PDB entry 6tpj

View 6tpj on RCSB PDB site
Description: crystal structure of the orexin-2 receptor in complex with suvorexant at 2.76 a resolution
Deposited on 2019-12-13, released 2020-01-01
The last revision was dated 2020-03-11, with a file datestamp of 2020-03-06.
Experiment type: XRAY
Resolution: 2.74 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Orexin receptor type 2,GlgA glycogen synthase,Hypocretin receptor-2
    Species: Homo sapiens [TaxId:9606]
    Gene: HCRTR2
    Database cross-references and differences (RAF-indexed):
    • Uniprot O43614 (Start-264)
      • engineered mutation (64)
      • engineered mutation (101)
      • engineered mutation (110)
      • engineered mutation (152)
      • engineered mutation (180)
      • engineered mutation (212)
      • engineered mutation (216)
      • engineered mutation (229)
      • engineered mutation (243)
      • engineered mutation (252)
    • Uniprot Q9V2J8 (265-460)
    • Uniprot Q548Y0 (461-555)
      • engineered mutation (477)
      • engineered mutation (485)
      • engineered mutation (514)
      • engineered mutation (548-550)
  • Chain 'B':
    Compound: Orexin receptor type 2,GlgA glycogen synthase,Hypocretin receptor-2
    Species: Homo sapiens [TaxId:9606]
    Gene: HCRTR2
    Database cross-references and differences (RAF-indexed):
    • Uniprot O43614 (Start-264)
      • engineered mutation (64)
      • engineered mutation (101)
      • engineered mutation (110)
      • engineered mutation (152)
      • engineered mutation (180)
      • engineered mutation (212)
      • engineered mutation (216)
      • engineered mutation (229)
      • engineered mutation (243)
      • engineered mutation (252)
    • Uniprot Q9V2J8 (265-460)
    • Uniprot Q548Y0 (461-555)
      • engineered mutation (477)
      • engineered mutation (485)
      • engineered mutation (514)
      • engineered mutation (548-550)
  • Heterogens: SUV, OLA, NH4, PG4, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6tpjA (A:)
qdldykddddkmsgtkledsppcrdwssaseldetqeplldptdyddeeflrylwreylh
pkeyawvliagyiivfvvalignvlvcvavwknhhmrtvtnlfivnlslaavlvtitclp
atlvvditetwffgqslckvipylqtvsvsvsaltlscialdrwyaichplmfkstakra
lnsiviiwivsciimipqaivmecstvfpgladkttaftvcderwggeiapkmyhicffl
vtyaaplclmvllylqifrklwcrqgidcsfwnesyltgsrderkksllskfgmdegvtf
mfigrfdrgqkgvdvllkaieilsskkefqemrfiiigkgdpelegwarsleekhgnvkv
itemlsrefvrelygsvdfviipsyfepfglvaleamclgaipiasavgglrdiitnetg
ilvkagdpgelanailkalelsrsdlskfrenckkramsfskqirarrktarmlmvvvlv
faicyapisilnvlkrvfgmfahtedretvyawfafshwlvyansaanpiiynflsgkfr
eefkaafswwwlgvhhhhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6tpjA (A:)
ylhpkeyawvliagyiivfvvalignvlvcvavwknhhmrtvtnlfivnlslaavlvtit
clpatlvvditetwffgqslckvipylqtvsvsvsaltlscialdrwyaichplmfksta
kralnsiviiwivsciimipqaivmecstvfpgladkttaftvcderwggeiapkmyhic
fflvtyaaplclmvllylqifrklwcrqgidcsfwnesyltgsrderkksllskfgmdeg
vtfmfigrfdrgqkgvdvllkaieilsskkefqemrfiiigkgdpelegwarsleekhgn
vkvitemlsrefvrelygsvdfviipsyfepfglvaleamclgaipiasavgglrdiitn
etgilvkagdpgelanailkalelsrsdlskfrenckkramsfskqirarrktarmlmvv
vlvfaicyapisilnvlkrvfgmfahtedretvyawfafshwlvyansaanpiiynflsg
kfreefkaafswwwlgvhh

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6tpjB (B:)
qdldykddddkmsgtkledsppcrdwssaseldetqeplldptdyddeeflrylwreylh
pkeyawvliagyiivfvvalignvlvcvavwknhhmrtvtnlfivnlslaavlvtitclp
atlvvditetwffgqslckvipylqtvsvsvsaltlscialdrwyaichplmfkstakra
lnsiviiwivsciimipqaivmecstvfpgladkttaftvcderwggeiapkmyhicffl
vtyaaplclmvllylqifrklwcrqgidcsfwnesyltgsrderkksllskfgmdegvtf
mfigrfdrgqkgvdvllkaieilsskkefqemrfiiigkgdpelegwarsleekhgnvkv
itemlsrefvrelygsvdfviipsyfepfglvaleamclgaipiasavgglrdiitnetg
ilvkagdpgelanailkalelsrsdlskfrenckkramsfskqirarrktarmlmvvvlv
faicyapisilnvlkrvfgmfahtedretvyawfafshwlvyansaanpiiynflsgkfr
eefkaafswwwlgvhhhhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6tpjB (B:)
reylhpkeyawvliagyiivfvvalignvlvcvavwknhhmrtvtnlfivnlslaavlvt
itclpatlvvditetwffgqslckvipylqtvsvsvsaltlscialdrwyaichplmfks
takralnsiviiwivsciimipqaivmecstvfpgladkttaftvcderwggeiapkmyh
icfflvtyaaplclmvllylqifrklwcrqgidcsfwnesyltgsrderkksllskfgmd
egvtfmfigrfdrgqkgvdvllkaieilsskkefqemrfiiigkgdpelegwarsleekh
gnvkvitemlsrefvrelygsvdfviipsyfepfglvaleamclgaipiasavgglrdii
tnetgilvkagdpgelanailkalelsrsdlskfrenckkramsfskqirarrktarmlm
vvvlvfaicyapisilnvlkrvfgmfahtedretvyawfafshwlvyansaanpiiynfl
sgkfreefkaafswwwlgvhh