PDB entry 6te1

View 6te1 on RCSB PDB site
Description: structure of the kdm1a/corest complex with the inhibitor 2-[3-{4- chloro-3-[(4-chlorophenyl)ethynyl]phenyl}-1-(3-morpholin-4-ylpropyl)- 1,4,6,7-tetrahydro-5h-pyrazolo[4,3-c]pyridin-5-yl]-2-oxoethanol
Deposited on 2019-11-11, released 2020-06-03
The last revision was dated 2020-06-03, with a file datestamp of 2020-05-29.
Experiment type: XRAY
Resolution: 3.11 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Lysine-specific histone demethylase 1A
    Species: Homo sapiens [TaxId:9606]
    Gene: KDM1A, AOF2, KDM1, KIAA0601, LSD1
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: rest corepressor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: RCOR1, KIAA0071, RCOR
    Database cross-references and differences (RAF-indexed):
  • Heterogens: N4K, FAD, GOL, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6te1A (A:)
mlsgkkaaaaaaaaaaaatgteagpgtaggsengsevaaqpaglsgpaevgpgavgertp
rkkepprasppgglaeppgsagpqagptvvpgsatpmetgiaetpegrrtsrrkrakvey
remdeslanlsedeyyseeernakaekekklpppppqappeeenesepeepsgvegaafq
srlphdrmtsqeaacfpdiisgpqqtqkvflfirnrtlqlwldnpkiqltfeatlqqlea
pynsdtvlvhrvhsylerhglinfgiykrikplptkktgkviiigsgvsglaaarqlqsf
gmdvtlleardrvggrvatfrkgnyvadlgamvvtglggnpmavvskqvnmelakikqkc
plyeangqavpkekdemveqefnrlleatsylshqldfnvlnnkpvslgqalevviqlqe
khvkdeqiehwkkivktqeelkellnkmvnlkekikelhqqykeasevkpprditaeflv
kskhrdltalckeydelaetqgkleeklqeleanppsdvylssrdrqildwhfanlefan
atplstlslkhwdqdddfeftgshltvrngyscvpvalaegldiklntavrqvrytasgc
eviavntrstsqtfiykcdavlctlplgvlkqqppavqfvpplpewktsavqrmgfgnln
kvvlcfdrvfwdpsvnlfghvgsttasrgelflfwnlykapillalvageaagimenisd
dvivgrclailkgifgssavpqpketvvsrwradpwargsysyvaagssgndydlmaqpi
tpgpsipgapqpiprlffagehtirnypatvhgallsglreagriadqflgamytlprqa
tpgvpaqqspsm

    Sequence, based on observed residues (ATOM records):
    >6te1A (A:)
psgvegaafqsrlphdrmtsqeaacfpdiisgpqqtqkvflfirnrtlqlwldnpkiqlt
featlqqleapynsdtvlvhrvhsylerhglinfgiykrikplptkktgkviiigsgvsg
laaarqlqsfgmdvtlleardrvggrvatfrkgnyvadlgamvvtglggnpmavvskqvn
melakikqkcplyeangqavpkekdemveqefnrlleatsylshqldfnvlnnkpvslgq
alevviqlqekhvkdeqiehwkkivktqeelkellnkmvnlkekikelhqqykeasevkp
prditaeflvkskhrdltalckeydelaetqgkleeklqeleanppsdvylssrdrqild
whfanlefanatplstlslkhwdqdddfeftgshltvrngyscvpvalaegldiklntav
rqvrytasgceviavntrstsqtfiykcdavlctlplgvlkqqppavqfvpplpewktsa
vqrmgfgnlnkvvlcfdrvfwdpsvnlfghvgsttasrgelflfwnlykapillalvage
aagimenisddvivgrclailkgifgssavpqpketvvsrwradpwargsysyvaagssg
ndydlmaqpitpgpsipgapqpiprlffagehtirnypatvhgallsglreagriadqfl
gamytl

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6te1B (B:)
mvekgpevsgkrrgrnnaaasasaaaasaaasaacaspaataasgaaassasaaaasaaa
apnngqnkslaaaapngnsssnsweegssgsssdeehggggmrvgpqyqavvpdfdpakl
arrsqerdnlgmlvwspnqnlseakldeyiaiakekhgynmeqalgmlfwhkhnieksla
dlpnftpfpdewtvedkvlfeqafsfhgktfhriqqmlpdksiaslvkfyyswkktrtkt
svmdrharkqkrereesedeleeangnnpidievdqnkeskkevpptetvpqvkkekhst
qaknrakrkppkgmflsqedveavsanataattvlrqldmelvsvkrqiqnikqtnsalk
ekldggiepyrlpeviqkcnarwtteeqllavqairkygrdfqaisdvignksvvqvknf
fvnyrrrfnidevlqeweaehgkeetngpsnqkpvkspdnsikmpeeedeapvldvryas
as

    Sequence, based on observed residues (ATOM records):
    >6te1B (B:)
rkppkgmflsqedveavsanataattvlrqldmelvsvkrqiqnikqtnsalkekldggi
epyrlpeviqkcnarwtteeqllavqairkygrdfqaisdvignksvvqvknffvnyrrr
fnidevlqeweae