PDB entry 6t8x

View 6t8x on RCSB PDB site
Description: Crystal structure of MAPKAPK2 (MK2) complexed with PF-3644022 and 5-(4-bromophenyl)-N-[4-(1-piperazinyl)phenyl]-N-(2-pyridinylmethyl)-2-furancarboxamide
Class: immune system
Keywords: kinase, non-ATP competitive inhibitor, type4, IMMUNE SYSTEM
Deposited on 2019-10-25, released 2021-05-12
The last revision prior to the SCOPe 2.07 freeze date was dated 2021-05-12, with a file datestamp of 2021-05-07.
Experiment type: XRAY
Resolution: 2.81 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: MAP kinase-activated protein kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPKAPK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6t8xa_
  • Chain 'B':
    Compound: MAP kinase-activated protein kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPKAPK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6t8xb_
  • Chain 'C':
    Compound: MAP kinase-activated protein kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPKAPK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6t8xc_
  • Chain 'D':
    Compound: MAP kinase-activated protein kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPKAPK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6t8xd_
  • Chain 'E':
    Compound: MAP kinase-activated protein kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPKAPK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6t8xe_
  • Chain 'F':
    Compound: MAP kinase-activated protein kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPKAPK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6t8xf_
  • Heterogens: MW8, B97, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6t8xA (A:)
mgsshhhhhhssgenlyfqgsqqfpqfhvksglqikknaiiddykvtsqvlglgingkvl
qifnkrtqekfalkmlqdcpkarrevelhwrasqcphivrivdvyenlyagrkcllivme
cldggelfsriqdrgdqaftereaseimksigeaiqylhsiniahrdvkpenllytskrp
nailkltdfgfakettshnsltepcytpyyvapevlgpekydkscdmwslgvimyillcg
yppfysnhglaispgmktrirmgqyefpnpewsevseevkmlirnllkteptqrmtitef
mnhpwimqstkvpqeplht

    Sequence, based on observed residues (ATOM records): (download) 
    >6t8xA (A:)
pqfhvksglqikknaiiddykvtsqvlglgingkvlqifnkrtqekfalkmlqdcpkarr
evelhwrasqcphivrivdvyenlyagrkcllivmecldggelfsriqdrgdqafterea
seimksigeaiqylhsiniahrdvkpenllytskrpnailkltdfgfakettsytpyyva
pevlgpekydkscdmwslgvimyillcgyppfysnhglaispgmktrirmgqyefpnpew
sevseevkmlirnllkteptqrmtitefmnhpwimqstk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6t8xB (B:)
mgsshhhhhhssgenlyfqgsqqfpqfhvksglqikknaiiddykvtsqvlglgingkvl
qifnkrtqekfalkmlqdcpkarrevelhwrasqcphivrivdvyenlyagrkcllivme
cldggelfsriqdrgdqaftereaseimksigeaiqylhsiniahrdvkpenllytskrp
nailkltdfgfakettshnsltepcytpyyvapevlgpekydkscdmwslgvimyillcg
yppfysnhglaispgmktrirmgqyefpnpewsevseevkmlirnllkteptqrmtitef
mnhpwimqstkvpqeplht

    Sequence, based on observed residues (ATOM records): (download) 
    >6t8xB (B:)
qfhvksglqikknaiiddykvtsqvlglgingkvlqifnkrtqekfalkmlqdcpkarre
velhwrasqcphivrivdvyenlyagrkcllivmecldggelfsriqdrgdqaftereas
eimksigeaiqylhsiniahrdvkpenllytskrpnailkltdfgfakettstpyyvape
vlgpekydkscdmwslgvimyillcgyppfysnhglaispgmktrirmgqyefpnpewse
vseevkmlirnllkteptqrmtitefmnhpwimqst

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6t8xC (C:)
mgsshhhhhhssgenlyfqgsqqfpqfhvksglqikknaiiddykvtsqvlglgingkvl
qifnkrtqekfalkmlqdcpkarrevelhwrasqcphivrivdvyenlyagrkcllivme
cldggelfsriqdrgdqaftereaseimksigeaiqylhsiniahrdvkpenllytskrp
nailkltdfgfakettshnsltepcytpyyvapevlgpekydkscdmwslgvimyillcg
yppfysnhglaispgmktrirmgqyefpnpewsevseevkmlirnllkteptqrmtitef
mnhpwimqstkvpqeplht

    Sequence, based on observed residues (ATOM records): (download) 
    >6t8xC (C:)
pqfhvksglqikknaiiddykvtsqvlglgingkvlqifnkrtqekfalkmlqdcpkarr
evelhwrasqcphivrivdvyenlyagrkcllivmecldggelfsriqdrgdqafterea
seimksigeaiqylhsiniahrdvkpenllytskrpnailkltdfgfaketttpyyvape
vlgpekydkscdmwslgvimyillcgyppfysnhglaispgmktrirmgqyefpnpewse
vseevkmlirnllkteptqrmtitefmnhpwimqst

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6t8xD (D:)
mgsshhhhhhssgenlyfqgsqqfpqfhvksglqikknaiiddykvtsqvlglgingkvl
qifnkrtqekfalkmlqdcpkarrevelhwrasqcphivrivdvyenlyagrkcllivme
cldggelfsriqdrgdqaftereaseimksigeaiqylhsiniahrdvkpenllytskrp
nailkltdfgfakettshnsltepcytpyyvapevlgpekydkscdmwslgvimyillcg
yppfysnhglaispgmktrirmgqyefpnpewsevseevkmlirnllkteptqrmtitef
mnhpwimqstkvpqeplht

    Sequence, based on observed residues (ATOM records): (download) 
    >6t8xD (D:)
pqfhvksglqikknaiiddykvtsqvlglgingkvlqifnkrtqekfalkmlqdcpkarr
evelhwrasqcphivrivdvyenlyagrkcllivmecldggelfsriqdrgdqafterea
seimksigeaiqylhsiniahrdvkpenllytskrpnailkltdfgfakettcytpyyva
pevlgpekydkscdmwslgvimyillcgyppfysnhglaispgmktrirmgqyefpnpew
sevseevkmlirnllkteptqrmtitefmnhpwimqstkv

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6t8xE (E:)
mgsshhhhhhssgenlyfqgsqqfpqfhvksglqikknaiiddykvtsqvlglgingkvl
qifnkrtqekfalkmlqdcpkarrevelhwrasqcphivrivdvyenlyagrkcllivme
cldggelfsriqdrgdqaftereaseimksigeaiqylhsiniahrdvkpenllytskrp
nailkltdfgfakettshnsltepcytpyyvapevlgpekydkscdmwslgvimyillcg
yppfysnhglaispgmktrirmgqyefpnpewsevseevkmlirnllkteptqrmtitef
mnhpwimqstkvpqeplht

    Sequence, based on observed residues (ATOM records): (download) 
    >6t8xE (E:)
qfhvksglqikknaiiddykvtsqvlglgingkvlqifnkrtqekfalkmlqdcpkarre
velhwrasqcphivrivdvyenlyagrkcllivmecldggelfsriqdrgdqaftereas
eimksigeaiqylhsiniahrdvkpenllytskrpnailkltdfgfakettcytpyyvap
evlgpekydkscdmwslgvimyillcgyppfysnhglaispgmktrirmgqyefpnpews
evseevkmlirnllkteptqrmtitefmnhpwimqst

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6t8xF (F:)
mgsshhhhhhssgenlyfqgsqqfpqfhvksglqikknaiiddykvtsqvlglgingkvl
qifnkrtqekfalkmlqdcpkarrevelhwrasqcphivrivdvyenlyagrkcllivme
cldggelfsriqdrgdqaftereaseimksigeaiqylhsiniahrdvkpenllytskrp
nailkltdfgfakettshnsltepcytpyyvapevlgpekydkscdmwslgvimyillcg
yppfysnhglaispgmktrirmgqyefpnpewsevseevkmlirnllkteptqrmtitef
mnhpwimqstkvpqeplht

    Sequence, based on observed residues (ATOM records): (download) 
    >6t8xF (F:)
qfhvksglqikknaiiddykvtsqvlglgingkvlqifnkrtqekfalkmlqdcpkarre
velhwrasqcphivrivdvyenlyagrkcllivmecldggelfsriqdrgdqaftereas
eimksigeaiqylhsiniahrdvkpenllytskrpnailkltdfgfakettytpyyvape
vlgpekydkscdmwslgvimyillcgyppfysnhglaispgmktrirmgqyefpnpewse
vseevkmlirnllkteptqrmtitefmnhpwimqst