PDB entry 6t6n

View 6t6n on RCSB PDB site
Description: Crystal structure of Klebsiella pneumoniae FabG2(NADH-dependent) in complex with NADH at 2.5 A resolution
Class: biosynthetic protein
Keywords: Fatty acid biosynthesis, FabG, (3-oxoacyl-(Acyl-carrier-protein) reductase), NADH, NADPH, complex, FAS-II, BIOSYNTHETIC PROTEIN
Deposited on 2019-10-18, released 2020-11-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-06-02, with a file datestamp of 2021-05-28.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3-oxoacyl-[acyl-carrier protein] reductase
    Species: Klebsiella pneumoniae 30684/NJST258_2 [TaxId:1420013]
    Gene: KPNJ2_02761
    Database cross-references and differences (RAF-indexed):
    • Uniprot W8VGR4 (1-244)
      • engineered mutation (2)
    Domains in SCOPe 2.08: d6t6na_
  • Chain 'B':
    Compound: 3-oxoacyl-[acyl-carrier protein] reductase
    Species: Klebsiella pneumoniae 30684/NJST258_2 [TaxId:1420013]
    Gene: KPNJ2_02761
    Database cross-references and differences (RAF-indexed):
    • Uniprot W8VGR4 (1-244)
      • engineered mutation (2)
    Domains in SCOPe 2.08: d6t6nb_
  • Chain 'C':
    Compound: 3-oxoacyl-[acyl-carrier protein] reductase
    Species: Klebsiella pneumoniae 30684/NJST258_2 [TaxId:1420013]
    Gene: KPNJ2_02761
    Database cross-references and differences (RAF-indexed):
    • Uniprot W8VGR4 (1-244)
      • engineered mutation (2)
    Domains in SCOPe 2.08: d6t6nc_
  • Chain 'D':
    Compound: 3-oxoacyl-[acyl-carrier protein] reductase
    Species: Klebsiella pneumoniae 30684/NJST258_2 [TaxId:1420013]
    Gene: KPNJ2_02761
    Database cross-references and differences (RAF-indexed):
    • Uniprot W8VGR4 (1-244)
      • engineered mutation (2)
    Domains in SCOPe 2.08: d6t6nd_
  • Chain 'E':
    Compound: 3-oxoacyl-[acyl-carrier protein] reductase
    Species: Klebsiella pneumoniae 30684/NJST258_2 [TaxId:1420013]
    Gene: KPNJ2_02761
    Database cross-references and differences (RAF-indexed):
    • Uniprot W8VGR4 (1-244)
      • engineered mutation (2)
    Domains in SCOPe 2.08: d6t6ne_
  • Chain 'F':
    Compound: 3-oxoacyl-[acyl-carrier protein] reductase
    Species: Klebsiella pneumoniae 30684/NJST258_2 [TaxId:1420013]
    Gene: KPNJ2_02761
    Database cross-references and differences (RAF-indexed):
    • Uniprot W8VGR4 (1-244)
      • engineered mutation (2)
    Domains in SCOPe 2.08: d6t6nf_
  • Chain 'G':
    Compound: 3-oxoacyl-[acyl-carrier protein] reductase
    Species: Klebsiella pneumoniae 30684/NJST258_2 [TaxId:1420013]
    Gene: KPNJ2_02761
    Database cross-references and differences (RAF-indexed):
    • Uniprot W8VGR4 (1-244)
      • engineered mutation (2)
    Domains in SCOPe 2.08: d6t6ng_
  • Chain 'H':
    Compound: 3-oxoacyl-[acyl-carrier protein] reductase
    Species: Klebsiella pneumoniae 30684/NJST258_2 [TaxId:1420013]
    Gene: KPNJ2_02761
    Database cross-references and differences (RAF-indexed):
    • Uniprot W8VGR4 (1-244)
      • engineered mutation (2)
    Domains in SCOPe 2.08: d6t6nh_
  • Heterogens: NAI, GOL, MLT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6t6nA (A:)
smalasktaivtgaargigfgiaqvlaregarviiadrdahgeaaaaslresgaqalfis
cniaektqvealfsqaeeafgpvdilvnnaginrdamlhklteadwdtvidvnlkgtflc
mqqaairmrergagriiniasaswlgnvgqtnysaskagvvgmtktacrelakkgvtvna
icpgfidtdmtrgvpenvwqimiskipagyageakdvgecvaflasdgaryingevinvg
ggmvl

    Sequence, based on observed residues (ATOM records): (download) 
    >6t6nA (A:)
malasktaivtgaargigfgiaqvlaregarviiadrdahgeaaaaslresgaqalfisc
niaektqvealfsqaeeafgpvdilvnnaginrdamlhklteadwdtvidvnlkgtflcm
qqaairmrergagriiniasaswlgnvgqtnysaskagvvgmtktacrelakkgvtvnai
cpgfidtdmtrgvpenvwqimiskipagyageakdvgecvaflasdgaryingevinvgg
gmvl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6t6nB (B:)
smalasktaivtgaargigfgiaqvlaregarviiadrdahgeaaaaslresgaqalfis
cniaektqvealfsqaeeafgpvdilvnnaginrdamlhklteadwdtvidvnlkgtflc
mqqaairmrergagriiniasaswlgnvgqtnysaskagvvgmtktacrelakkgvtvna
icpgfidtdmtrgvpenvwqimiskipagyageakdvgecvaflasdgaryingevinvg
ggmvl

    Sequence, based on observed residues (ATOM records): (download) 
    >6t6nB (B:)
malasktaivtgaargigfgiaqvlaregarviiadrdahgeaaaaslresgaqalfisc
niaektqvealfsqaeeafgpvdilvnnaginrdamlhklteadwdtvidvnlkgtflcm
qqaairmrergagriiniasaswlgnvgqtnysaskagvvgmtktacrelakkgvtvnai
cpgfidtdmtrgvpenvwqimiskipagyageakdvgecvaflasdgaryingevinvgg
gmvl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6t6nC (C:)
smalasktaivtgaargigfgiaqvlaregarviiadrdahgeaaaaslresgaqalfis
cniaektqvealfsqaeeafgpvdilvnnaginrdamlhklteadwdtvidvnlkgtflc
mqqaairmrergagriiniasaswlgnvgqtnysaskagvvgmtktacrelakkgvtvna
icpgfidtdmtrgvpenvwqimiskipagyageakdvgecvaflasdgaryingevinvg
ggmvl

    Sequence, based on observed residues (ATOM records): (download) 
    >6t6nC (C:)
malasktaivtgaargigfgiaqvlaregarviiadrdahgeaaaaslresgaqalfisc
niaektqvealfsqaeeafgpvdilvnnaginrdamlhklteadwdtvidvnlkgtflcm
qqaairmrergagriiniasaswlgnvgqtnysaskagvvgmtktacrelakkgvtvnai
cpgfidtdmtrgvpenvwqimiskipagyageakdvgecvaflasdgaryingevinvgg
gmvl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6t6nD (D:)
smalasktaivtgaargigfgiaqvlaregarviiadrdahgeaaaaslresgaqalfis
cniaektqvealfsqaeeafgpvdilvnnaginrdamlhklteadwdtvidvnlkgtflc
mqqaairmrergagriiniasaswlgnvgqtnysaskagvvgmtktacrelakkgvtvna
icpgfidtdmtrgvpenvwqimiskipagyageakdvgecvaflasdgaryingevinvg
ggmvl

    Sequence, based on observed residues (ATOM records): (download) 
    >6t6nD (D:)
malasktaivtgaargigfgiaqvlaregarviiadrdahgeaaaaslresgaqalfisc
niaektqvealfsqaeeafgpvdilvnnaginrdamlhklteadwdtvidvnlkgtflcm
qqaairmrergagriiniasaswlgnvgqtnysaskagvvgmtktacrelakkgvtvnai
cpgfidtdmtrgvpenvwqimiskipagyageakdvgecvaflasdgaryingevinvgg
gmvl

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6t6nE (E:)
smalasktaivtgaargigfgiaqvlaregarviiadrdahgeaaaaslresgaqalfis
cniaektqvealfsqaeeafgpvdilvnnaginrdamlhklteadwdtvidvnlkgtflc
mqqaairmrergagriiniasaswlgnvgqtnysaskagvvgmtktacrelakkgvtvna
icpgfidtdmtrgvpenvwqimiskipagyageakdvgecvaflasdgaryingevinvg
ggmvl

    Sequence, based on observed residues (ATOM records): (download) 
    >6t6nE (E:)
malasktaivtgaargigfgiaqvlaregarviiadrdahgeaaaaslresgaqalfisc
niaektqvealfsqaeeafgpvdilvnnaginrdamlhklteadwdtvidvnlkgtflcm
qqaairmrergagriiniasaswlgnvgqtnysaskagvvgmtktacrelakkgvtvnai
cpgfidtdmtrgvpenvwqimiskipagyageakdvgecvaflasdgaryingevinvgg
gmvl

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6t6nF (F:)
smalasktaivtgaargigfgiaqvlaregarviiadrdahgeaaaaslresgaqalfis
cniaektqvealfsqaeeafgpvdilvnnaginrdamlhklteadwdtvidvnlkgtflc
mqqaairmrergagriiniasaswlgnvgqtnysaskagvvgmtktacrelakkgvtvna
icpgfidtdmtrgvpenvwqimiskipagyageakdvgecvaflasdgaryingevinvg
ggmvl

    Sequence, based on observed residues (ATOM records): (download) 
    >6t6nF (F:)
malasktaivtgaargigfgiaqvlaregarviiadrdahgeaaaaslresgaqalfisc
niaektqvealfsqaeeafgpvdilvnnaginrdamlhklteadwdtvidvnlkgtflcm
qqaairmrergagriiniasaswlgnvgqtnysaskagvvgmtktacrelakkgvtvnai
cpgfidtdmtrgvpenvwqimiskipagyageakdvgecvaflasdgaryingevinvgg
gmvl

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >6t6nG (G:)
smalasktaivtgaargigfgiaqvlaregarviiadrdahgeaaaaslresgaqalfis
cniaektqvealfsqaeeafgpvdilvnnaginrdamlhklteadwdtvidvnlkgtflc
mqqaairmrergagriiniasaswlgnvgqtnysaskagvvgmtktacrelakkgvtvna
icpgfidtdmtrgvpenvwqimiskipagyageakdvgecvaflasdgaryingevinvg
ggmvl

    Sequence, based on observed residues (ATOM records): (download) 
    >6t6nG (G:)
malasktaivtgaargigfgiaqvlaregarviiadrdahgeaaaaslresgaqalfisc
niaektqvealfsqaeeafgpvdilvnnaginrdamlhklteadwdtvidvnlkgtflcm
qqaairmrergagriiniasaswlgnvgqtnysaskagvvgmtktacrelakkgvtvnai
cpgfidtdmtrgvpenvwqimiskipagyageakdvgecvaflasdgaryingevinvgg
gmvl

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6t6nH (H:)
smalasktaivtgaargigfgiaqvlaregarviiadrdahgeaaaaslresgaqalfis
cniaektqvealfsqaeeafgpvdilvnnaginrdamlhklteadwdtvidvnlkgtflc
mqqaairmrergagriiniasaswlgnvgqtnysaskagvvgmtktacrelakkgvtvna
icpgfidtdmtrgvpenvwqimiskipagyageakdvgecvaflasdgaryingevinvg
ggmvl

    Sequence, based on observed residues (ATOM records): (download) 
    >6t6nH (H:)
malasktaivtgaargigfgiaqvlaregarviiadrdahgeaaaaslresgaqalfisc
niaektqvealfsqaeeafgpvdilvnnaginrdamlhklteadwdtvidvnlkgtflcm
qqaairmrergagriiniasaswlgnvgqtnysaskagvvgmtktacrelakkgvtvnai
cpgfidtdmtrgvpenvwqimiskipagyageakdvgecvaflasdgaryingevinvgg
gmvl