PDB entry 6t41

View 6t41 on RCSB PDB site
Description: cdk8/cyclin c in complex with n-(4-chlorobenzyl)isoquinolin-4-amine
Deposited on 2019-10-11, released 2020-01-01
The last revision was dated 2020-02-19, with a file datestamp of 2020-02-14.
Experiment type: XRAY
Resolution: 2.45 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cyclin-dependent kinase 8
    Species: Homo sapiens [TaxId:9606]
    Gene: CDK8
    Database cross-references and differences (RAF-indexed):
    • Uniprot P49336 (3-End)
      • expression tag (0-2)
  • Chain 'B':
    Compound: Cyclin-C
    Species: Homo sapiens [TaxId:9606]
    Gene: CCNC
    Database cross-references and differences (RAF-indexed):
    • Uniprot P24863 (3-End)
      • expression tag (0-2)
  • Heterogens: MFE, EDO, FMT, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6t41A (A:)
ddkmdydfkvklsserervedlfeyegckvgrgtyghvykakrkdgkddkdyalkqiegt
gismsacreiallrelkhpnvislqkvflshadrkvwllfdyaehdlwhiikfhraskan
kkpvqlprgmvksllyqildgihylhanwvlhrdlkpanilvmgegpergrvkiadmgfa
rlfnsplkpladldpvvvtfwyrapelllgarhytkaidiwaigcifaelltsepifhcr
qediktsnpyhhdqldrifnvmgfpadkdwedikkmpehstlmkdfrrntytncslikym
ekhkvkpdskafhllqklltmdpikritseqamqdpyfledplptsdvfagcqipypkre
flteeepddkgdkknqqqqqgnnhtngtghpgnqdsshtqgpplkkv

    Sequence, based on observed residues (ATOM records):
    >6t41A (A:)
ddkmdydfkvklsserervedlfeyegckvgrgtyghvykakrkdgkddkdyalkqiegt
gismsacreiallrelkhpnvislqkvflshadrkvwllfdyaehdlwhiikfhraskan
pvqlprgmvksllyqildgihylhanwvlhrdlkpanilvmgegpergrvkiadmgfarl
fnsplkptfwyrapelllgarhytkaidiwaigcifaelltsepifhcrqenpyhhdqld
rifnvmgfpadkdwedikkmpehstlmkdfrrntytncslikymekhkvkpdskafhllq
klltmdpikritseqamqdpyfledplptsdvfagcqipypkrefl

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6t41B (B:)
dkamagnfwqsshylqwildkqdllkerqkdlkflseeeywklqifftnviqalgehlkl
rqqviatatvyfkrfyaryslksidpvlmaptcvflaskveefgvvsntrliaaatsvlk
trfsyafpkefpyrmnhilecefyllelmdcclivyhpyrpllqyvqdmgqedmllplaw
rivndtyrtdlcllyppfmialaclhvacvvqqkdarqwfaelsvdmekileiirvilkl
yeqwknfderkematilskmpkpkpppnsegeqgpngsqnssysqs

    Sequence, based on observed residues (ATOM records):
    >6t41B (B:)
dkamagnfwqsshylqwildkqdllkerqkdlkflseeeywklqifftnviqalgehlkl
rqqviatatvyfkrfyaryslksidpvlmaptcvflaskveefgvvsntrliaaatsvlk
trfsyafpkefpyrmnhilecefyllelmdcclivyhpyrpllqyvqdmgqedmllplaw
rivndtyrtdlcllyppfmialaclhvacvvqqkdarqwfaelsvdmekileiirvilkl
yeqwknfderkematilskmpkpkppp