PDB entry 6tld

View 6tld on RCSB PDB site
Description: crystal structure of schistosoma mansoni hdac8 complexed with a triazole hydroxamate inhibitor 2
Deposited on 2019-12-02, released 2019-12-18
The last revision was dated 2020-04-08, with a file datestamp of 2020-04-03.
Experiment type: XRAY
Resolution: 1.61 Å
R-factor: N/A
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histone deacetylase
    Species: Schistosoma mansoni [TaxId:6183]
    Gene: HDAC8
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Histone deacetylase
    Species: Schistosoma mansoni [TaxId:6183]
    Gene: HDAC8
    Database cross-references and differences (RAF-indexed):
    • Uniprot A5H660 (Start-440)
      • expression tag (441-446)
  • Chain 'C':
    Compound: Histone deacetylase
    Species: Schistosoma mansoni [TaxId:6183]
    Gene: HDAC8
    Database cross-references and differences (RAF-indexed):
    • Uniprot A5H660 (Start-440)
      • expression tag (441-446)
  • Chain 'D':
    Compound: Histone deacetylase
    Species: Schistosoma mansoni [TaxId:6183]
    Gene: HDAC8
    Database cross-references and differences (RAF-indexed):
  • Heterogens: NK5, ZN, K, DMF, GOL, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6tldA (A:)
hmsvgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeav
tafhsteyvdalkklqmlhceekeltaddellmdsfslnydcpgfpsvfdyslaavqgsl
aaasalicrhcevvinwgggwhhakrseasgfcylndivlaihrlvsstppetspnrqtr
vlyvdldlhhgdgveeafwysprvvtfsvhhaspgffpgtgtwnmvdndklpiflngagr
grfsafnlpleegindldwsnaigpildslniviqpsyvvvqcgadclatdphrifrltn
fypnlnldsdcdsecslsgylyaikkilswkvptlilggggynfpdtarlwtrvtaltie
evkgkkmtispeipehsyfsrygpdfeldidyfpheshnktldsiqkhhrrileqlrnya
dlnkliydydqvyqlynltgmgslvpr

    Sequence, based on observed residues (ATOM records):
    >6tldA (A:)
svgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeavta
fhsteyvdalkklqmlhceekeltaddellmdsfslnydcpgfpsvfdyslaavqgslaa
asalicrhcevvinwgggwhhakrseasgfcylndivlaihrlvssqtrvlyvdldlhhg
dgveeafwysprvvtfsvhhaspgffpgtgtwnklpiflngagrgrfsafnlpleegind
ldwsnaigpildslniviqpsyvvvqcgadclatdphrifrltnfypslsgylyaikkil
swkvptlilggggynfpdtarlwtrvtaltieevkgkkmtispeipehsyfsrygpdfel
didyfpdsiqkhhrrileqlrnyadlnkliydydqvyqly

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6tldB (B:)
hmsvgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeav
tafhsteyvdalkklqmlhceekeltaddellmdsfslnydcpgfpsvfdyslaavqgsl
aaasalicrhcevvinwgggwhhakrseasgfcylndivlaihrlvsstppetspnrqtr
vlyvdldlhhgdgveeafwysprvvtfsvhhaspgffpgtgtwnmvdndklpiflngagr
grfsafnlpleegindldwsnaigpildslniviqpsyvvvqcgadclatdphrifrltn
fypnlnldsdcdsecslsgylyaikkilswkvptlilggggynfpdtarlwtrvtaltie
evkgkkmtispeipehsyfsrygpdfeldidyfpheshnktldsiqkhhrrileqlrnya
dlnkliydydqvyqlynltgmgslvpr

    Sequence, based on observed residues (ATOM records):
    >6tldB (B:)
svgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeavta
fhsteyvdalkklqmlhceeltaddellmdsfslnydcpgfpsvfdyslaavqgslaaas
alicrhcevvinwgggwhhakrseasgfcylndivlaihrlvsstqtrvlyvdldlhhgd
gveeafwysprvvtfsvhhaspgffpgtgtwnmlpiflngagrgrfsafnlpleegindl
dwsnaigpildslniviqpsyvvvqcgadclatdphrifrltnfypslsgylyaikkils
wkvptlilggggynfpdtarlwtrvtaltieevkgkkmtispeipehsyfsrygpdfeld
idyfphetldsiqkhhrrileqlrnyadlnkliydydqvyqlynltgmgslvpr

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6tldC (C:)
hmsvgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeav
tafhsteyvdalkklqmlhceekeltaddellmdsfslnydcpgfpsvfdyslaavqgsl
aaasalicrhcevvinwgggwhhakrseasgfcylndivlaihrlvsstppetspnrqtr
vlyvdldlhhgdgveeafwysprvvtfsvhhaspgffpgtgtwnmvdndklpiflngagr
grfsafnlpleegindldwsnaigpildslniviqpsyvvvqcgadclatdphrifrltn
fypnlnldsdcdsecslsgylyaikkilswkvptlilggggynfpdtarlwtrvtaltie
evkgkkmtispeipehsyfsrygpdfeldidyfpheshnktldsiqkhhrrileqlrnya
dlnkliydydqvyqlynltgmgslvpr

    Sequence, based on observed residues (ATOM records):
    >6tldC (C:)
svgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeavta
fhsteyvdalkklqmlhceeeltaddellmdsfslnydcpgfpsvfdyslaavqgslaaa
salicrhcevvinwgggwhhakrseasgfcylndivlaihrlvsstqtrvlyvdldlhhg
dgveeafwysprvvtfsvhhaspgffpgtgtwnmvdndklpiflngagrgrfsafnlple
egindldwsnaigpildslniviqpsyvvvqcgadclatdphrifrltnfypslsgylya
ikkilswkvptlilggggynfpdtarlwtrvtaltieevkgkkmtispeipehsyfsryg
pdfeldidyfpheldsiqkhhrrileqlrnyadlnkliydydqvyqlynltgmgslvpr

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6tldD (D:)
hmsvgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeav
tafhsteyvdalkklqmlhceekeltaddellmdsfslnydcpgfpsvfdyslaavqgsl
aaasalicrhcevvinwgggwhhakrseasgfcylndivlaihrlvsstppetspnrqtr
vlyvdldlhhgdgveeafwysprvvtfsvhhaspgffpgtgtwnmvdndklpiflngagr
grfsafnlpleegindldwsnaigpildslniviqpsyvvvqcgadclatdphrifrltn
fypnlnldsdcdsecslsgylyaikkilswkvptlilggggynfpdtarlwtrvtaltie
evkgkkmtispeipehsyfsrygpdfeldidyfpheshnktldsiqkhhrrileqlrnya
dlnkliydydqvyqlynltgmgslvpr

    Sequence, based on observed residues (ATOM records):
    >6tldD (D:)
svgivygdqyrqlccsspkfgdryalvmdlinayklipelsrvpplqwdspsrmyeavta
fhsteyvdalkklqmlhceekeltaddellmdsfslnydcpgfpsvfdyslaavqgslaa
asalicrhcevvinwgggwhhakrseasgfcylndivlaihrlvssqtrvlyvdldlhhg
dgveeafwysprvvtfsvhhaspgffpgtgtwnmpiflngagrgrfsafnlpleegindl
dwsnaigpildslniviqpsyvvvqcgadclatdphrifrltnfypnslsgylyaikkil
swkvptlilggggynfpdtarlwtrvtaltieevkgkkmtispeipehsyfsrygpdfel
didyfpdsiqkhhrrileqlrnyadlnkliydydqvyqly