PDB entry 6tle

View 6tle on RCSB PDB site
Description: Human Eg5 motor domain mutant E344K
Class: motor protein
Keywords: Eg5 motor domain mutant E344K, KIF11 motor domain mutant E344K, human syndrome associated Eg5 mutant, MOTOR PROTEIN
Deposited on 2019-12-02, released 2021-06-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-06-30, with a file datestamp of 2021-06-25.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: N/A
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Kinesin-like protein KIF11
    Species: Homo sapiens [TaxId:9606]
    Gene: KIF11, EG5, KNSL1, TRIP5
    Database cross-references and differences (RAF-indexed):
    • Uniprot P52732
      • engineered mutation (342)
    Domains in SCOPe 2.08: d6tlea_
  • Chain 'B':
    Compound: Kinesin-like protein KIF11
    Species: Homo sapiens [TaxId:9606]
    Gene: KIF11, EG5, KNSL1, TRIP5
    Database cross-references and differences (RAF-indexed):
    • Uniprot P52732
      • engineered mutation (342)
    Domains in SCOPe 2.08: d6tleb_
  • Heterogens: MG, ADP, NO3, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6tleA (A:)
asqpnssakkkeekgkniqvvvrcrpfnlaerkasahsivecdpvrkevsvrtggladks
srktytfdmvfgastkqidvyrsvvcpildevimgynctifaygqtgtgktftmegersp
neeytweedplagiiprtlhqifekltdngtefsvkvslleiyneelfdllnpssdvser
lqmfddprnkrgviikgleeitvhnkdevyqilekgaakrttaatlmnayssrshsvfsv
tihmkettidgeelvkigklnlvdlagsenigrsgavdkrareagninqslltlgrvita
lvertphvpyreskltrilqdslggrtrtsiiatispaslnlketlstleyahrakniln
kpevnqk

    Sequence, based on observed residues (ATOM records): (download) 
    >6tleA (A:)
kniqvvvrcrpfnlaerkasahsivecdpvrkevsvrtggladkssrktytfdmvfgast
kqidvyrsvvcpildevimgynctifaygqtgtgktftmegerspneeytweedplagii
prtlhqifekltdngtefsvkvslleiyneelfdllnpssdvserlqmfddprnkrgvii
kgleeitvhnkdevyqilekgaakrttaatlmnayssrshsvfsvtihmkettidgeelv
kigklnlvdlagserareagninqslltlgrvitalvertphvpyreskltrilqdslgg
rtrtsiiatispaslnlketlstleyahraknilnkpe

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6tleB (B:)
asqpnssakkkeekgkniqvvvrcrpfnlaerkasahsivecdpvrkevsvrtggladks
srktytfdmvfgastkqidvyrsvvcpildevimgynctifaygqtgtgktftmegersp
neeytweedplagiiprtlhqifekltdngtefsvkvslleiyneelfdllnpssdvser
lqmfddprnkrgviikgleeitvhnkdevyqilekgaakrttaatlmnayssrshsvfsv
tihmkettidgeelvkigklnlvdlagsenigrsgavdkrareagninqslltlgrvita
lvertphvpyreskltrilqdslggrtrtsiiatispaslnlketlstleyahrakniln
kpevnqk

    Sequence, based on observed residues (ATOM records): (download) 
    >6tleB (B:)
kniqvvvrcrpfsivecdpvrkevsvrtggdkssrktytfdmvfgastkqidvyrsvvcp
ildevimgynctifaygqtgtgktftmegerytweedplagiiprtlhqifekltdngte
fsvkvslleiyneelfdllnpssdvserlqmfddprnkrgviikgleeitvhnkdevyqi
lekgaakrttaatlmnayssrshsvfsvtihmkettidgeelvkigklnlvdlagseare
agninqslltlgrvitalvertphvpyreskltrilqdslggrtrtsiiatispaslnlk
etlstleyahraknilnkpe