PDB entry 6t2k

View 6t2k on RCSB PDB site
Description: Furano[2,3-d]prymidine amides as Notum inhibitors
Class: hydrolase
Keywords: substrate, Hydrolase
Deposited on 2019-10-08, released 2020-01-01
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-06-29.
Experiment type: XRAY
Resolution: 1.38 Å
R-factor: N/A
AEROSPACI score: 0.62 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Palmitoleoyl-protein carboxylesterase NOTUM
    Species: Homo sapiens [TaxId:9606]
    Gene: NOTUM, OK/SW-CL.30
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6P988 (Start-373)
      • engineered mutation (252)
    Domains in SCOPe 2.08: d6t2ka_
  • Heterogens: M9K, SO4, NAG, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6t2kA (A:)
etgsaqqlnedlrlhlllntsvtcndgspagyylkesrgsrrwllfleggwycfnrencd
srydtmrrlmssrdwprtrtgtgilssqpeenpywwnanmvfipycssdvwsgassksek
neyafmgaliiqevvrellgrglsgakvlllagssaggtgvllnvdrvaeqleklgypai
qvrgladsgwfldnkqyrhtdcvdtitcapteairrgirywngvvpercrrqfqegeewn
cffgykvyptlrspvfvvqwlfdeaqltvdnvhltgqpvqeglrlyiqnlgrelrhtlkd
vpasfapaclsheiiirshwtdvqvkgtslpralhcwdrslhdshkasktplkgcpvhlv
dscpwphcnpscptgtkhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6t2kA (A:)
dlrlhlllntsvtcndgspagyylkesrgsrrwllfleggwycfnrencdsrydtmrrlm
ssrdwprtrtgtgilssqpeenpywwnanmvfipycssdvwsgassksekneyafmgali
iqevvrellgrglsgakvlllagssaggtgvllnvdrvaeqleklgypaiqvrgladsgw
fldnkqyrhapteairrgirywngvvpercrrqfqegeewncffgykvyptlrspvfvvq
wlfdeaqltvdnvhvqeglrlyiqnlgrelrhtlkdvpasfapaclsheiiirshwtdvq
vkgtslpralhcwdrslhtplkgcpvhlvdscpwphcnpscpt