PDB entry 6t5j

View 6t5j on RCSB PDB site
Description: structure of nudt15 in complex with inhibitor th1760
Deposited on 2019-10-16, released 2020-07-29
The last revision was dated 2020-09-30, with a file datestamp of 2020-09-25.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: N/A
AEROSPACI score: 0.53 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Probable 8-oxo-dGTP diphosphatase NUDT15
    Species: Homo sapiens [TaxId:9606]
    Gene: NUDT15, MTH2
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Probable 8-oxo-dGTP diphosphatase NUDT15
    Species: Homo sapiens [TaxId:9606]
    Gene: NUDT15, MTH2
    Database cross-references and differences (RAF-indexed):
  • Heterogens: MKB, MG, CL, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6t5jA (A:)
mtasaqprgrrpgvgvgvvvtsckhprcvllgkrkgsvgagsfqlpgghlefgetweeca
qretweeaalhlknvhfasvvnsfiekenyhyvtilmkgevdvthdsepknvepeknesw
ewvpweelppldqlfwglrclkeqgydpfkedlnhlvgykgnhl

    Sequence, based on observed residues (ATOM records):
    >6t5jA (A:)
rrpgvgvgvvvtsckhprcvllgkrkgsvgagsfqlpgghlefgetweecaqretweeaa
lhlknvhfasvvnsfiekenyhyvtilmkgevdvthdsepknvepekneswewvpweelp
pldqlfwglrclkeqgydpfkedlnhlvgykgnh

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6t5jB (B:)
mtasaqprgrrpgvgvgvvvtsckhprcvllgkrkgsvgagsfqlpgghlefgetweeca
qretweeaalhlknvhfasvvnsfiekenyhyvtilmkgevdvthdsepknvepeknesw
ewvpweelppldqlfwglrclkeqgydpfkedlnhlvgykgnhl

    Sequence, based on observed residues (ATOM records):
    >6t5jB (B:)
rrpgvgvgvvvtsckhprcvllgkrkgsvgagsfqlpgghlefgetweecaqretweeaa
lhlknvhfasvvnsfiekenyhyvtilmkgevdvthdsepknvepekneswewvpweelp
pldqlfwglrclkeqgydpfkedlnhlvgykgnh