PDB entry 6tl5

View 6tl5 on RCSB PDB site
Description: Three dimensional structure of human carbonic anhydrase IX in complex with sulfonamide
Class: lyase
Keywords: lyase
Deposited on 2019-12-01, released 2020-12-16
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-12-16, with a file datestamp of 2020-12-11.
Experiment type: XRAY
Resolution: 2.21 Å
R-factor: N/A
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Carbonic anhydrase 9
    Species: Homo sapiens [TaxId:9606]
    Gene: CA9, G250, MN
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16790 (Start-256)
      • engineered mutation (39)
      • conflict (211)
    Domains in SCOPe 2.08: d6tl5a_
  • Chain 'B':
    Compound: Carbonic anhydrase 9
    Species: Homo sapiens [TaxId:9606]
    Gene: CA9, G250, MN
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16790 (Start-256)
      • engineered mutation (39)
      • conflict (211)
    Domains in SCOPe 2.08: d6tl5b_
  • Chain 'C':
    Compound: Carbonic anhydrase 9
    Species: Homo sapiens [TaxId:9606]
    Gene: CA9, G250, MN
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16790 (Start-256)
      • engineered mutation (39)
      • conflict (211)
    Domains in SCOPe 2.08: d6tl5c_
  • Chain 'D':
    Compound: Carbonic anhydrase 9
    Species: Homo sapiens [TaxId:9606]
    Gene: CA9, G250, MN
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16790 (Start-256)
      • engineered mutation (39)
      • conflict (211)
    Domains in SCOPe 2.08: d6tl5d_
  • Heterogens: MKQ, ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6tl5A (A:)
gpdqshwryggdppwprvspacagrfqspvdirpqlaafspalrplellgfqlpplpelr
lrnnghsvqltlppglemalgpgreyralqlhlhwgaagrpgsehtveghrfpaeihvvh
lstafarvdealgrpgglavlaafleegpeensayeqllsrleeiaeegsetqvpgldis
allpsdfsryfqyegslttppcaqgviwtvfqqtvmlsakqlhtlsdtlwgpgdsrlqln
fratqplngrvieasfp

    Sequence, based on observed residues (ATOM records): (download) 
    >6tl5A (A:)
wryggdppwprvspacagrfqspvdirpqlaafspalrplellgfqlpplpelrlrnngh
svqltlppglemalgpgreyralqlhlhwgaagrpgsehtveghrfpaeihvvhlstafa
rvdealgrpgglavlaafleegpeensayeqllsrleeiaeegsetqvpgldisallpsd
fsryfqyegslttppcaqgviwtvfqqtvmlsakqlhtlsdtlwgpgdsrlqlnfratqp
lngrvieasfp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6tl5B (B:)
gpdqshwryggdppwprvspacagrfqspvdirpqlaafspalrplellgfqlpplpelr
lrnnghsvqltlppglemalgpgreyralqlhlhwgaagrpgsehtveghrfpaeihvvh
lstafarvdealgrpgglavlaafleegpeensayeqllsrleeiaeegsetqvpgldis
allpsdfsryfqyegslttppcaqgviwtvfqqtvmlsakqlhtlsdtlwgpgdsrlqln
fratqplngrvieasfp

    Sequence, based on observed residues (ATOM records): (download) 
    >6tl5B (B:)
wryggdppwprvspacagrfqspvdirpqlaafspalrplellgfqlpplpelrlrnngh
svqltlppglemalgpgreyralqlhlhwgaagrpgsehtveghrfpaeihvvhlstafa
rvdealgrpgglavlaafleegpeensayeqllsrleeiaeegsetqvpgldisallpsd
fsryfqyegslttppcaqgviwtvfqqtvmlsakqlhtlsdtlwgpgdsrlqlnfratqp
lngrvieasfp

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6tl5C (C:)
gpdqshwryggdppwprvspacagrfqspvdirpqlaafspalrplellgfqlpplpelr
lrnnghsvqltlppglemalgpgreyralqlhlhwgaagrpgsehtveghrfpaeihvvh
lstafarvdealgrpgglavlaafleegpeensayeqllsrleeiaeegsetqvpgldis
allpsdfsryfqyegslttppcaqgviwtvfqqtvmlsakqlhtlsdtlwgpgdsrlqln
fratqplngrvieasfp

    Sequence, based on observed residues (ATOM records): (download) 
    >6tl5C (C:)
wryggdppwprvspacagrfqspvdirpqlaafspalrplellgfqlpplpelrlrnngh
svqltlppglemalgpgreyralqlhlhwgaagrpgsehtveghrfpaeihvvhlstafa
rvdealgrpgglavlaafleegpeensayeqllsrleeiaeegsetqvpgldisallpsd
fsryfqyegslttppcaqgviwtvfqqtvmlsakqlhtlsdtlwgpgdsrlqlnfratqp
lngrvieasfp

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6tl5D (D:)
gpdqshwryggdppwprvspacagrfqspvdirpqlaafspalrplellgfqlpplpelr
lrnnghsvqltlppglemalgpgreyralqlhlhwgaagrpgsehtveghrfpaeihvvh
lstafarvdealgrpgglavlaafleegpeensayeqllsrleeiaeegsetqvpgldis
allpsdfsryfqyegslttppcaqgviwtvfqqtvmlsakqlhtlsdtlwgpgdsrlqln
fratqplngrvieasfp

    Sequence, based on observed residues (ATOM records): (download) 
    >6tl5D (D:)
wprvspacagrfqspvdirpqlaafspalrplellgfqlpplpelrlrnnghsvqltlpp
glemalgpgreyralqlhlhwgaagrpgsehtveghrfpaeihvvhlstafarvdealgr
pgglavlaafleegpeensayeqllsrleeiaeegsetqvpgldisallpsdfsryfqye
gslttppcaqgviwtvfqqtvmlsakqlhtlsdtlwgpgdsrlqlnfratqplngrviea
sfp