PDB entry 6tfv

View 6tfv on RCSB PDB site
Description: crystal structure of egfr t790m/v948r in complex with covalent pyrrolopyrimidine 18b
Deposited on 2019-11-14, released 2020-09-30
The last revision was dated 2020-11-04, with a file datestamp of 2020-10-30.
Experiment type: XRAY
Resolution: 1.5 Å
R-factor: N/A
AEROSPACI score: 0.57 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB, ERBB1, HER1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • engineered mutation (100)
      • engineered mutation (258)
  • Chain 'B':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB, ERBB1, HER1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • engineered mutation (100)
      • engineered mutation (258)
  • Heterogens: N7Q, EDO, SO4, CL, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6tfvA (A:)
gshmasgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelre
atspkankeildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdni
gsqyllnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekey
haeggkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilek
gerlpqppictidvymimrkcwmidadsrpkfreliiefskmardpqrylviqgdermhl
psptdsnfyralmdeedmddvvdadeylipqqg

    Sequence, based on observed residues (ATOM records):
    >6tfvA (A:)
nqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatskankeil
deayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwcvq
iakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglkvpikwmalesilhriythqsd
vwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimrkcwmidad
srpkfreliiefskmardpqrylviqgde

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6tfvB (B:)
gshmasgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelre
atspkankeildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdni
gsqyllnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekey
haeggkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilek
gerlpqppictidvymimrkcwmidadsrpkfreliiefskmardpqrylviqgdermhl
psptdsnfyralmdeedmddvvdadeylipqqg

    Sequence, based on observed residues (ATOM records):
    >6tfvB (B:)
apnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreakankeil
deayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwcvq
iakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglkvpikwmalesilhriythqsd
vwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimrkcwmidad
srpkfreliiefskmardpqrylviqgd