PDB entry 6t4g

View 6t4g on RCSB PDB site
Description: ROR(gamma)t ligand binding domain in complex with cholesterol and allosteric ligand FM26
Class: gene regulation
Keywords: Nuclear Receptor, Allosteric, Inverse Agonist, Inhibitor, GENE REGULATION
Deposited on 2019-10-14, released 2020-11-25
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-11-25, with a file datestamp of 2020-11-20.
Experiment type: XRAY
Resolution: 1.93 Å
R-factor: N/A
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Nuclear receptor ROR-gamma
    Species: Homo sapiens [TaxId:9606]
    Gene: RORC, NR1F3, RORG, RZRG
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51449 (Start-262)
      • conflict (210)
    Domains in SCOPe 2.07: d6t4ga_
  • Heterogens: CLR, L3E, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6t4gA (A:)
gsshhhhhhssglvprgshmaslteiehlvqsvcksyretcqlrledllrqrsnifsree
vtgyqrksmwemwercahhlteaiqyvvefakrlsgfmelcqndqivllkagamevvlvr
mcraynadnrtvffegkyggmelfralgcselissifdfshslsalhfsedeialytalv
linahrpglqekrkveqlqynlelafhhhlhkthrqsilaklppkgklrslcsqhverlq
ifqhlhpivvqaafpplykelfs

    Sequence, based on observed residues (ATOM records): (download) 
    >6t4gA (A:)
lteiehlvqsvcksyretcqlrledllrqrsnifsreevtgyqrksmwemwercahhlte
aiqyvvefakrlsgfmelcqndqivllkagamevvlvrmcraynadnrtvffegkyggme
lfralgcselissifdfshslsalhfsedeialytalvlinahrpglqekrkveqlqynl
elafhhhlhkthrqsilaklppkgklrslcsqhverlqifqhlhpivvqaafpplykelf
s