PDB entry 6tdr

View 6tdr on RCSB PDB site
Description: Crystal structure of the disulfide engineered HLA-A0201 molecule devoid of peptide (annealed)
Class: immune system
Keywords: MHC Class I molecule, IMMUNE SYSTEM
Deposited on 2019-11-10, released 2020-03-25
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-03-25, with a file datestamp of 2020-03-20.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: N/A
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: MHC class I antigen
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-A
    Database cross-references and differences (RAF-indexed):
    • Uniprot F6IQS1 (Start-275)
      • conflict (84)
      • conflict (139)
      • conflict (245)
    Domains in SCOPe 2.07: d6tdra1, d6tdra2
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
    Domains in SCOPe 2.07: d6tdrb1, d6tdrb2
  • Chain 'C':
    Compound: MHC class I antigen
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-A
    Database cross-references and differences (RAF-indexed):
    • Uniprot F6IQS1 (Start-275)
      • conflict (84)
      • conflict (139)
      • conflict (245)
    Domains in SCOPe 2.07: d6tdrc1, d6tdrc2
  • Chain 'D':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
    Domains in SCOPe 2.07: d6tdrd1, d6tdrd2
  • Heterogens: EDO, NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6tdrA (A:)
    agshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpey
    wdgetrkvkahsqthrvdlgtlrgcynqseagshtvqrmygcdvgsdwrflrgyhqyayd
    gkdyialkedlrswtaadmcaqttkhkweaahvaeqlraylegtcvewlrrylengketl
    qrtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdg
    tfqkwvavvvpsgqeqrytchvqheglpkpltlrwe
    

    Sequence, based on observed residues (ATOM records): (download)
    >6tdrA (A:)
    gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
    dgetrkvkahsqthrvdlgtlrgcynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
    kdyialkedlrswtaadmcaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
    rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
    fqkwvavvvpsgqeqrytchvqheglpkpltlrwe
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >6tdrB (B:)
    miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
    wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >6tdrC (C:)
    agshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpey
    wdgetrkvkahsqthrvdlgtlrgcynqseagshtvqrmygcdvgsdwrflrgyhqyayd
    gkdyialkedlrswtaadmcaqttkhkweaahvaeqlraylegtcvewlrrylengketl
    qrtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdg
    tfqkwvavvvpsgqeqrytchvqheglpkpltlrwe
    

    Sequence, based on observed residues (ATOM records): (download)
    >6tdrC (C:)
    gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
    dgetrkvkahsqthrvdlgtlrgcynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
    kdyialkedlrswtaadmcaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
    rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
    fqkwvavvvpsgqeqrytchvqheglpkpltlrwe
    

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download)
    >6tdrD (D:)
    miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
    wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm