PDB entry 6t5m

View 6t5m on RCSB PDB site
Description: Crystal structure of 2-methylisocitrate lyase (PrpB) from Pseudomonas aeruginosa in complex with Mg(II)-pyruvate.
Class: lyase
Keywords: 2-methlyisocitrate lyase, PrpB, Propionate metabolism, Lyase
Deposited on 2019-10-16, released 2020-09-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-09-30, with a file datestamp of 2020-09-25.
Experiment type: XRAY
Resolution: 1.76 Å
R-factor: N/A
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 2-methylisocitrate lyase
    Species: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) [TaxId:208964]
    Gene: prpB, PA0796
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6t5ma_
  • Chain 'B':
    Compound: 2-methylisocitrate lyase
    Species: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) [TaxId:208964]
    Gene: prpB, PA0796
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6t5mb_
  • Chain 'C':
    Compound: 2-methylisocitrate lyase
    Species: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) [TaxId:208964]
    Gene: prpB, PA0796
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6t5mc_
  • Chain 'D':
    Compound: 2-methylisocitrate lyase
    Species: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) [TaxId:208964]
    Gene: prpB, PA0796
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6t5md_
  • Heterogens: PYR, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6t5mA (A:)
msqtsltpgqrfreavatehplqvvgtinanhallakragfkaiylsgggvaagslglpd
lgisglddvltdvrritdvcdlpllvdvdtgfgssafnvartvksmikfgaaamhiedqv
gakrcghrpnkeivsqqemvdrikaavdarsddsfvimartdalaveglqaaidracacv
eagadmifpeamtelamykefaaavkvpvlanitefgatplfttdelasadvslvlypls
aframnkaaenvytairrdgtqknvidtmqtrmelydridyhsfeqkldalfaqkkna

    Sequence, based on observed residues (ATOM records): (download) 
    >6t5mA (A:)
ltpgqrfreavatehplqvvgtinanhallakragfkaiylsgggvaagslglpdlgisg
lddvltdvrritdvcdlpllvdvdtgfgssafnvartvksmikfgaaamhiedqveivsq
qemvdrikaavdarsddsfvimartdalaveglqaaidracacveagadmifpeamtela
mykefaaavkvpvlanitefgatplfttdelasadvslvlyplsaframnkaaenvytai
rrdgtqknvidtmqtrmelydridyhsfeqkldalf

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6t5mB (B:)
msqtsltpgqrfreavatehplqvvgtinanhallakragfkaiylsgggvaagslglpd
lgisglddvltdvrritdvcdlpllvdvdtgfgssafnvartvksmikfgaaamhiedqv
gakrcghrpnkeivsqqemvdrikaavdarsddsfvimartdalaveglqaaidracacv
eagadmifpeamtelamykefaaavkvpvlanitefgatplfttdelasadvslvlypls
aframnkaaenvytairrdgtqknvidtmqtrmelydridyhsfeqkldalfaqkkna

    Sequence, based on observed residues (ATOM records): (download) 
    >6t5mB (B:)
ltpgqrfreavatehplqvvgtinanhallakragfkaiylsgggvaagslglpdlgisg
lddvltdvrritdvcdlpllvdvdtgfgssafnvartvksmikfgaaamhiedqveivsq
qemvdrikaavdarsddsfvimartdalaveglqaaidracacveagadmifpeamtela
mykefaaavkvpvlanitefgatplfttdelasadvslvlyplsaframnkaaenvytai
rrdgtqknvidtmqtrmelydridyhsfeqkldalf

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6t5mC (C:)
msqtsltpgqrfreavatehplqvvgtinanhallakragfkaiylsgggvaagslglpd
lgisglddvltdvrritdvcdlpllvdvdtgfgssafnvartvksmikfgaaamhiedqv
gakrcghrpnkeivsqqemvdrikaavdarsddsfvimartdalaveglqaaidracacv
eagadmifpeamtelamykefaaavkvpvlanitefgatplfttdelasadvslvlypls
aframnkaaenvytairrdgtqknvidtmqtrmelydridyhsfeqkldalfaqkkna

    Sequence, based on observed residues (ATOM records): (download) 
    >6t5mC (C:)
sltpgqrfreavatehplqvvgtinanhallakragfkaiylsgggvaagslglpdlgis
glddvltdvrritdvcdlpllvdvdtgfgssafnvartvksmikfgaaamhiedqveivs
qqemvdrikaavdarsddsfvimartdalaveglqaaidracacveagadmifpeamtel
amykefaaavkvpvlanitefgatplfttdelasadvslvlyplsaframnkaaenvyta
irrdgtqknvidtmqtrmelydridyhsfeqkldalf

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6t5mD (D:)
msqtsltpgqrfreavatehplqvvgtinanhallakragfkaiylsgggvaagslglpd
lgisglddvltdvrritdvcdlpllvdvdtgfgssafnvartvksmikfgaaamhiedqv
gakrcghrpnkeivsqqemvdrikaavdarsddsfvimartdalaveglqaaidracacv
eagadmifpeamtelamykefaaavkvpvlanitefgatplfttdelasadvslvlypls
aframnkaaenvytairrdgtqknvidtmqtrmelydridyhsfeqkldalfaqkkna

    Sequence, based on observed residues (ATOM records): (download) 
    >6t5mD (D:)
ltpgqrfreavatehplqvvgtinanhallakragfkaiylsgggvaagslglpdlgisg
lddvltdvrritdvcdlpllvdvdtgfgssafnvartvksmikfgaaamhiedqveivsq
qemvdrikaavdarsddsfvimartdalaveglqaaidracacveagadmifpeamtela
mykefaaavkvpvlanitefgatplfttdelasadvslvlyplsaframnkaaenvytai
rrdgtqknvidtmqtrmelydridyhsfeqkldalf