PDB entry 6tco

View 6tco on RCSB PDB site
Description: Crystal structure of the omalizumab Fab Leu158Pro light chain mutant - crystal form I
Class: immune system
Keywords: Fab, Antibody, immunoglobulin, IMMUNE SYSTEM
Deposited on 2019-11-06, released 2020-03-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-03-18, with a file datestamp of 2020-03-13.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Omalizumab Fab Leu158Pro light chain mutant
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6TCO (0-End)
    Domains in SCOPe 2.08: d6tcoa1, d6tcoa2
  • Chain 'B':
    Compound: Omalizumab Fab Leu158Pro light chain mutant
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6TCO (0-End)
    Domains in SCOPe 2.08: d6tcob_
  • Chain 'H':
    Compound: Omalizumab Fab Leu158Pro light chain mutant
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6TCO (0-End)
    Domains in SCOPe 2.08: d6tcoh_
  • Chain 'L':
    Compound: Omalizumab Fab Leu158Pro light chain mutant
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6TCO (0-End)
    Domains in SCOPe 2.08: d6tcol1, d6tcol2
  • Heterogens: SO4, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6tcoA (A:)
diqltqspsslsasvgdrvtitcrasqsvdydgdsymnwyqqkpgkapklliyaasyles
gvpsrfsgsgsgtdftltisslqpedfatyycqqshedpytfgqgtkveikrtvaapsvf
ifppsdeqlksgtasvvcllnnfypreakvqwkvdnapqsgnsqesvteqdskdstysls
stltlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >6tcoA (A:)
diqltqspsslsasvgdrvtitcrasqsvdydgdsymnwyqqkpgkapklliyaasyles
gvpsrfsgsgsgtdftltisslqpedfatyycqqshedpytfgqgtkveikrtvaapsvf
ifppsdeqlksgtasvvcllnnfypreakvqwkvdnapqsgnsqesvteqdskdstysls
stltlskadyekhkvyacevthqglsspvtksfnrg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6tcoB (B:)
evqlvesggglvqpggslrlscavsgysitsgyswnwirqapgkglewvasitydgstny
npsvkgritisrddskntfylqmnslraedtavyycargshyfghwhfavwgqgtlvtvs
sastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqs
sglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkschhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6tcoB (B:)
evqlvesggglvqpggslrlscavsgysitsgyswnwirqapgkglewvasitydgstny
npsvkgritisrddskntfylqmnslraedtavyycargshyfghwhfavwgqgtlvtvs
sastkgpsvfplapsgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglysl
ssvvtvpssslgtqtyicnvnhkpsntkvdkkvep

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6tcoH (H:)
evqlvesggglvqpggslrlscavsgysitsgyswnwirqapgkglewvasitydgstny
npsvkgritisrddskntfylqmnslraedtavyycargshyfghwhfavwgqgtlvtvs
sastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqs
sglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkschhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6tcoH (H:)
evqlvesggglvqpggslrlscavsgysitsgyswnwirqapgkglewvasitydgstny
npsvkgritisrddskntfylqmnslraedtavyycargshyfghwhfavwgqgtlvtvs
sastkgpsvfplapsgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglysl
ssvvtvpssslgtqtyicnvnhkpsntkvdkkvep

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >6tcoL (L:)
diqltqspsslsasvgdrvtitcrasqsvdydgdsymnwyqqkpgkapklliyaasyles
gvpsrfsgsgsgtdftltisslqpedfatyycqqshedpytfgqgtkveikrtvaapsvf
ifppsdeqlksgtasvvcllnnfypreakvqwkvdnapqsgnsqesvteqdskdstysls
stltlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >6tcoL (L:)
diqltqspsslsasvgdrvtitcrasqsvdydgdsymnwyqqkpgkapklliyaasyles
gvpsrfsgsgsgtdftltisslqpedfatyycqqshedpytfgqgtkveikrtvaapsvf
ifppsdeqlksgtasvvcllnnfypreakvqwkvdnapqsgnsqesvteqdskdstysls
stltlskadyekhkvyacevthqglsspvtksfnrg