PDB entry 6t4u

View 6t4u on RCSB PDB site
Description: ROR(gamma)t ligand binding domain in complex with 20-alpha-hydroxycholesterol and allosteric ligand MRL871
Class: gene regulation
Keywords: Nuclear Receptor, Allosteric, Inverse Agonist, Inhibitor, GENE REGULATION
Deposited on 2019-10-15, released 2020-11-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-02-17, with a file datestamp of 2021-02-12.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Nuclear receptor ROR-gamma
  Species: Homo sapiens [TaxId:9606]
  Gene: RORC, NR1F3, RORG, RZRG
  Database cross-references and differences (RAF-indexed):
  • Uniprot P51449 (0-239)
    • conflict (187)
  Domains in SCOPe 2.08: d6t4ua_
• Heterogens: HCD, 4F1, GOL, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >6t4uA (A:)
  teiehlvqsvcksyretcqlrledllrqrsnifsreevtgyqrksmwemwercahhltea
  iqyvvefakrlsgfmelcqndqivllkagamevvlvrmcraynadnrtvffegkyggmel
  fralgcselissifdfshslsalhfsedeialytalvlinahrpglqekrkveqlqynle
  lafhhhlhkthrqsilaklppkgklrslcsqhverlqifqhlhpivvqaafpplykelfs