgplpavsekdiqdlkfgveqdvdmvf
asfirkasdvhevrkvlgekgknikiiskienhegvrrfdeileasdgimvargdlgiei
paekvflaqkmmigrcnragkpvicatqmlesmikkprptraegsdvanavldgadciml
sgetakgdypleavrmqhliareaeaaiyhlqlfeelrrlapitsdpteatavgaveasf
kccsgaiivltksgrsahqvaryrprapiiavtrnpqtarqahlyrgifpvlckdpvqea
waedvdlrvnfamnvgkargffkkgdvvivltgwrpgsgftntmrvvpvp

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6tthC (C:)
mgsshhhhhhssglvprgskphseagtafiqtqqlhaamadtflehmcrldidsppitar
ntgiictigpasrsvetlkemiksgmnvarlnfshgtheyhaetiknvrtatesfasdpi
lyrpvavaldtkgpeirtglikgsgtaevelkkgatlkitldnaymekcdenilwldykn
ickvvevgskiyvddglislqvkqkgadflvtevenggslgskkgvnlpgaavdlpavse
kdiqdlkfgveqdvdmvfasfirkasdvhevrkvlgekgknikiiskienhegvrrfdei
leasdgimvargdlgieipaekvflaqkmmigrcnragkpvicatqmlesmikkprptra
egsdvanavldgadcimlsgetakgdypleavrmqhliareaeaaiyhlqlfeelrrlap
itsdpteatavgaveasfkccsgaiivltksgrsahqvaryrprapiiavtrnpqtarqa
hlyrgifpvlckdpvqeawaedvdlrvnfamnvgkargffkkgdvvivltgwrpgsgftn
tmrvvpvp

    Sequence, based on observed residues (ATOM records):
    >6tthC (C:)
madtflehmcrldidsppitarntgiictigpasrsvetlkemiksgmnvarlnfshgth
eyhaetiknvrtatesfasdpilyrpvavaldtkgplpavsekdiqdlkfgveqdvdmvf
asfirkasdvhevrkvlgekgknikiiskienhegvrrfdeileasdgimvargdlgiei
paekvflaqkmmigrcnragkpvicatqmlesmikkprptraegsdvanavldgadciml
sgetakgdypleavrmqhliareaeaaiyhlqlfeelrrlapitsdpteatavgaveasf
kccsgaiivltksgrsahqvaryrprapiiavtrnpqtarqahlyrgifpvlckdpvqea
waedvdlrvnfamnvgkargffkkgdvvivltgwrpgsgftntmrvvpvp

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6tthD (D:)
mgsshhhhhhssglvprgskphseagtafiqtqqlhaamadtflehmcrldidsppitar
ntgiictigpasrsvetlkemiksgmnvarlnfshgtheyhaetiknvrtatesfasdpi
lyrpvavaldtkgpeirtglikgsgtaevelkkgatlkitldnaymekcdenilwldykn
ickvvevgskiyvddglislqvkqkgadflvtevenggslgskkgvnlpgaavdlpavse
kdiqdlkfgveqdvdmvfasfirkasdvhevrkvlgekgknikiiskienhegvrrfdei
leasdgimvargdlgieipaekvflaqkmmigrcnragkpvicatqmlesmikkprptra
egsdvanavldgadcimlsgetakgdypleavrmqhliareaeaaiyhlqlfeelrrlap
itsdpteatavgaveasfkccsgaiivltksgrsahqvaryrprapiiavtrnpqtarqa
hlyrgifpvlckdpvqeawaedvdlrvnfamnvgkargffkkgdvvivltgwrpgsgftn
tmrvvpvp

    Sequence, based on observed residues (ATOM records):
    >6tthD (D:)
madtflehmcrldidsppitarntgiictigpasrsvetlkemiksgmnvarlnfshgth
eyhaetiknvrtatesfasdpilyrpvavaldtkgplpavsekdiqdlkfgveqdvdmvf
asfirkasdvhevrkvlgekgknikiiskienhegvrrfdeileasdgimvargdlgiei
paekvflaqkmmigrcnragkpvicatqmlesmikkprptraegsdvanavldgadciml
sgetakgdypleavrmqhliareaeaaiyhlqlfeelrrlapitsdpteatavgaveasf
kccsgaiivltksgrsahqvaryrprapiiavtrnpqtarqahlyrgifpvlckdpvqea
waedvdlrvnfamnvgkargffkkgdvvivltgwrpgsgftntmrvvpvp