PDB entry 6tm7

View 6tm7 on RCSB PDB site
Description: Human 14-3-3 sigma isoform in complex with PLP
Class: signaling protein
Keywords: human protein, h14-3-3sigma, signaling protein, complex, pyridoxal phosphate, PLP
Deposited on 2019-12-03, released 2020-03-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-04-29, with a file datestamp of 2020-04-24.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.12 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 14-3-3 protein sigma
    Species: Homo sapiens [TaxId:9606]
    Gene: SFN, HME1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P31947 (28-End)
      • expression tag (23-27)
    Domains in SCOPe 2.08: d6tm7a1, d6tm7a2
  • Chain 'B':
    Compound: 14-3-3 protein sigma
    Species: Homo sapiens [TaxId:9606]
    Gene: SFN, HME1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P31947 (28-End)
      • expression tag (23-27)
    Domains in SCOPe 2.08: d6tm7b1, d6tm7b2
  • Heterogens: PLP, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6tm7A (A:)
msyyhhhhhhdydipttenlyfqgamgsmerasliqkaklaeqaeryedmaafmkgavek
geelsceernllsvayknvvggqraawrvlssieqksneegseekgpevreyrekvetel
qgvcdtvlglldshlikeagdaesrvfylkmkgdyyrylaevatgddkkriidsarsayq
eamdiskkempptnpirlglalnfsvfhyeianspeeaislakttfdeamadlhtlseds
ykdstlimqllrdnltlwtadnageeggeapqepqs

    Sequence, based on observed residues (ATOM records): (download) 
    >6tm7A (A:)
gamgsmerasliqkaklaeqaeryedmaafmkgavekgeelsceernllsvayknvvggq
raawrvlssieqksnekgpevreyrekvetelqgvcdtvlglldshlikeagdaesrvfy
lkmkgdyyrylaevatgddkkriidsarsayqeamdiskkempptnpirlglalnfsvfh
yeianspeeaislakttfdeamadlhkdstlimqllrdnltlwt

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6tm7B (B:)
msyyhhhhhhdydipttenlyfqgamgsmerasliqkaklaeqaeryedmaafmkgavek
geelsceernllsvayknvvggqraawrvlssieqksneegseekgpevreyrekvetel
qgvcdtvlglldshlikeagdaesrvfylkmkgdyyrylaevatgddkkriidsarsayq
eamdiskkempptnpirlglalnfsvfhyeianspeeaislakttfdeamadlhtlseds
ykdstlimqllrdnltlwtadnageeggeapqepqs

    Sequence, based on observed residues (ATOM records): (download) 
    >6tm7B (B:)
gamgsmerasliqkaklaeqaeryedmaafmkgavekgeelsceernllsvayknvvggq
raawrvlssieqksnekgpevreyrekvetelqgvcdtvlglldshliagdaesrvfylk
mkgdyyrylaevatgddkkriidsarsayqeamdiskkempptnpirlglalnfsvfhye
ianspeeaislakttfdeamadlhtkdstlimqllrdnltlwt